A Fast Multi-Resolution Method for Detection of Significant Spatial Disease Clusters

Given an N N grid of squares, where each square has a count and an underlying population, our goal is to find the square region with the highest density, and to calculate its significance by randomization. Any density measure D, dependent on the total count and total population of a region, can be used. For example, if each count represents the number of disease cases occurring in that square, we can use Kulldorff's spatial scan statistic D