Multi-layered distributed representation is believed to be the key ingredient of deep neural networks especially in cognitive tasks like computer vision. While non-differentiable models such as gradient boosting decision trees (GBDTs) are still the dominant methods for modeling discrete or tabular data, they are hard to incorporate with such representation learning ability. In this work, we propose the multi-layered GBDT forest (mGBDTs), with an explicit emphasis on exploring the ability to learn hierarchical distributed representations by stacking several layers of regression GBDTs as its building block. The model can be jointly trained by a variant of target propagation across layers, without the need to derive backpropagation nor differentiability. Experiments confirmed the effectiveness of the model in terms of performance and representation learning ability.

The emergence of vision-language models (VLMs) has opened new possibilities for clinical reasoning and has shown promising performance in dermatological diagnosis. However, their trustworthiness and clinical utility are often limited by three major factors: (1) Data heterogeneity, where diverse datasets lack consistent diagnostic labels and clinical concept annotations; (2) Absence of grounded diagnostic rationales, leading to a scarcity of reliable reasoning supervision; and (3) Limited scalability and generalization, as models trained on small, densely annotated datasets struggle to transfer nuanced reasoning to large, sparsely-annotated ones. To address these limitations, we propose SkinR1, a novel dermatological VLM that combines deep, textbook-based reasoning with the broad generalization capabilities of reinforcement learning (RL). SkinR1 systematically resolves the key challenges through a unified, end-to-end framework. First, we design a textbook-based reasoning generator that synthesizes high-fidelity, hierarchy-aware, and differential-diagnosis (DDx)-informed trajectories, providing reliable expert-level supervision. Second, we leverage the constructed trajectories for supervised fine-tuning (SFT) empowering the model with grounded reasoning ability. Third, we develop a novel RL paradigm that, by incorporating the hierarchical structure of diseases, effectively transfers these grounded reasoning patterns to large-scale, sparse data. Extensive experiments on multiple dermatology datasets demonstrate that SkinR1 achieves superior diagnostic accuracy. The ablation study demonstrates the importance of the reasoning foundation instilled by SFT.

W e assemble a large, domain - specialized clinical corpus and a clinician - validated reasoning set, and develop RareSeek - R1 via staged instruction tuning, chain - of - thought learning, and graph - grounded retrieval. Across multicenter EHR narratives and public benchmarks, RareSeek - R1 attains state - of - the - art accuracy, robust generalization, and stability under noisy or overlapping phenotypes. Augmented retrieval yields the largest gains when narratives pair with prioritized variants by resolving ambiguity and aligning candidates to mechanisms. Human studies show performance on par with experienced physicians and consistent gains in assistive use. Notably, transparent reasoning highlights decisive non - phenotypic evidence (median 23.1%, such as imaging, interventions, functional tests) underpinning many correct diagnoses. This work advances a narrative - first, knowledge - integrated reasoning paradigm that shortens the diagnostic odyssey and enables auditable, clinically translatable decision support.

AI tools in pathology have improved screening throughput, standardized quantification, and revealed prognostic patterns that inform treatment. However, adoption remains limited because most systems still lack the human-readable reasoning needed to audit decisions and prevent errors. We present RECAP-PATH, an interpretable framework that establishes a self-learning paradigm, shifting off-the-shelf multimodal large language models from passive pattern recognition to evidence-linked diagnostic reasoning. At its core is a two-phase learning process that autonomously derives diagnostic criteria: diversification expands pathology-style explanations, while optimization refines them for accuracy. This self-learning approach requires only small labeled sets and no white-box access or weight updates to generate cancer diagnoses. Evaluated on breast and prostate datasets, RECAP-PATH produced rationales aligned with expert assessment and delivered substantial gains in diagnostic accuracy over baselines. By uniting visual understanding with reasoning, RECAP-PATH provides clinically trustworthy AI and demonstrates a generalizable path toward evidence-linked interpretation.

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice. Diagnosis remains complex and error prone, especially in high-pressure or resource-limited settings, underscoring the need for frameworks that help clinicians make timely and cost-effective decisions. We propose ACTMED (Adaptive Clinical Test selection via Model-based Experimental Design), a diagnostic framework that integrates Bayesian Experimental Design (BED) with large language models (LLMs) to better emulate real-world diagnostic reasoning. At each step, ACTMED selects the test expected to yield the greatest reduction in diagnostic uncertainty for a given patient. LLMs act as flexible simulators, generating plausible patient state distributions and supporting belief updates without requiring structured, task-specific training data. Clinicians can remain in the loop; reviewing test suggestions, interpreting intermediate outputs, and applying clinical judgment throughout. We evaluate ACTMED on real-world datasets and show it can optimize test selection to improve diagnostic accuracy, interpretability, and resource use. This represents a step toward transparent, adaptive, and clinician-aligned diagnostic systems that generalize across settings with reduced reliance on domain-specific data.

