The utilization of deep learning on electrocardiogram (ECG) analysis has brought the advanced accuracy and efficiency of cardiac healthcare diagnostics. By leveraging the capabilities of deep learning in semantic understanding, especially in feature extraction and representation learning, this study introduces a new multimodal contrastive pretaining framework that aims to improve the quality and robustness of learned representations of 12-lead ECG signals. Our framework comprises two key components, including Cardio Query Assistant (CQA) and ECG Semantics Integrator(ESI). CQA integrates a retrieval-augmented generation (RAG) pipeline to leverage large language models (LLMs) and external medical knowledge to generate detailed textual descriptions of ECGs. The generated text is enriched with information about demographics and waveform patterns. ESI integrates both contrastive and captioning loss to pretrain ECG encoders for enhanced representations. We validate our approach through various downstream tasks, including arrhythmia detection and ECG-based subject identification. Our experimental results demonstrate substantial improvements over strong baselines in these tasks. These baselines encompass supervised and self-supervised learning methods, as well as prior multimodal pretraining approaches.

The mining of adverse drug events (ADEs) is pivotal in pharmacovigilance, enhancing patient safety by identifying potential risks associated with medications, facilitating early detection of adverse events, and guiding regulatory decision-making. Traditional ADE detection methods are reliable but slow, not easily adaptable to large-scale operations, and offer limited information. With the exponential increase in data sources like social media content, biomedical literature, and Electronic Medical Records (EMR), extracting relevant ADE-related information from these unstructured texts is imperative. Previous ADE mining studies have focused on text-based methodologies, overlooking visual cues, limiting contextual comprehension, and hindering accurate interpretation. To address this gap, we present a MultiModal Adverse Drug Event (MMADE) detection dataset, merging ADE-related textual information with visual aids. Additionally, we introduce a framework that leverages the capabilities of LLMs and VLMs for ADE detection by generating detailed descriptions of medical images depicting ADEs, aiding healthcare professionals in visually identifying adverse events. Using our MMADE dataset, we showcase the significance of integrating visual cues from images to enhance overall performance. This approach holds promise for patient safety, ADE awareness, and healthcare accessibility, paving the way for further exploration in personalized healthcare.

Advancements in language foundation models have primarily fueled the recent surge in artificial intelligence. In contrast, generative learning of non-textual modalities, especially videos, significantly trails behind language modeling. This thesis chronicles our endeavor to build multi-task models for generating videos and other modalities under diverse conditions, as well as for understanding and compression applications. Given the high dimensionality of visual data, we pursue concise and accurate latent representations. Our video-native spatial-temporal tokenizers preserve high fidelity. We unveil a novel approach to mapping bidirectionally between visual observation and interpretable lexical terms. Furthermore, our scalable visual token representation proves beneficial across generation, compression, and understanding tasks. This achievement marks the first instances of language models surpassing diffusion models in visual synthesis and a video tokenizer outperforming industry-standard codecs. Within these multi-modal latent spaces, we study the design of multi-task generative models. Our masked multi-task transformer excels at the quality, efficiency, and flexibility of video generation. We enable a frozen language model, trained solely on text, to generate visual content. Finally, we build a scalable generative multi-modal transformer trained from scratch, enabling the generation of videos containing high-fidelity motion with the corresponding audio given diverse conditions. Throughout the course, we have shown the effectiveness of integrating multiple tasks, crafting high-fidelity latent representation, and generating multiple modalities. This work suggests intriguing potential for future exploration in generating non-textual data and enabling real-time, interactive experiences across various media forms.

We study whether transformers can learn to implicitly reason over parametric knowledge, a skill that even the most capable language models struggle with. Focusing on two representative reasoning types, composition and comparison, we consistently find that transformers can learn implicit reasoning, but only through grokking, i.e., extended training far beyond overfitting. The levels of generalization also vary across reasoning types: when faced with out-of-distribution examples, transformers fail to systematically generalize for composition but succeed for comparison. We delve into the model's internals throughout training, conducting analytical experiments that reveal: 1) the mechanism behind grokking, such as the formation of the generalizing circuit and its relation to the relative efficiency of generalizing and memorizing circuits, and 2) the connection between systematicity and the configuration of the generalizing circuit. Our findings guide data and training setup to better induce implicit reasoning and suggest potential improvements to the transformer architecture, such as encouraging cross-layer knowledge sharing. Furthermore, we demonstrate that for a challenging reasoning task with a large search space, GPT-4-Turbo and Gemini-1.5-Pro

