SM

We detail here the different observables used to quantify the quality of the generated samples. Some recent works have dedicated large efforts to understand this object [2], from which we can extract a generic method to compute a reasonable estimate. First, let us recall that AIS is based on a simulated annealing process where a configuration is gradually brought from temperature T = to T = 1 using a set of bridging distributions. In our case it is done using MC sampling layer-wise. In practice, we took the 50 more active sites.