Modeling muscle

Adaptive behaviors ranging from self-assembly to self-healing showcase the ability of such systems to sense and adapt to dynamic environments based on signaling between living cells. This signaling takes on many forms--biochemical, mechanical, and electrical--and uncovering it has become as much the purview of regenerative medicine as of fundamental biology. We cannot reverse-engineer native tissues if we do not understand the fundamental design rules and principles that govern their assembly from the bottom up (1). Movement is fundamental to many living systems and driven primarily by skeletal muscle in human bodies. Disease or damage that limits the functionality of skeletal muscle severely affects human health, mobility, and quality of life.