As the use of AI in society grows, addressing emerging biases is essential to prevent systematic discrimination. Several bias detection methods have been proposed, but, with few exceptions, these tend to ignore transparency. Instead, interpretability and explainability are core requirements for algorithmic fairness, even more so than for other algorithmic solutions, given the human-oriented nature of fairness. We present ABIDE (Argumentative BIas detection by DEbate), a novel framework that structures bias detection transparently as debate, guided by an underlying argument graph as understood in (formal and computational) argumentation. The arguments are about the success chances of groups in local neighbourhoods and the significance of these neighbourhoods. We evaluate ABIDE experimentally and demonstrate its strengths in performance against an argumentative baseline.

Bolting operations are critical in industrial assembly and in the maintenance of scientific facilities, requiring high precision and robustness to faults. Although robotic solutions have the potential to improve operational safety and effectiveness, current systems still lack reliable autonomy and fault management capabilities. To address this gap, we propose a control framework for dependable robotized bolting tasks and instantiate it on a specific robotic system. The system features a control architecture ensuring accurate driving torque control and active compliance throughout the entire operation, enabling safe interaction even under fault conditions. By designing a multimodal human-robot interface (HRI) providing real-time visualization of relevant system information and supporting seamless transitions between automatic and manual control, we improve operator situation awareness and fault detection capabilities. A high-level supervisor (SV) coordinates the execution and manages transitions between control modes, ensuring consistency with the supervisory control (SVC) paradigm, while preserving the human operator's authority. The system is validated in a representative bolting operation involving pipe flange joining, under several fault conditions. The results demonstrate improved fault detection capabilities, enhanced operator situational awareness, and accurate and compliant execution of the bolting operation. However, they also reveal the limitations of relying on a single camera to achieve full situational awareness.

Solar thermal systems (STS) present a promising avenue for low-carbon heat generation, with a well-running system providing heat at minimal cost and carbon emissions. However, STS can exhibit faults due to improper installation, maintenance, or operation, often resulting in a substantial reduction in efficiency or even damage to the system. As monitoring at the individual level is economically prohibitive for small-scale systems, automated monitoring and fault detection should be used to address such issues. Recent advances in data-driven anomaly detection, particularly in time series analysis, offer a cost-effective solution by leveraging existing sensors to identify abnormal system states. Here, we propose a probabilistic reconstruction-based framework for anomaly detection. We evaluate our method on the publicly available PaSTS dataset of operational domestic STS, which features real-world complexities and diverse fault types. Our experiments show that reconstruction-based methods can detect faults in domestic STS both qualitatively and quantitatively, while generalizing to previously unseen systems. We also demonstrate that our model outperforms both simple and more complex deep learning baselines. Additionally, we show that heteroscedastic uncertainty estimation is essential to fault detection performance. Finally, we discuss the engineering overhead required to unlock these improvements and make a case for simple deep learning models.

Despite the advantages of multi-agent reinforcement learning (MARL) for wireless use case such as medium access control (MAC), their real-world deployment in Internet of Things (IoT) is hindered by their sample inefficiency. To alleviate this challenge, one can leverage model-based reinforcement learning (MBRL) solutions, however, conventional MBRL approaches rely on black-box models that are not interpretable and cannot reason. In contrast, in this paper, a novel causal model-based MARL framework is developed by leveraging tools from causal learn- ing. In particular, the proposed model can explicitly represent causal dependencies between network variables using structural causal models (SCMs) and attention-based inference networks. Interpretable causal models are then developed to capture how MAC control messages influence observations, how transmission actions determine outcomes, and how channel observations affect rewards. Data augmentation techniques are then used to generate synthetic rollouts using the learned causal model for policy optimization via proximal policy optimization (PPO). Analytical results demonstrate exponential sample complexity gains of causal MBRL over black-box approaches. Extensive simulations demonstrate that, on average, the proposed approach can reduce environment interactions by 58%, and yield faster convergence compared to model-free baselines. The proposed approach inherently is also shown to provide interpretable scheduling decisions via attention-based causal attribution, revealing which network conditions drive the policy. The resulting combination of sample efficiency and interpretability establishes causal MBRL as a practical approach for resource-constrained wireless systems.

Radiologists compose diagnostic reports through a structured workflow: they describe visual findings, summarize them into impressions, and carefully refine statements in clinically critical cases. However, most existing medical report generation (MRG) systems treat reports as flat sequences, overlooking this hierarchical organization and leading to inconsistencies between descriptive and diagnostic content. To align model behavior with real-world reporting practices, we propose RadFlow, a hierarchical workflow-guided reinforcement optimization framework that explicitly models the structured nature of clinical reporting. RadFlow introduces a clinically grounded reward hierarchy that mirrors the organization of radiological reports. At the global level, the reward integrates linguistic fluency, medical-domain correctness, and cross-sectional consistency between Finding and Impression, promoting coherent and clinically faithful narratives. At the local level, a section-specific reward emphasizes Impression quality, reflecting its central role in diagnostic accuracy. Furthermore, a critical-aware policy optimization mechanism adaptively regularizes learning for high-risk or clinically sensitive cases, emulating the cautious refinement behavior of radiologists when documenting critical findings. Together, these components translate the structured reporting paradigm into the reinforcement fine-tuning process, enabling the model to generate reports that are both linguistically consistent and clinically aligned. Experiments on chest X-ray and carotid ultrasound datasets demonstrate that RadFlow consistently improves diagnostic coherence and overall report quality compared with state-of-the-art baselines.