As a leading cause of mortality among women globally, the precise and timely diagnosis of breast cancer remains imperative for optimizing patient outcomes. While traditional diagnostic methodologies [2] have historically relied heavily on uni-modal approaches, the evolving landscape of medical data analytics underscores the significance of integrating diverse data sources beyond conventional imaging modalities [3]. Figure 1 illustrates a generic model for breast cancer diagnosis within the Computer-Aided Detection (CAD) framework. As depicted in Figure 2, breast cancer detection can be performed using various data types, employing either unimodal or multimodal approaches. The process initiates with data pre-processing, followed by feature extraction. To enhance the learning of feature representations from image data, segmentation may be conducted prior to feature extraction. Subsequently, the detection model is applied to generate a diagnosis from the processed data. Based on this diagnosis, further analyses are performed, including sub-type classification, grade classification, recurrence and metastasis prediction, as well as the incorporation of crowdsourcing and human-in-the-loop methodologies. These steps culminate in a final decision that informs subsequent treatment and monitoring strategies.

Fault detection is crucial in industrial systems to prevent failures and optimize performance by distinguishing abnormal from normal operating conditions. Data-driven methods have been gaining popularity for fault detection tasks as the amount of condition monitoring data from complex industrial systems increases. Despite these advances, early fault detection remains a challenge under real-world scenarios. The high variability of operating conditions and environments makes it difficult to collect comprehensive training datasets that can represent all possible operating conditions, especially in the early stages of system operation. Furthermore, these variations often evolve over time, potentially leading to entirely new data distributions in the future that were previously unseen. These challenges prevent direct knowledge transfer across different units and over time, leading to the distribution gap between training and testing data and inducing performance degradation of those methods in real-world scenarios. To overcome this, our work introduces a novel approach for continuous test-time domain adaptation. This enables early-stage robust anomaly detection by addressing domain shifts and limited data representativeness issues. We propose a Test-time domain Adaptation Anomaly Detection (TAAD) framework that separates input variables into system parameters and measurements, employing two domain adaptation modules to independently adapt to each input category. This method allows for effective adaptation to evolving operating conditions and is particularly beneficial in systems with scarce data. Our approach, tested on a real-world pump monitoring dataset, shows significant improvements over existing domain adaptation methods in fault detection, demonstrating enhanced accuracy and reliability.

We study a specific type of SCM, called a Dynamic Structural Causal Model (DSCM), whose endogenous variables represent functions of time, which is possibly cyclic and allows for latent confounding. As a motivating use-case, we show that certain systems of Stochastic Differential Equations (SDEs) can be appropriately represented with DSCMs. An immediate consequence of this construction is a graphical Markov property for systems of SDEs. We define a time-splitting operation, allowing us to analyse the concept of local independence (a notion of continuous-time Granger (non-)causality). We also define a subsampling operation, which returns a discrete-time DSCM, and which can be used for mathematical analysis of subsampled time-series. We give suggestions how DSCMs can be used for identification of the causal effect of time-dependent interventions, and how existing constraint-based causal discovery algorithms can be applied to time-series data.

SARS-CoV-2, the highly contagious pathogen responsible for the COVID-19 pandemic, has persistent effects that begin four weeks after initial infection and last for an undetermined duration. These chronic effects are more harmful than acute ones. This review explores the long-term impact of the virus on various human organs, including the pulmonary, cardiovascular, neurological, reproductive, gastrointestinal, musculoskeletal, endocrine, and lymphoid systems, particularly in older adults. Regarding diagnosis, RT-PCR is the gold standard for detecting COVID-19, though it requires specialized equipment, skilled personnel, and considerable time to produce results. To address these limitations, artificial intelligence in imaging and microfluidics technologies offers promising alternatives for diagnosing COVID-19 efficiently. Pharmacological and non-pharmacological strategies are effective in mitigating the persistent impacts of COVID-19. These strategies enhance immunity in post-COVID-19 patients by reducing cytokine release syndrome, improving T cell response, and increasing the circulation of activated natural killer and CD8 T cells in blood and tissues. This, in turn, alleviates symptoms such as fever, nausea, fatigue, muscle weakness, and pain. Vaccines, including inactivated viral, live attenuated viral, protein subunit, viral vectored, mRNA, DNA, and nanoparticle vaccines, significantly reduce the adverse long-term effects of the virus. However, no vaccine has been reported to provide lifetime protection against COVID-19. Consequently, protective measures such as physical distancing, mask usage, and hand hygiene remain essential strategies. This review offers a comprehensive understanding of the persistent effects of COVID-19 on individuals of varying ages, along with insights into diagnosis, treatment, vaccination, and future preventative measures against the spread of SARS-CoV-2.

The need for modelling causal knowledge at different levels of granularity arises in several settings. Causal Abstraction provides a framework for formalizing this problem by relating two Structural Causal Models at different levels of detail. Despite increasing interest in applying causal abstraction, e.g. in the interpretability of large machine learning models, the graphical and parametrical conditions under which a causal model can abstract another are not known. Furthermore, learning causal abstractions from data is still an open problem. In this work, we tackle both issues for linear causal models with linear abstraction functions. First, we characterize how the low-level coefficients and the abstraction function determine the high-level coefficients and how the high-level model constrains the causal ordering of low-level variables. Then, we apply our theoretical results to learn high-level and low-level causal models and their abstraction function from observational data. In particular, we introduce Abs-LiNGAM, a method that leverages the constraints induced by the learned high-level model and the abstraction function to speedup the recovery of the larger low-level model, under the assumption of non-Gaussian noise terms. In simulated settings, we show the effectiveness of learning causal abstractions from data and the potential of our method in improving scalability of causal discovery.

