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The Sixth International Conference on Case-Based Reasoning (ICCBR-05) took place from 23 August through 26 August 2005 at the downtown campus of De-Paul University, in the heart of Chicago's downtown Loop. The conference program included Industry Day, four workshops, and two days of technical paper presentations divided into poster sessions and a single plenary track. This report describes the conference in detail. Days 3 and 4 comprised presentations and posters on theoretical and applied CBR research, as well as invited talks from two distinguished scholars: Derek Bridge, the University College Cork, and Craig Knoblock, the University of Southern California. ICCBR-05 received 74 paper submissions from 19 countries around the world.