Knowledge-Based Simulation of Genetic Regulation in Bacteriophage Lambda. Scott Meyers, Peter Friedland, Aug 1983 card 1 of 1

Simuldtois serve two major purposes: the first is the verification of scientific thP.ories the second is xperimental result prcliction. Thr? verification function is called upon when existing t:leories are btling cxtended or new theories are being ç enerated to explain experimental data: the predictive capabilities are used to predict laboratory results in order to eliminate a great deal of experimmtal effort. An esoecially important role for a simulation pro.warn would be as par; of a larger employing art ficial innelligence techniques to develop mcd.els of a biological system bar:ed on experimental OUSerwitiOris. Such a program would accept as Input observations of a s; stem cud would!fiocii:ce as output a model for tn.t system that could account for the observations. The r.:niu!ation portion of such a program would be a crucial tool for ensuring that on:y theories mat were con::..-4 with thc data were dewloocci. It's a major research goal Cf the HOLDEN pi met to explore methods tor building a systym