The prediction of protein structure from amino acid sequence has become the Holy Grail of computational molecular biology. Since Anfinsen [1973] first noted that the information necessary for protein folding resides completely within the primary structure, molecular biologists have been fascinated with the possibility of obtaining a complete three-dimensional picture of a protein by simply applying the proper algorithm to a known amino acid sequence. The development of rapid methods of DNA sequencing coupled with the straightforward translation of the genetic code into protein sequences has amplified the urgent need for automated methods of interpreting these one-dimensional, linear sequences in terms of three-dimensional structure and function. Although improvements in computational capabilities, the development of area detectors, and the widespread use of synchrotron radiation have reduced the amount of time necessary to determine a protein structure by X-ray crystallography, a crystal structure determination may still require one or more man-years.

He also taught the biochemistry course that I finally took, two years after finishing my Ph.D. David J. States deserves much of the credit as well. In the three years we have been working together, he greatly extended my understanding of not only what biologists know, but how they think. He has read several drafts of this chapter and made helpful suggestions. David Landsman, Mark Boguski, Kalí Tal and Jill Shirmer have also read the chapter and made suggestions. Angel Lee graciously supplied the gel used in Figure 4. Of course, all remaining mistakes are my responsibility.

The editors have provided him with special introductory sections as a ing guide to a thorough understand of the reports.

Current research has succeeded in despite much work attempting to do so, human-- exploring a large number of domains and has explored machine communication is not yet sensitive to dialogue some nontraditional pedagogical strategies, such as partnering, context and to what is known or knowable about the student's mentoring, and scaffolding.

By studying biological systems, Several definitions for the term robot have been proposed principles may be discovered that can be used, perhaps by (Jablonowski and Posey, 1985). None of these definitions analogy, to improve the functional components of a robot are adequate because they exclude robot intelligence of as well as their cooperation.

Our descriptive vocabulary may still In this article I propose to describe an area of artificial contain proper names as modifiers but the explanatory intelligence (Al) research that I and several colleagues vocabulary now involves the impersonal qualities of an have been enaged in for a number of years.

To test the program during its development, MyeTs and his students would select especially difficult cases for considemtion, often ones drawn fTOm published clinical pathological confeTences in medical journals. AfteT seveTal years of testing and rf:finement of the knowledge base, the study outlined in the following chapteT was peTformed. To document the strengths and weaknesses of the pTogmm, the gTOUP performed a systematic evaluation of the pTOgTam's capabilities.

D E PA R T M E N T O F E L E CT R IC A L ENGINEERING UNIVE RSITY O F ILLIN O IS C H A M P A IG N, IL L.

A plethora of words are used to describe the spectrum of human emotions, but how many emotions are there really, and how do they interact? Over the past few decades, several theories of emotion have been proposed, each based around the existence of a set of 'basic emotions', and each supported by an extensive variety of research including studies in facial expression, ethology, neurology and physiology. Here we present research based on a theory that people transmit their understanding of emotions through the language they use surrounding emotion keywords. Using a labelled corpus of over 21,000 tweets, six of the basic emotion sets proposed in existing literature were analysed using Latent Semantic Clustering (LSC), evaluating the distinctiveness of the semantic meaning attached to the emotional label. We hypothesise that the more distinct the language is used to express a certain emotion, then the more distinct the perception (including proprioception) of that emotion is, and thus more 'basic'. This allows us to select the dimensions best representing the entire spectrum of emotion. We find that Ekman's set, arguably the most frequently used for classifying emotions, is in fact the most semantically distinct overall. Next, taking all analysed (that is, previously proposed) emotion terms into account, we determine the optimal semantically irreducible basic emotion set using an iterative LSC algorithm. Our newly-derived set (Accepting, Ashamed, Contempt, Interested, Joyful, Pleased, Sleepy, Stressed) generates a 6.1% increase in distinctiveness over Ekman's set (Angry, Disgusted, Joyful, Sad, Scared). We also demonstrate how using LSC data can help visualise emotions. We introduce the concept of an Emotion Profile and briefly analyse compound emotions both visually and mathematically.

A vast amount of textual web streams is influenced by events or phenomena emerging in the real world. The social web forms an excellent modern paradigm, where unstructured user generated content is published on a regular basis and in most occasions is freely distributed. The present Ph.D. Thesis deals with the problem of inferring information - or patterns in general - about events emerging in real life based on the contents of this textual stream. We show that it is possible to extract valuable information about social phenomena, such as an epidemic or even rainfall rates, by automatic analysis of the content published in Social Media, and in particular Twitter, using Statistical Machine Learning methods. An important intermediate task regards the formation and identification of features which characterise a target event; we select and use those textual features in several linear, non-linear and hybrid inference approaches achieving a significantly good performance in terms of the applied loss function. By examining further this rich data set, we also propose methods for extracting various types of mood signals revealing how affective norms - at least within the social web's population - evolve during the day and how significant events emerging in the real world are influencing them. Lastly, we present some preliminary findings showing several spatiotemporal characteristics of this textual information as well as the potential of using it to tackle tasks such as the prediction of voting intentions.