Incorporating domain knowledge into the modeling process is an effective way to improve learning accuracy. However, as it is provided by humans, domain knowledge can only be specified with some degree of uncertainty. We propose to explicitly model such uncertainty through probabilistic constraints over the parameter space. In contrast to hard parameter constraints, our approach is effective also when the domain knowledge is inaccurate and generally results in superior modeling accuracy. We focus on generative and conditional modeling where the parameters are assigned a Dirichlet or Gaussian prior and demonstrate the framework with experiments on both synthetic and real-world data.

We outline a representation for discrete multivariate distributions in terms of interventional potential functions that are globally normalized. This representation can be used to model the effects of interventions, and the independence properties encoded in this model can be represented as a directed graph that allows cycles. In addition to discussing inference and sampling with this representation, we give an exponential family parametrization that allows parameter estimation to be stated as a convex optimization problem; we also give a convex relaxation of the task of simultaneous parameter and structure learning using group l1-regularization. The model is evaluated on simulated data and intracellular flow cytometry data.

Score matching is a recently developed parameter learning method that is particularly effective to complicated high dimensional density models with intractable partition functions. In this paper, we study two issues that have not been completely resolved for score matching. First, we provide a formal link between maximum likelihood and score matching. Our analysis shows that score matching finds model parameters that are more robust with noisy training data. Second, we develop a generalization of score matching. Based on this generalization, we further demonstrate an extension of score matching to models of discrete data.

We present the Infinite Latent Events Model, a nonparametric hierarchical Bayesian distribution over infinite dimensional Dynamic Bayesian Networks with binary state representations and noisy-OR-like transitions. The distribution can be used to learn structure in discrete timeseries data by simultaneously inferring a set of latent events, which events fired at each timestep, and how those events are causally linked. We illustrate the model on a sound factorization task, a network topology identification task, and a video game task.

This paper develops an inconsistency measure on conditional probabilistic knowledge bases. The measure is based on fundamental principles for inconsistency measures and thus provides a solid theoretical framework for the treatment of inconsistencies in probabilistic expert systems. We illustrate its usefulness and immediate application on several examples and present some formal results. Building on this measure we use the Shapley value-a well-known solution for coalition games-to define a sophisticated indicator that is not only able to measure inconsistencies but to reveal the causes of inconsistencies in the knowledge base. Altogether these tools guide the knowledge engineer in his aim to restore consistency and therefore enable him to build a consistent and usable knowledge base that can be employed in probabilistic expert systems.

Logical inference algorithms for conditional independence (CI) statements have important applications from testing consistency during knowledge elicitation to constraintbased structure learning of graphical models. We prove that the implication problem for CI statements is decidable, given that the size of the domains of the random variables is known and fixed. We will present an approximate logical inference algorithm which combines a falsification and a novel validation algorithm. The validation algorithm represents each set of CI statements as a sparse 0-1 matrix A and validates instances of the implication problem by solving specific linear programs with constraint matrix A. We will show experimentally that the algorithm is both effective and efficient in validating and falsifying instances of the probabilistic CI implication problem.

Continuous-time Bayesian networks is a natural structured representation language for multicomponent stochastic processes that evolve continuously over time. Despite the compact representation, inference in such models is intractable even in relatively simple structured networks. Here we introduce a mean field variational approximation in which we use a product of inhomogeneous Markov processes to approximate a distribution over trajectories. This variational approach leads to a globally consistent distribution, which can be efficiently queried. Additionally, it provides a lower bound on the probability of observations, thus making it attractive for learning tasks. We provide the theoretical foundations for the approximation, an efficient implementation that exploits the wide range of highly optimized ordinary differential equations (ODE) solvers, experimentally explore characterizations of processes for which this approximation is suitable, and show applications to a large-scale realworld inference problem.

A Bayesian belief network models a joint distribution with an directed acyclic graph representing dependencies among variables and network parameters characterizing conditional distributions. The parameters are viewed as random variables to quantify uncertainty about their values. Belief nets are used to compute responses to queries; i.e., conditional probabilities of interest. A query is a function of the parameters, hence a random variable. Van Allen et al. (2001, 2008) showed how to quantify uncertainty about a query via a delta method approximation of its variance. We develop more accurate approximations for both query mean and variance. The key idea is to extend the query mean approximation to a "doubled network" involving two independent replicates. Our method assumes complete data and can be applied to discrete, continuous, and hybrid networks (provided discrete variables have only discrete parents). We analyze several improvements, and provide empirical studies to demonstrate their effectiveness.

Computational analysis of time-course data with an underlying causal structure is needed in a variety of domains, including neural spike trains, stock price movements, and gene expression levels. However, it can be challenging to determine from just the numerical time course data alone what is coordinating the visible processes, to separate the underlying prima facie causes into genuine and spurious causes and to do so with a feasible computational complexity. For this purpose, we have been developing a novel algorithm based on a framework that combines notions of causality in philosophy with algorithmic approaches built on model checking and statistical techniques for multiple hypotheses testing. The causal relationships are described in terms of temporal logic formulae, reframing the inference problem in terms of model checking. The logic used, PCTL, allows description of both the time between cause and effect and the probability of this relationship being observed. We show that equipped with these causal formulae with their associated probabilities we may compute the average impact a cause makes to its effect and then discover statistically significant causes through the concepts of multiple hypothesis testing (treating each causal relationship as a hypothesis), and false discovery control. By exploring a well-chosen family of potentially all significant hypotheses with reasonably minimal description length, it is possible to tame the algorithm's computational complexity while exploring the nearly complete search-space of all prima facie causes. We have tested these ideas in a number of domains and illustrate them here with two examples.

As computer clusters become more common and the size of the problems encountered in the field of AI grows, there is an increasing demand for efficient parallel inference algorithms. We consider the problem of parallel inference on large factor graphs in the distributed memory setting of computer clusters. We develop a new efficient parallel inference algorithm, DBRSplash, which incorporates over-segmented graph partitioning, belief residual scheduling, and uniform work Splash operations. We empirically evaluate the DBRSplash algorithm on a 120 processor cluster and demonstrate linear to super-linear performance gains on large factor graph models.