Supplementary Material Noise2Score: Tweedie's Approach to Self-Supervised Image Denoising without Clean Images Kwanyoung Kim 1 Jong Chul Ye1,2,3 1 Department of Bio and Brain Engineering 2

In case of the BSD68 dataset, we transform the CBSD68 datset into gray-scale images. In the training phase, we only selected one noise distribution. In the case of the "known" FISH categories, which consisted of 1000 images. Accordingly, we used a two-step approach in which the Gaussian noise is first removed using the Tweedie's formula for the Gaussian case and the Poisson noise is subsequentially reduced using the Tweedie's formula for the Poisson noise. Table 2: Comparison results in FMD data set with real noises in terms of PSNR (dB).