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Drug recommendation systems aim to identify optimal drug combinations for patient care, balancing therapeutic efficacy and safety. Advances in large-scale longitudinal EHRs have enabled learning-based approaches that leverage patient histories such as diagnoses, procedures, and previously prescribed drugs, to model complex patient-drug relationships. Yet, many existing solutions overlook standard clinical practices that favor certain drugs for specific conditions and fail to fully integrate the influence of molecular substructures on drug efficacy and safety. In response, we propose SubRec, a unified framework that integrates representation learning across both patient and drug spaces. Specifically, SubRec introduces a conditional information bottleneck to extract core drug substructures most relevant to patient conditions, thereby enhancing interpretability and clinical alignment. Meanwhile, an adaptive vector quantization mechanism is designed to generate patient-drug interaction patterns into a condition-aware codebook which reuses clinically meaningful patterns, reduces training overhead, and provides a controllable latent space for recommendation. Crucially, the synergy between condition-specific substructure learning and discrete patient prototypes allows SubRec to make accurate and personalized drug recommendations. Experimental results on the real-world MIMICIII and IV demonstrate our model's advantages. The source code is available at https://DrugRecommendation/.

Upgrades include 360-degree audio and deeper integration with Gemini. Last fall Google teased that it was working on an all-new Google Home speaker due out sometime in mid 2026. And while it took a tiny bit longer than expected, today the company began taking pre-orders for its latest speaker ahead of its official on-sale date of June 25. While the new Google Home serves a similar role to the existing Nest Audio, including the ability to function as linked stereo speakers when paired with a second unit, there are a number of other design changes and upgrades. Instead of relying on directional sound, the Google Home was created to deliver clear 360-degree audio in an even more compact chassis.

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Graph Machine Learning is essential for understanding and analyzing relational data. However, privacy-sensitive applications demand the ability to efficiently remove sensitive information from trained graph neural networks (GNNs), avoiding the unnecessary time and space overhead caused by retraining models from scratch. To address this issue, Graph Unlearning (GU) has emerged as a critical solution to support dynamic graph updates while ensuring privacy compliance. Unlike machine unlearning in computer vision or other fields, GU faces unique difficulties due to the non-Euclidean nature of graph data and the recursive message-passing mechanism of GNNs. Additionally, the diversity of downstream tasks and the complexity of unlearning requests further amplify these challenges. Despite the proliferation of diverse GU strategies, the absence of a benchmark providing fair comparisons for GU, and the limited flexibility in combining downstream tasks and unlearning requests, have yielded inconsistencies in evaluations, hindering the development of this domain. To fill this gap, we present OpenGU, the first GU benchmark, where 16 SOTAGU algorithms and 37 multi-domain datasets are integrated, enabling various downstream tasks with 13 GNN backbones when responding to flexible unlearning requests. Through extensive experimentation, we have drawn 10crucial conclusions about existing GU methods, while also gaining valuable insights into their limitations, shedding light on potential avenues for future research.

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We study a two-institution stable matching model in which candidates from two distinct groups are evaluated using partially correlated signals that are groupbiased. This extends prior work (which assumes institutions evaluate candidates in an identical manner) to a more realistic setting in which institutions rely on overlapping, but independently processed, criteria. These evaluations could consist of a variety of informative tools such as standardized tests, shared recommendation systems, or AI-based assessments with local noise. Two key parameters govern evaluations: the bias parameter β (0,1], which models systematic disadvantage faced by one group, and the correlation parameter γ [0,1], which captures the alignment between institutional rankings. We study the representation ratio R(β,γ), i.e., the ratio of disadvantaged to advantaged candidates selected by the matching process in this setting.