In mixed reality applications, a realistic acoustic experience in spatial environments is as crucial as the visual experience for achieving true immersion. Despite recent advances in neural approaches for Room Impulse Response (RIR) estimation, most existing methods are limited to the single environment on which they are trained, lacking the ability to generalize to new rooms with different geometries and surface materials. We aim to develop a unified model capable of reconstructing the spatial acoustic experience of any environment with minimum additional measurements. To this end, we present xRIR, a framework for cross-room RIR prediction. The core of our generalizable approach lies in combining a geometric feature extractor, which captures spatial context from panorama depth images, with a RIR encoder that extracts detailed acoustic features from only a few reference RIR samples. To evaluate our method, we introduce ACOUSTICROOMS, a new dataset featuring high-fidelity simulation of over 300,000 RIRs from 260 rooms. Experiments show that our method strongly outperforms a series of baselines. Furthermore, we successfully perform sim-to-real transfer by evaluating our model on four real-world environments, demonstrating the generalizability of our approach and the realism of our dataset.

Many real world tasks where Large Language Models (LLMs) can be used require spatial reasoning, like Point of Interest (POI) recommendation and itinerary planning. However, on their own LLMs lack reliable spatial reasoning capabilities, especially about distances. To address this problem, we develop a novel approach, DistRAG, that enables an LLM to retrieve relevant spatial information not explicitly learned during training. Our method encodes the geodesic distances between cities and towns in a graph and retrieves a context subgraph relevant to the question. Using this technique, our method enables an LLM to answer distance-based reasoning questions that it otherwise cannot answer. Given the vast array of possible places an LLM could be asked about, DistRAG offers a flexible first step towards providing a rudimentary `world model' to complement the linguistic knowledge held in LLMs.

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns.

The hippocampus enables spatial navigation through place cell populations forming cognitive maps. We propose proximity-preserving neural embeddings to encode multi-scale random walk transitions, where the inner product $\langle h(x, t), h(y, t) \rangle = q(y|x, t)$ represents normalized transition probabilities, with $h(x, t)$ as the embedding at location $x$ and $q(y|x, t)$ as the transition probability at scale $\sqrt{t}$. This scale hierarchy mirrors hippocampal dorsoventral organization. The embeddings $h(x, t)$ reduce pairwise spatial proximity into an environmental map, with Euclidean distances preserving proximity information. We use gradient ascent on $q(y|x, t)$ for straight-forward path planning, employing adaptive scale selection for trap-free, smooth trajectories, equivalent to minimizing embedding space distances. Matrix squaring ($P_{2t} = P_t^2$) efficiently builds global transitions from local ones ($P_1$), enabling preplay-like shortcut prediction. Experiments demonstrate localized place fields, multi-scale tuning, adaptability, and remapping, achieving robust navigation in complex environments. Our biologically plausible framework, extensible to theta-phase precession, unifies spatial and temporal coding for scalable navigation.

Multimodal Large Language Models (MLLMs) have demonstrated impressive performance in general vision-language tasks. However, recent studies have exposed critical limitations in their spatial reasoning capabilities. This deficiency in spatial reasoning significantly constrains MLLMs' ability to interact effectively with the physical world, thereby limiting their broader applications. We argue that spatial reasoning capabilities will not naturally emerge from merely scaling existing architectures and training methodologies. Instead, this challenge demands dedicated attention to fundamental modifications in the current MLLM development approach. In this position paper, we first establish a comprehensive framework for spatial reasoning within the context of MLLMs. We then elaborate on its pivotal role in real-world applications. Through systematic analysis, we examine how individual components of the current methodology, from training data to reasoning mechanisms, influence spatial reasoning capabilities. This examination reveals critical limitations while simultaneously identifying promising avenues for advancement. Our work aims to direct the AI research community's attention toward these crucial yet underexplored aspects. By highlighting these challenges and opportunities, we seek to catalyze progress toward achieving human-like spatial reasoning capabilities in MLLMs.

BlackSky introduces Smartflow, a cloud-based framework enabling scalable spatiotemporal geospatial research built on open-source tools and technologies. Using STAC-compliant catalogs as a common input, heterogeneous geospatial data can be processed into standardized datacubes for analysis and model training. Model experimentation is managed using a combination of tools, including ClearML, Tensorboard, and Apache Superset. Underpinning Smartflow is Kubernetes, which orchestrates the provisioning and execution of workflows to support both horizontal and vertical scalability. This combination of features makes Smartflow well-suited for geospatial model development and analysis over large geographic areas, time scales, and expansive image archives. We also present a novel neural architecture, built using Smartflow, to monitor large geographic areas for heavy construction. Qualitative results based on data from the IARPA Space-based Machine Automated Recognition Technique (SMART) program are presented that show the model is capable of detecting heavy construction throughout all major phases of development.

