we believe that our Genetic Expert-Guided Learning (GEGL) framework provides a substantial contribution to the field our responses to the comments. Response to R1

We sincerely thank all reviewers for their valuable efforts and insightful comments. We thank R1 for the helpful comment. Following R1's insightful suggestion, we compared GEGL with an additional "ablation" We thank R1 for the opportunity to make the following clarifications. We thank R2 and R3 for mentioning an important point. R2's comment: the current literature fails to search for a molecule that is high-scoring and realistic simultaneously.