We derive a plausible learning rule updating the synaptic efficacies for feedforward, feedback and lateral connections between observed and latent neurons. Operating in the context of a generative model for distributions of spike sequences, the learning mechanism is derived from variational inference principles. The synaptic plasticity rules found are interesting in that they are strongly reminiscent of experimentally found results on Spike Time Dependent Plasticity, and in that they differ for excitatory and inhibitory neurons. A simulation confirms the method's applicability to learning both stationary and temporal spike patterns.

Loopy belief propagation performs approximate inference on graphical models with loops. One might hope to compensate for the approximation by adjusting model parameters. Learning algorithms for this purpose have been explored previously, and the claim has been made that every set of locally consistent marginals can arise from belief propagation run on a graphical model. On the contrary, here we show that many probability distributions have marginals that cannot be reached by belief propagation using any set of model parameters or any learning algorithm. We call such marginals `unbelievable.' This problem occurs whenever the Hessian of the Bethe free energy is not positive-definite at the target marginals. All learning algorithms for belief propagation necessarily fail in these cases, producing beliefs or sets of beliefs that may even be worse than the pre-learning approximation. We then show that averaging inaccurate beliefs, each obtained from belief propagation using model parameters perturbed about some learned mean values, can achieve the unbelievable marginals.

We show an application of a tree structure for approximate inference in graphical models using the expectation propagation algorithm. These approximations are typically used over graphs with short-range cycles. We demonstrate that these approximations also help in sparse graphs with long-range loops, as the ones used in coding theory to approach channel capacity. For asymptotically large sparse graph, the expectation propagation algorithm together with the tree structure yields a completely disconnected approximation to the graphical model but, for for finite-length practical sparse graphs, the tree structure approximation to the code graph provides accurate estimates for the marginal of each variable. Furthermore, we propose a new method for constructing the tree structure on the fly that might be more amenable for sparse graphs with general factors.

Recently, Mahoney and Orecchia demonstrated that popular diffusion-based procedures to compute a quick approximation to the first nontrivial eigenvector of a data graph Laplacian exactly solve certain regularized Semi-Definite Programs (SDPs). In this paper, we extend that result by providing a statistical interpretation of their approximation procedure. Our interpretation will be analogous to the manner in which l2-regularized or l1-regularized l2 regression (often called Ridge regression and Lasso regression, respectively) can be interpreted in terms of a Gaussian prior or a Laplace prior, respectively, on the coefficient vector of the regression problem. Our framework will imply that the solutions to the Mahoney-Orecchia regularized SDP can be interpreted as regularized estimates of the pseudoinverse of the graph Laplacian. Conversely, it will imply that the solution to this regularized estimation problem can be computed very quickly by running, e.g., the fast diffusion-based PageRank procedure for computing an approximation to the first nontrivial eigenvector of the graph Laplacian. Empirical results are also provided to illustrate the manner in which approximate eigenvector computation implicitly performs statistical regularization, relative to running the corresponding exact algorithm.

Traditional approaches to probabilistic inference such as loopy belief propagation and Gibbs sampling typically compute marginals for it all the unobserved variables in a graphical model. However, in many real-world applications the user's interests are focused on a subset of the variables, specified by a query. In this case it would be wasteful to uniformly sample, say, one million variables when the query concerns only ten. In this paper we propose a query-specific approach to MCMC that accounts for the query variables and their generalized mutual information with neighboring variables in order to achieve higher computational efficiency. Surprisingly there has been almost no previous work on query-aware MCMC. We demonstrate the success of our approach with positive experimental results on a wide range of graphical models.

We introduce a variational Bayesian inference algorithm which can be widely applied to sparse linear models. The algorithm is based on the spike and slab prior which, from a Bayesian perspective, is the golden standard for sparse inference. We apply the method to a general multi-task and multiple kernel learning model in which a common set of Gaussian process functions is linearly combined with task-specific sparse weights, thus inducing relation between tasks. This model unifies several sparse linear models, such as generalized linear models, sparse factor analysis and matrix factorization with missing values, so that the variational algorithm can be applied to all these cases. We demonstrate our approach in multi-output Gaussian process regression, multi-class classification, image processing applications and collaborative filtering.

Variability in single neuron models is typically implemented either by a stochastic Leaky-Integrate-and-Fire model or by a model of the Generalized Linear Model (GLM) family. We use analytical and numerical methods to relate state-of-the-art models from both schools of thought. First we find the analytical expressions relating the subthreshold voltage from the Adaptive Exponential Integrate-and-Fire model (AdEx) to the Spike-Response Model with escape noise (SRM as an example of a GLM). Then we calculate numerically the link-function that provides the firing probability given a deterministic membrane potential. We find a mathematical expression for this link-function and test the ability of the GLM to predict the firing probability of a neuron receiving complex stimulation. Comparing the prediction performance of various link-functions, we find that a GLM with an exponential link-function provides an excellent approximation to the Adaptive Exponential Integrate-and-Fire with colored-noise input. These results help to understand the relationship between the different approaches to stochastic neuron models.

A Bayesian approach to partitioning distance matrices is presented. It is inspired by the 'Translation-Invariant Wishart-Dirichlet' process (TIWD) in (Vogt et al., 2010) and shares a number of advantageous properties like the fully probabilistic nature of the inference model, automatic selection of the number of clusters and applicability in semi-supervised settings. In addition, our method (which we call 'fastTIWD') overcomes the main shortcoming of the original TIWD, namely its high computational costs. The fastTIWD reduces the workload in each iteration of a Gibbs sampler from O(n^3) in the TIWD to O(n^2). Our experiments show that this cost reduction does not compromise the quality of the inferred partitions. With this new method it is now possible to 'mine' large relational datasets with a probabilistic model, thereby automatically detecting new and potentially interesting clusters.

An important task in exploring and analyzing real-world data sets is to detect unusual and interesting phenomena. In this paper, we study the group anomaly detection problem. Unlike traditional anomaly detection research that focuses on data points, our goal is to discover anomalous aggregated behaviors of groups of points. For this purpose, we propose the Flexible Genre Model (FGM). FGM is designed to characterize data groups at both the point level and the group level so as to detect various types of group anomalies. We evaluate the effectiveness of FGM on both synthetic and real data sets including images and turbulence data, and show that it is superior to existing approaches in detecting group anomalies.

Nonparametric Bayesian methods are developed for analysis of multi-channel spike-train data, with the feature learning and spike sorting performed jointly. The feature learning and sorting are performed simultaneously across all channels. Dictionary learning is implemented via the beta-Bernoulli process, with spike sorting performed via the dynamic hierarchical Dirichlet process (dHDP), with these two models coupled. The dHDP is augmented to eliminate refractory-period violations, it allows the "appearance" and "disappearance" of neurons over time, and it models smooth variation in the spike statistics.