Machine learning microscope adapts lighting to improve diagnosis

Engineers at Duke University have developed a microscope that adapts its lighting angles, colors and patterns while teaching itself the optimal settings needed to complete a given diagnostic task. In the initial proof-of-concept study, the microscope simultaneously developed a lighting pattern and classification system that allowed it to quickly identify red blood cells infected by the malaria parasite more accurately than trained physicians and other machine learning approaches. The results appear online on November 19 in the journal Biomedical Optics Express. "A standard microscope illuminates a sample with the same amount of light coming from all directions, and that lighting has been optimized for human eyes over hundreds of years," said Roarke Horstmeyer, assistant professor of biomedical engineering at Duke. "But computers can see things humans can't," Hortmeyer said. "So not only have we redesigned the hardware to provide a diverse range of lighting options, we've allowed the microscope to optimize the illumination for itself."