Modern industrial fault diagnosis tasks often face the combined challenge of distribution discrepancy and bi-imbalance. Existing domain adaptation approaches pay little attention to the prevailing bi-imbalance, leading to poor domain adaptation performance or even negative transfer. In this work, we propose a self-degraded contrastive domain adaptation (Sd-CDA) diagnosis framework to handle the domain discrepancy under the bi-imbalanced data. It first pre-trains the feature extractor via imbalance-aware contrastive learning based on model pruning to learn the feature representation efficiently in a self-supervised manner. Then it forces the samples away from the domain boundary based on supervised contrastive domain adversarial learning (SupCon-DA) and ensures the features generated by the feature extractor are discriminative enough. Furthermore, we propose the pruned contrastive domain adversarial learning (PSupCon-DA) to pay automatically re-weighted attention to the minorities to enhance the performance towards bi-imbalanced data. We show the superiority of the proposed method via two experiments.

Linear non-Gaussian causal models postulate that each random variable is a linear function of parent variables and non-Gaussian exogenous error terms. We study identification of the linear coefficients when such models contain latent variables. Our focus is on the commonly studied acyclic setting, where each model corresponds to a directed acyclic graph (DAG). For this case, prior literature has demonstrated that connections to overcomplete independent component analysis yield effective criteria to decide parameter identifiability in latent variable models. However, this connection is based on the assumption that the observed variables linearly depend on the latent variables. Departing from this assumption, we treat models that allow for arbitrary non-linear latent confounding. Our main result is a graphical criterion that is necessary and sufficient for deciding the generic identifiability of direct causal effects. Moreover, we provide an algorithmic implementation of the criterion with a run time that is polynomial in the number of observed variables. Finally, we report on estimation heuristics based on the identification result, explore a generalization to models with feedback loops, and provide new results on the identifiability of the causal graph.

Industrial equipment fault diagnosis often encounter challenges such as the scarcity of fault data, complex operating conditions, and varied types of failures. Signal analysis, data statistical learning, and conventional deep learning techniques face constraints under these conditions due to their substantial data requirements and the necessity for transfer learning to accommodate new failure modes. To effectively leverage information and extract the intrinsic characteristics of faults across different domains under limited sample conditions, this paper introduces a fault diagnosis approach employing Multi-Scale Graph Convolution Filtering (MSGCF). MSGCF enhances the traditional Graph Neural Network (GNN) framework by integrating both local and global information fusion modules within the graph convolution filter block. This advancement effectively mitigates the over-smoothing issue associated with excessive layering of graph convolutional layers while preserving a broad receptive field. It also reduces the risk of overfitting in few-shot diagnosis, thereby augmenting the model's representational capacity. Experiments on the University of Paderborn bearing dataset (PU) demonstrate that the MSGCF method proposed herein surpasses alternative approaches in accuracy, thereby offering valuable insights for industrial fault diagnosis in few-shot learning scenarios.

In the emergency department (ED), patients undergo triage and multiple laboratory tests before diagnosis. This time-consuming process causes ED crowding which impacts patient mortality, medical errors, staff burnout, etc. This work proposes (time) cost-effective diagnostic assistance that leverages artificial intelligence systems to help ED clinicians make efficient and accurate diagnoses. In collaboration with ED clinicians, we use public patient data to curate MIMIC-ED-Assist, a benchmark for AI systems to suggest laboratory tests that minimize wait time while accurately predicting critical outcomes such as death. With MIMIC-ED-Assist, we develop ED-Copilot which sequentially suggests patient-specific laboratory tests and makes diagnostic predictions. ED-Copilot employs a pre-trained bio-medical language model to encode patient information and uses reinforcement learning to minimize ED wait time and maximize prediction accuracy. On MIMIC-ED-Assist, ED-Copilot improves prediction accuracy over baselines while halving average wait time from four hours to two hours. ED-Copilot can also effectively personalize treatment recommendations based on patient severity, further highlighting its potential as a diagnostic assistant. Since MIMIC-ED-Assist is a retrospective benchmark, ED-Copilot is restricted to recommend only observed tests. We show ED-Copilot achieves competitive performance without this restriction as the maximum allowed time increases. Our code is available at https://github.com/cxcscmu/ED-Copilot.

The unique challenges posed by the space environment, characterized by extreme conditions and limited accessibility, raise the need for robust and reliable techniques to identify and prevent satellite faults. Fault detection methods in the space sector are required to ensure mission success and to protect valuable assets. In this context, this paper proposes an Artificial Intelligence (AI) based fault detection methodology and evaluates its performance on ADAPT (Advanced Diagnostics and Prognostics Testbed), an Electrical Power System (EPS) dataset, crafted in laboratory by NASA. Our study focuses on the application of a physics-informed (PI) real-valued non-volume preserving (Real NVP) model for fault detection in space systems. The efficacy of this method is systematically compared against other AI approaches such as Gated Recurrent Unit (GRU) and Autoencoder-based techniques. Results show that our physics-informed approach outperforms existing methods of fault detection, demonstrating its suitability for addressing the unique challenges of satellite EPS sub-system faults. Furthermore, we unveil the competitive advantage of physics-informed loss in AI models to address specific space needs, namely robustness, reliability, and power constraints, crucial for space exploration and satellite missions.