Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of spatial context as information flows through the network. Incorporating contextual knowledge into predictions is particularly important given the inclination for cancerous cells to form clusters and the presence of spatial indicators for tumors. State-of-the-art methods often use attention mechanisms eventually combined with graphs to capture spatial knowledge. In this paper, we take a novel and transversal approach, addressing this issue through the lens of regularization. We propose Context-Aware Regularization for Multiple Instance Learning (CARMIL), a versatile regularization scheme designed to seamlessly integrate spatial knowledge into any MIL model. Additionally, we present a new and generic metric to quantify the Context-Awareness of any MIL model when applied to Whole Slide Images, resolving a previously unexplored gap in the field. The efficacy of our framework is evaluated for two survival analysis tasks on glioblastoma (TCGA GBM) and colon cancer data (TCGA COAD).

This study introduces a parameter-efficient Hierarchical Spatial Temporal Network (HiSTN) specifically designed for the task of emotion classification using multi-channel electroencephalogram data. The network incorporates a graph hierarchy constructed from bottom-up at various abstraction levels, offering the dual advantages of enhanced task-relevant deep feature extraction and a lightweight design. The model's effectiveness is further amplified when used in conjunction with a proposed unique label smoothing method. Comprehensive benchmark experiments reveal that this combined approach yields high, balanced performance in terms of both quantitative and qualitative predictions. HiSTN, which has approximately 1,000 parameters, achieves mean F1 scores of 96.82% (valence) and 95.62% (arousal) in subject-dependent tests on the rarely-utilized 5-classification task problem from the DREAMER dataset. In the subject-independent settings, the same model yields mean F1 scores of 78.34% for valence and 81.59% for arousal. The adoption of the Sequential Top-2 Hit Rate (Seq2HR) metric highlights the significant enhancements in terms of the balance between model's quantitative and qualitative for predictions achieved through our approach when compared to training with regular one-hot labels. These improvements surpass 50% in subject-dependent tasks and 30% in subject-independent tasks. The study also includes relevant ablation studies and case explorations to further elucidate the workings of the proposed model and enhance its interpretability.

Vehicle trajectories provide valuable movement information that supports various downstream tasks and powers real-world applications. A desirable trajectory learning model should transfer between different regions and tasks without retraining, thus improving computational efficiency and effectiveness with limited training data. However, a model's ability to transfer across regions is limited by the unique spatial features and POI arrangements of each region, which are closely linked to vehicle movement patterns and difficult to generalize. Additionally, achieving task transferability is challenging due to the differing generation schemes required for various tasks. Existing efforts towards transferability primarily involve learning embedding vectors for trajectories, which perform poorly in region transfer and still require retraining of prediction modules for task transfer. To address these challenges, we propose TrajFM, a vehicle trajectory foundation model that excels in both region and task transferability. For region transferability, we introduce STRFormer as the main learnable model within TrajFM. It integrates spatial, temporal, and POI modalities of trajectories to effectively manage variations in POI arrangements across regions and includes a learnable spatio-temporal Rotary position embedding module for handling spatial features. For task transferability, we propose a trajectory masking and recovery scheme. This scheme unifies the generation processes of various tasks into the masking and recovery of modalities and sub-trajectories, allowing TrajFM to be pre-trained once and transferred to different tasks without retraining. Experiments on two real-world vehicle trajectory datasets under various settings demonstrate the effectiveness of TrajFM. Code is available at https://anonymous.4open.science/r/TrajFM-30E4.

Accurate taxi-demand prediction is essential for optimizing taxi operations and enhancing urban transportation services. However, using customers' data in these systems raises significant privacy and security concerns. Traditional federated learning addresses some privacy issues by enabling model training without direct data exchange but often struggles with accuracy due to varying data distributions across different regions or service providers. In this paper, we propose CC-Net: a novel approach using collaborative learning enhanced with contrastive learning for taxi-demand prediction. Our method ensures high performance by enabling multiple parties to collaboratively train a demand-prediction model through hierarchical federated learning. In this approach, similar parties are clustered together, and federated learning is applied within each cluster. The similarity is defined without data exchange, ensuring privacy and security. We evaluated our approach using real-world data from five taxi service providers in Japan over fourteen months. The results demonstrate that CC-Net maintains the privacy of customers' data while improving prediction accuracy by at least 2.2% compared to existing techniques.

In the last two decades, with the increasing need to analyze big amounts of data, which are usually complex and of high dimension, it was revealed meaningful and helpful to discover further methodologies to provide new information from data. This has brought to the birth of Topological Data Analysis (TDA), whose aim is to extract intrinsic, topological features, related to the so-called "shape of data". Thanks to its main tool, Persistent Homology (PH), it can provide new qualitative information that it would be impossible to extract in any other way. These kinds of features that can be collected in the so-called Persistence Diagram (PD), have been winning in many different applications, mainly related to applied science, improving the performances of models or classifiers, as in our context. Thanks to the strong basis of algebraic topology behind it, the TDA is very versatile and can be applied to data with a priori any kind of structure, as we will explain in the following.

