Daily Digest

The human brain forms functional networks of correlated activity, which have been linked with both cognitive and clinical outcomes. However, the genetic variants affecting brain function are largely unknown. Here, researchers used resting-state functional magnetic resonance images from 47,276 individuals to discover and validate common genetic variants influencing intrinsic brain activity. They identified 45 new genetic regions associated with brain functional signatures (P 2.8 10 11). Although technological advances improved the identification of structural variants (SVs) in the human genome, their interpretation remains challenging.