Daily Digest

Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. Researches performed a genome-wide association study of NAFL, cirrhosis and hepatocellular carcinoma, and integrated the findings with expression and proteomic data. The present study provides insights into the development of noninvasive evaluation of NAFL and new therapeutic options. Interactions between proteins help us understand how genes are functionally related and how they contribute to phenotypes. Experiments provide imperfect "ground truth" information about a small subset of potential interactions in a specific biological context, which can then be extended to the whole genome across different contexts, such as conditions, tissues, or species, through machine learning methods.