Predicting Action Content On-Line and in Real Time before Action Onset – an Intracranial Human Study

The ability to predict action content from neural signals in real time before the action occurs has been long sought in the neuroscientific study of decision-making, agency and volition. Online real-time (ORT) prediction is important for understanding the relation between neural correlates of decision-making and conscious, voluntary action as well as for brain-machine interfaces. Here, epilepsy patients, implanted with intracranial depth microelectrodes or subdural grid electrodes for clinical purposes, participated in a "matching-pennies" game against an opponent. In each trial, subjects were given a 5 s countdown, after which they had to raise their left or right hand immediately as the "go" signal appeared on a computer screen. They won a fixed amount of money if they raised a different hand than their opponent and lost that amount otherwise.