Fed-BioMed: Open, Transparent and Trusted Federated Learning for Real-world Healthcare Applications

The need for large amounts of data to develop Artificial Intelligence (AI) in healthcare has motivated a number of national and international initiatives aimed at creating medical data lakes accessible to researchers, such as the French Health Data Hub [10], the UK BioBank [59], the US ADNI [26] and TCGA [60], among the many [58, 40, 7]. In spite of these initiatives, there are still major bottlenecks preventing the widespread availability of large centralized repositories of healthcare information [63]. To overcome these limitations, Federated Learning (FL) has been proposed as a working paradigm to enable the training of ML models on large datasets from diverse sources while guaranteeing the respect of data privacy and governance. The basic paradigm of FL consists of iterating the following steps: i) model training is performed locally in the hospitals starting from a common initialization, ii) the resulting model parameters are subsequently shared (instead of the data) and aggregated, to define a global model iii) transmitted back to the hospitals to initiate a new local training step. Under certain conditions [39], this procedure is guaranteed to converge to a final global model representing an optimal consensus among the hospitals participating in the experiment. FL is particularly suited for applications in sensitive domains, such as healthcare and biomedical research [48, 9, 13].