The Problem With Early Cancer Detection

The discovery began, as many breakthroughs do, with an observation that didn't quite make sense. In 1948, two French researchers, Paul Mandel and Pierre Métais, published a little-noticed paper in a scientific journal. Working in a laboratory in Strasbourg, they had been cataloguing the chemical contents of blood plasma--that river of life teeming with proteins, sugars, waste, nutrients, and cellular debris. Amid this familiar inventory, they'd spotted an unexpected presence: fragments of DNA drifting freely. The finding defied biological orthodoxy. DNA was thought to remain locked inside the nuclei of cells, and not float around on its own.