Spatial representations that capture both structural and semantic characteristics of urban environments are essential for urban modeling. Traditional spatial embeddings often prioritize spatial proximity while underutilizing fine-grained contextual information from places. To address this limitation, we introduce CaLLiPer+, an extension of the CaLLiPer model that systematically integrates Point-of-Interest (POI) names alongside categorical labels within a multimodal contrastive learning framework. We evaluate its effectiveness on two downstream tasks, land use classification and socioeconomic status distribution mapping, demonstrating consistent performance gains of 4% to 11% over baseline methods. Additionally, we show that incorporating POI names enhances location retrieval, enabling models to capture complex urban concepts with greater precision. Ablation studies further reveal the complementary role of POI names and the advantages of leveraging pretrained text encoders for spatial representations. Overall, our findings highlight the potential of integrating fine-grained semantic attributes and multimodal learning techniques to advance the development of urban foundation models.

Generalized policy and execution efficiency constitute the two critical challenges in robotic manipulation. While recent foundation policies benefit from the common-sense reasoning capabilities of internet-scale pretrained vision-language models (VLMs), they often suffer from low execution frequency. To mitigate this dilemma, dual-system approaches, inspired by Kahneman's theory, have been proposed to leverage a VLM-based System 2 model handling high-level reasoning and a separate System 1 action model ensuring real-time control. However, existing designs maintain both systems as separate models, limiting System 1 from fully leveraging the rich pretrained knowledge from the VLM-based System 2. In this work, we propose Fast-in-Slow (FiS), a unified dual-system vision-language-action (VLA) model that embeds the System 1 execution module within the VLM-based System 2 by partially sharing parameters. This innovative paradigm not only enables high-frequency execution in System 1 but also facilitates coordination between the reasoning and execution components within a single foundation model of System 2. Given their fundamentally distinct roles within FiS-VLA, we design the two systems to incorporate heterogeneous modality inputs alongside asynchronous operating frequencies, enabling both fast and precise manipulation. To enable coordination between the two systems, a dual-aware co-training strategy is proposed that equips System 1 with action generation capabilities while preserving System 2's contextual reasoning representation. For evaluation, FiS-VLA outperforms previous state-of-the-art methods by 8% in simulation and 11% in real-world tasks in terms of average success rate, while achieving a 117.7 Hz control frequency with action chunk set to eight. Project web page: fast-in-slow.github.io.

Image mass cytometry (IMC) enables high-dimensional spatial profiling by combining mass cytometry's analytical power with spatial distributions of cell phenotypes. Recent studies leverage large language models (LLMs) to extract cell states by translating gene or protein expression into biological context. However, existing single-cell LLMs face two major challenges: (1) Integration of spatial information: they struggle to generalize spatial coordinates and effectively encode spatial context as text, and (2) Treating each cell independently: they overlook cell-cell interactions, limiting their ability to capture biological relationships. To address these limitations, we propose Spatial2Sentence, a novel framework that integrates single-cell expression and spatial information into natural language using a multi-sentence approach. Spatial2Sentence constructs expression similarity and distance matrices, pairing spatially adjacent and expressionally similar cells as positive pairs while using distant and dissimilar cells as negatives. These multi-sentence representations enable LLMs to learn cellular interactions in both expression and spatial contexts. Equipped with multi-task learning, Spatial2Sentence outperforms existing single-cell LLMs on preprocessed IMC datasets, improving cell-type classification by 5.98% and clinical status prediction by 4.18% on the diabetes dataset while enhancing interpretability. The source code can be found here: https://github.com/UNITES-Lab/Spatial2Sentence.

Autonomous operation of service robotics in human-centric scenes remains challenging due to the need for understanding of changing environments and context-aware decision-making. While existing approaches like topological maps offer efficient spatial priors, they fail to model transient object relationships, whereas dense neural representations (e.g., NeRF) incur prohibitive computational costs. Inspired by the hierarchical scene representation and video scene graph generation works, we propose Hi-Dyna Graph, a hierarchical dynamic scene graph architecture that integrates persistent global layouts with localized dynamic semantics for embodied robotic autonomy. Our framework constructs a global topological graph from posed RGB-D inputs, encoding room-scale connectivity and large static objects (e.g., furniture), while environmental and egocentric cameras populate dynamic subgraphs with object position relations and human-object interaction patterns. A hybrid architecture is conducted by anchoring these subgraphs to the global topology using semantic and spatial constraints, enabling seamless updates as the environment evolves. An agent powered by large language models (LLMs) is employed to interpret the unified graph, infer latent task triggers, and generate executable instructions grounded in robotic affordances. We conduct complex experiments to demonstrate Hi-Dyna Grap's superior scene representation effectiveness. Real-world deployments validate the system's practicality with a mobile manipulator: robotics autonomously complete complex tasks with no further training or complex rewarding in a dynamic scene as cafeteria assistant. See https://anonymous.4open.science/r/Hi-Dyna-Graph-B326 for video demonstration and more details.