The objective of the panoramic activity recognition task is to identify behaviors at various granularities within crowded and complex environments, encompassing individual actions, social group activities, and global activities. Existing methods generally use either parameter-independent modules to capture task-specific features or parameter-sharing modules to obtain common features across all tasks. However, there is often a strong interrelatedness and complementary effect between tasks of different granularities that previous methods have yet to notice. In this paper, we propose a model called MPT-PAR that considers both the unique characteristics of each task and the synergies between different tasks simultaneously, thereby maximizing the utilization of features across multi-granularity activity recognition. Furthermore, we emphasize the significance of temporal and spatial information by introducing a spatio-temporal relation-enhanced module and a scene representation learning module, which integrate the the spatio-temporal context of action and global scene into the feature map of each granularity. Our method achieved an overall F1 score of 47.5\% on the JRDB-PAR dataset, significantly outperforming all the state-of-the-art methods.

We publicly release OpenUAS, a dataset of area embeddings based on urban usage patterns, including embeddings for over 1.3 million 50-meter square meshes covering a total area of 3,300 square kilometers. This dataset is valuable for analyzing area functions in fields such as market analysis, urban planning, transportation infrastructure, and infection prediction. It captures the characteristics of each area in the city, such as office districts and residential areas, by employing an area embedding technique that utilizes location information typically obtained by GPS. Numerous area embedding techniques have been proposed, and while the public release of such embedding datasets is technically feasible, it has not been realized. One of the obstacles has been the integration of data from different cities and periods into a unified space without sharing raw location data. We address this issue by developing an anchoring method that establishes anchors within a shared embedding space. We publicly release this anchor dataset along with area embedding datasets from several periods in eight major Japanese cities. This dataset allows users to analyze urban usage patterns in Japanese cities and embed their urban dataset into the same embedding space using the anchoring method. Our key contributions include the development of the anchoring method, releasing area embedding datasets for Japanese cities, and providing tools for effective data utilization.

Spatial transcriptomics data is invaluable for understanding the spatial organization of gene expression in tissues. There have been consistent efforts in studying how to effectively utilize the associated spatial information for refining gene expression modeling. We introduce a class of distance-preserving generative models for spatial transcriptomics, which utilizes the provided spatial information to regularize the learned representation space of gene expressions to have a similar pair-wise distance structure. This helps the latent space to capture meaningful encodings of genes in spatial proximity. We carry out theoretical analysis over a tractable loss function for this purpose and formalize the overall learning objective as a regularized evidence lower bound. Our framework grants compatibility with any variational-inference-based generative models for gene expression modeling. Empirically, we validate our proposed method on the mouse brain tissues Visium dataset and observe improved performance with variational autoencoders and scVI used as backbone models.

The segmentation of ultra-high resolution images poses challenges such as loss of spatial information or computational inefficiency. In this work, a novel approach that combines encoder-decoder architectures with domain decomposition strategies to address these challenges is proposed. Specifically, a domain decomposition-based U-Net (DDU-Net) architecture is introduced, which partitions input images into non-overlapping patches that can be processed independently on separate devices. A communication network is added to facilitate inter-patch information exchange to enhance the understanding of spatial context. Experimental validation is performed on a synthetic dataset that is designed to measure the effectiveness of the communication network. Then, the performance is tested on the DeepGlobe land cover classification dataset as a real-world benchmark data set. The results demonstrate that the approach, which includes inter-patch communication for images divided into $16\times16$ non-overlapping subimages, achieves a $2-3\,\%$ higher intersection over union (IoU) score compared to the same network without inter-patch communication. The performance of the network which includes communication is equivalent to that of a baseline U-Net trained on the full image, showing that our model provides an effective solution for segmenting ultra-high-resolution images while preserving spatial context. The code is available at https://github.com/corne00/HiRes-Seg-CNN.

Human Activity Recognition (HAR) is a field of study that focuses on identifying and classifying human activities. Skeleton-based Human Activity Recognition has received much attention in recent years, where Graph Convolutional Network (GCN) based method is widely used and has achieved remarkable results. However, the representation of skeleton data and the issue of over-smoothing in GCN still need to be studied. 1). Compared to central nodes, edge nodes can only aggregate limited neighbor information, and different edge nodes of the human body are always structurally related. However, the information from edge nodes is crucial for fine-grained activity recognition. 2). The Graph Convolutional Network suffers from a significant over-smoothing issue, causing nodes to become increasingly similar as the number of network layers increases. Based on these two ideas, we propose a two-stream graph convolution method called Spatial-Structural GCN (SpSt-GCN). Spatial GCN performs information aggregation based on the topological structure of the human body, and structural GCN performs differentiation based on the similarity of edge node sequences. The spatial connection is fixed, and the human skeleton naturally maintains this topology regardless of the actions performed by humans. However, the structural connection is dynamic and depends on the type of movement the human body is performing. Based on this idea, we also propose an entirely data-driven structural connection, which greatly increases flexibility. We evaluate our method on two large-scale datasets, i.e., NTU RGB+D and NTU RGB+D 120. The proposed method achieves good results while being efficient.