T-SYNTH: A Knowledge-Based Dataset of Synthetic Breast Images

Responsible for approximately two million new cases and over six hundred thousand deaths in 2022 alone (Sung et al., 2021), breast cancer remains a prominent global health concern, and is expected to account nearly one-third of all newly diagnosed cancers among women in the United States (DeSantis et al., 2016). According to the most recent report from International Agency for Research on Cancer (Bray et al., 2024), it is one of the most widespread cancers diagnosed worldwide, both in the number of cases and associated deaths. Consequently, medical imaging techniques are indispensable for screening, diagnosis, and further research into the disease. Historically, the most common imaging technique for breast cancer screening is digital mammography (DM), in which a 2D x-ray projection of a compressed breast is taken. Digital breast tomosynthesis (DBT), a pseudo-3D imaging technique, has been increasingly adopted, demonstrating improved screening performance (Asbeutah et al., 2019; Sprague et al., 2023).