Motivated by the findings of modular structure in the association cortex, we study a multi-modular model of associative memory that can successfully store memory patterns with different levels of activity. We show that the segregation of synaptic conductances into intra-modular linear and inter-modular nonlinear ones considerably enhances the network's memory retrieval performance. Compared with the conventional, single-module associative memory network, the multi-modular network has two main advantages: It is less susceptible to damage to columnar input, and its response is consistent with the cognitive data pertaining to category specific impairment. 1 Introduction Cortical modules were observed in the somatosensory and visual cortices a few decades ago. These modules differ in their structure and functioning but are likely to be an elementary unit of processing in the mammalian cortex. Within each module the neurons are interconnected.

Motivated by the findings of modular structure in the association cortex, we study a multi-modular model of associative memory that can successfully store memory patterns with different levels of activity. Weshow that the segregation of synaptic conductances into intra-modular linear and inter-modular nonlinear ones considerably enhances the network's memory retrieval performance. Compared with the conventional, single-module associative memory network, the multi-modular network has two main advantages: It is less susceptible todamage to columnar input, and its response is consistent with the cognitive data pertaining to category specific impairment. 1 Introduction Cortical modules were observed in the somatosensory and visual cortices a few decades ago. These modules differ in their structure and functioning but are likely to be an elementary unit of processing in the mammalian cortex. Within each module the neurons are interconnected.

Similarity based fault tolerant retrieval in neural associative memories (NAM) has not lead to wiedespread applications. A drawback of the efficient Willshaw model for sparse patterns [Ste61, WBLH69], is that the high asymptotic information capacity is of little practical use because of high cross talk noise arising in the retrieval for finite sizes. Here a new bidirectional iterative retrieval method for the Willshaw model is presented, called crosswise bidirectional (CB)retrieval, providing enhanced performance. We discuss its asymptotic capacity limit, analyze the first step, and compare itin experiments with the Willshaw model. Applying the very efficient CB memory model either in information retrieval systems or as a functional model for reciprocal cortico-cortical pathways requires more than robustness against random noise in the input: Our experiments show also the segmentation ability of CB-retrieval with addresses containing the superposition of pattens, provided even at high memory load. 1 INTRODUCTION From a technical point of view neural associative memories (NAM) provide data storage and retrieval.

Selective suppression of transmission at feedback synapses during learning is proposed as a mechanism for combining associative feedback with self-organization of feed forward synapses. Experimental data demonstrates cholinergic suppression of synaptic transmission in layer I (feedback synapses), and a lack of suppression in layer IV (feedforward synapses). A network with this feature uses local rules to learn mappings which are not linearly separable. During learning, sensory stimuli and desired response are simultaneously presented as input. Feedforward connections form self-organized representations of input, while suppressed feedback connections learn the transpose of feedforward connectivity. During recall, suppression is removed, sensory input activates the self-organized representation, and activity generates the learned response.

Selective suppression of transmission at feedback synapses during learning is proposed as a mechanism for combining associative feedback with self-organization of feed forward synapses. Experimental data demonstrates cholinergic suppression of synaptic transmission in layer I (feedback synapses), and a lack of suppression in layer IV (feedforward synapses). A network with this feature uses local rules to learn mappings which are not linearly separable. During learning, sensory stimuli and desired response are simultaneously presented as input. Feedforward connections form self-organized representations of input, while suppressed feedback connections learn the transpose of feedforward connectivity. During recall, suppression is removed, sensory input activates the self-organized representation, and activity generates the learned response.

Selective suppression of transmission at feedback synapses during learning is proposed as a mechanism for combining associative feedback withself-organization of feedforward synapses. Experimental data demonstrates cholinergic suppression of synaptic transmission in layer I (feedback synapses), and a lack of suppression in layer IV (feedforward synapses).A network with this feature uses local rules to learn mappings which are not linearly separable. During learning, sensory stimuli and desired response are simultaneously presented as input. Feedforward connections form self-organized representations of input, while suppressed feedback connections learn the transpose of feedforward connectivity.During recall, suppression is removed, sensory input activates the self-organized representation, and activity generates the learned response.

A model of the hippocampus is presented which forms rapid self -organized representations of input arriving via the perforant path, performs recall of previous associations in region CA3, and performs comparison of this recall with afferent input in region CA 1. This comparison drives feedback regulation of cholinergic modulation to set appropriate dynamics for learning of new representations in region CA3 and CA 1. The network responds to novel patterns with increased cholinergic modulation, allowing storage of new self-organized representations, but responds to familiar patterns with a decrease in acetylcholine, allowing recall based on previous representations. This requires selectivity of the cholinergic suppression of synaptic transmission in stratum radiatum of regions CA3 and CAl, which has been demonstrated experimentally. 1 INTRODUCTION A number of models of hippocampal function have been developed (Burgess et aI., 1994; Myers and Gluck, 1994; Touretzky et al., 1994), but remarkably few simulations have addressed hippocampal function within the constraints provided by physiological and anatomical data. Theories of the function of specific subregions of the hippocampal formation often do not address physiological mechanisms for changing dynamics between learning of novel stimuli and recall of familiar stimuli.

A model of the hippocampus is presented which forms rapid self -organized representations of input arriving via the perforant path, performs recall of previous associations in region CA3, and performs comparison of this recall with afferent input in region CA 1. This comparison drives feedback regulation of cholinergic modulation to set appropriate dynamics for learning of new representations in region CA3 and CA 1. The network responds to novel patterns with increased cholinergic modulation, allowing storage of new self-organized representations, but responds to familiar patterns with a decrease in acetylcholine, allowing recall based on previous representations. This requires selectivity of the cholinergic suppression of synaptic transmission in stratum radiatum of regions CA3 and CAl, which has been demonstrated experimentally. 1 INTRODUCTION A number of models of hippocampal function have been developed (Burgess et aI., 1994; Myers and Gluck, 1994; Touretzky et al., 1994), but remarkably few simulations have addressed hippocampal function within the constraints provided by physiological and anatomical data. Theories of the function of specific subregions of the hippocampal formation often do not address physiological mechanisms for changing dynamics between learning of novel stimuli and recall of familiar stimuli.

Four overlapping patterns (1-4) are presented sequentially.

The Hopfield network (Hopfield, 1982,1984) provides a simple model of an associative memory in a neuronal structure. This model, however, is based on highly artificial assumptions, especially the use of formal-two state neurons (Hopfield, 1982) or graded-response neurons (Hopfield, 1984).