Using Machine Learning to Distinguish Brain Tumor Progression From Pseudoprogression on Routine MRI

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. For over a century, malignant brain tumors such as glioblastoma (GBM) have carried a dismal prognosis. The most recent substantial advance has been provided by surgical resection and chemoradiation followed by adjuvant temozolomide therapy. Yet a problem during the requisite post-treatment surveillance imaging is that the brain's reaction to heavy doses of radiation can mimic the appearance of true tumor progression on MRI (Figure 1).