Large language models (LLMs) have been increasingly employed for (interactive) decision-making, via the development of LLM-based autonomous agents. Despite their emerging successes, the performance of LLM agents in decision-making has not been fully investigated through quantitative metrics, especially in the multi-agent setting when they interact with each other, a typical scenario in real-world LLM-agent applications. To better understand the limits of LLM agents in these interactive environments, we propose to study their interactions in benchmark decision-making settings in online learning and game theory, through the performance metric of \emph{regret}. We first empirically study the {no-regret} behaviors of LLMs in canonical (non-stationary) online learning problems, as well as the emergence of equilibria when LLM agents interact through playing repeated games. We then provide some theoretical insights into the no-regret behaviors of LLM agents, under certain assumptions on the supervised pre-training and the rationality model of human decision-makers who generate the data. Notably, we also identify (simple) cases where advanced LLMs such as GPT-4 fail to be no-regret. To promote the no-regret behaviors, we propose a novel \emph{unsupervised} training loss of \emph{regret-loss}, which, in contrast to the supervised pre-training loss, does not require the labels of (optimal) actions. We then establish the statistical guarantee of generalization bound for regret-loss minimization, followed by the optimization guarantee that minimizing such a loss may automatically lead to known no-regret learning algorithms. Our further experiments demonstrate the effectiveness of our regret-loss, especially in addressing the above ``regrettable'' cases.

Large Language Models (LLMs) demonstrate remarkable potential across various domains; however, they exhibit a significant performance gap in Information Extraction (IE). Note that high-quality instruction data is the vital key for enhancing the specific capabilities of LLMs, while current IE datasets tend to be small in scale, fragmented, and lack standardized schema. To this end, we introduce IEPile, a comprehensive bilingual (English and Chinese) IE instruction corpus, which contains approximately 0.32B tokens. We construct IEPile by collecting and cleaning 33 existing IE datasets, and introduce schema-based instruction generation to unearth a large-scale corpus. Experimentally, IEPile enhance the performance of LLMs for IE, with notable improvements in zero-shot generalization. We open-source the resource and pre-trained models, hoping to provide valuable support to the NLP community.

We employ Large language models (LLMs) such as GPT-fine-tuning on the LLaMa-2, Mixtral 8 7B, 4 (OpenAI, 2023), BLOOM (Le Scao et al, Gemma, and conduct a comprehensive evaluation 2023), LLaMa-2 (Touvron et al, 2023), Mistral of Vietnamese LLMs across various scenarios and (Jiang et al., 2023), Mixtral (Jiang et al., 2024), settings. Throughout the thorough evaluation process, Gemma (Team et al., 2024) have made significant we observe the following: (i) larger language contributions to the field of natural language processing models exhibit unseen capabilities compared to (NLP). Despite their advancements, a gap smaller counterparts; (ii) larger language models remains in their specialization for many languages, tend to manifest more biases, produce uncalibrated including Vietnamese. This paper addresses the results, and are more susceptible to the influence development and evaluation of Vietnamese-centric of input prompts; (iii) the quality of training or LLMs. Vietnam, with a population surpassing 100 fine-tuning datasets is the key for unlocking LLM million, ranks as the 16th most populous country performance. Our key contributions include: globally.

We survey the large language model (LLM) serving area to understand the intricate dynamics between cost-efficiency and accuracy, which is magnified by the growing need for longer contextual understanding when deploying models at a massive scale. Our findings reveal that works in this space optimize along three distinct but conflicting goals: improving serving context length (C), improving serving accuracy (A), and improving serving performance (P). Drawing inspiration from the CAP theorem in databases, we propose a CAP principle for LLM serving, which suggests that any optimization can improve at most two of these three goals simultaneously. Our survey categorizes existing works within this framework. We find the definition and continuity of user-perceived measurement metrics are crucial in determining whether a goal has been met, akin to prior CAP databases in the wild. We recognize the CAP principle for LLM serving as a guiding principle, rather than a formal theorem, to inform designers of the inherent and dynamic trade-offs in serving models. As serving accuracy and performance have been extensively studied, this survey focuses on works that extend serving context length and address the resulting challenges.

We give a model-based agent that builds a Python program representing its knowledge of the world based on its interactions with the environment. The world model tries to explain its interactions, while also being optimistic about what reward it can achieve. We define this optimism as a logical constraint between a program and a planner. We study our agent on gridworlds, and on task planning, finding our approach is more sample-efficient compared to deep RL, more compute-efficient compared to ReAct-style agents, and that it can transfer its knowledge across environments by editing its code.

With the rapid scaling of large language models (LLMs), serving numerous low-rank adaptations (LoRAs) concurrently has become increasingly impractical, leading to unaffordable costs and necessitating more parameter-efficient finetuning methods. In this work, we introduce Partially Rotation-enhanced Low-Rank Adaptation (PRoLoRA), an intra-layer sharing mechanism comprising four essential components: broadcast reduction, rotation enhancement, partially-sharing refinement, and rectified initialization strategy. As a superset of LoRA, PRoLoRA retains its advantages, and effectively circumvent the drawbacks of peer parameter-sharing methods with superior model capacity, practical feasibility, and broad applicability. Empirical experiments demonstrate the remarkably higher parameter efficiency of PRoLoRA in both specific parameter budget and performance target scenarios, and its scalability to larger LLMs. Notably, with one time less trainable parameters, PRoLoRA still outperforms LoRA on multiple instruction tuning datasets. Subsequently, an ablation study is conducted to validate the necessity of individual components and highlight the superiority of PRoLoRA over three potential variants. Hopefully, the conspicuously higher parameter efficiency can establish PRoLoRA as a resource-friendly alternative to LoRA.