A Computational Model of Reasoning from the Clinical Literature

This article explores the premise that a formalized representation of empirical studies can play a central role in computer-based decision support. The specific motivations underlying this research include the following propositions: (1) Reasoning from experimental evidence contained in the clinical literature is central to the decisions physicians make in patient care. Furthermore, the model can help us better understand the general principles of reasoning from experimental evidence both in medicine and other domains. Roundsman is a developmental computer system that draws on structured representations of the clinical literature to critique plans for the management of primary breast cancer. Roundsman is able to produce patient-specific analyses of breast cancer-management options based on the 24 clinical studies currently encoded in its knowledge base.