Effective mental health support is crucial for alleviating psychological distress. While large language model (LLM)-based assistants have shown promise in mental health interventions, existing research often defines "effective" support primarily in terms of empathetic acknowledgments, overlooking other essential dimensions such as informational guidance, community validation, and tangible coping strategies. To address this limitation and better understand what constitutes effective support, we introduce RedditESS, a novel real-world dataset derived from Reddit posts, including supportive comments and original posters' follow-up responses. Grounded in established social science theories, we develop an ensemble labeling mechanism to annotate supportive comments as effective or not and perform qualitative assessments to ensure the reliability of the annotations. Additionally, we demonstrate the practical utility of RedditESS by using it to guide LLM alignment toward generating more context-sensitive and genuinely helpful supportive responses. By broadening the understanding of effective support, our study paves the way for advanced AI-driven mental health interventions.

Electronic Health Records (EHRs) often lack explicit links between medications and diagnoses, making clinical decision-making and research more difficult. Even when links exist, diagnosis lists may be incomplete, especially during early patient visits. Discharge summaries tend to provide more complete information, which can help infer accurate diagnoses, especially with the help of large language models (LLMs). This study investigates whether LLMs can predict implicitly mentioned diagnoses from clinical notes and link them to corresponding medications. We address two research questions: (1) Does majority voting across diverse LLM configurations outperform the best single configuration in diagnosis prediction? (2) How sensitive is majority voting accuracy to LLM hyperparameters such as temperature, top-p, and summary length? To evaluate, we created a new dataset of 240 expert-annotated medication-diagnosis pairs from 20 MIMIC-IV notes. Using GPT-3.5 Turbo, we ran 18 prompting configurations across short and long summary lengths, generating 8568 test cases. Results show that majority voting achieved 75 percent accuracy, outperforming the best single configuration at 66 percent. No single hyperparameter setting dominated, but combining deterministic, balanced, and exploratory strategies improved performance. Shorter summaries generally led to higher accuracy.In conclusion, ensemble-style majority voting with diverse LLM configurations improves diagnosis prediction in EHRs and offers a promising method to link medications and diagnoses in clinical texts.

Graph Neural Networks (GNNs), as the dominant paradigm for graph-structured learning, have long faced dual challenges of exponentially escalating computational complexity and inadequate cross-scenario generalization capability. With the rapid advancement of multimodal learning, Vision-Language Models (VLMs) have demonstrated exceptional cross-modal relational reasoning capabilities and generalization capacities, thereby opening up novel pathways for overcoming the inherent limitations of conventional graph learning paradigms. However, current research predominantly concentrates on investigating the single-graph reasoning capabilities of VLMs, which fundamentally fails to address the critical requirement for coordinated reasoning across multiple heterogeneous graph data in real-world application scenarios. To address these limitations, we propose the first multi-graph joint reasoning benchmark for VLMs. Our benchmark encompasses four graph categories: knowledge graphs, flowcharts, mind maps, and route maps,with each graph group accompanied by three progressively challenging instruction-response pairs. Leveraging this benchmark, we conducted comprehensive capability assessments of state-of-the-art VLMs and performed fine-tuning on open-source models. This study not only addresses the underexplored evaluation gap in multi-graph reasoning for VLMs but also empirically validates their generalization superiority in graph-structured learning.

We investigate the effectiveness of fine-tuning large language models (LLMs) on small medical datasets for text classification and named entity recognition tasks. Using a German cardiology report dataset and the i2b2 Smoking Challenge dataset, we demonstrate that fine-tuning small LLMs locally on limited training data can improve performance achieving comparable results to larger models. Our experiments show that fine-tuning improves performance on both tasks, with notable gains observed with as few as 200-300 training examples. Overall, the study highlights the potential of task-specific fine-tuning of LLMs for automating clinical workflows and efficiently extracting structured data from unstructured medical text.

Large language models accumulate vast knowledge during pre-training, yet the dynamics governing this acquisition remain poorly understood. This work investigates the learning dynamics of language models on a synthetic factual recall task, uncovering three key findings: First, language models learn in three phases, exhibiting a performance plateau before acquiring precise factual knowledge. Mechanistically, this plateau coincides with the formation of attention-based circuits that support recall. Second, the training data distribution significantly impacts learning dynamics, as imbalanced distributions lead to shorter plateaus. Finally, hallucinations emerge simultaneously with knowledge, and integrating new knowledge into the model through fine-tuning is challenging, as it quickly corrupts its existing parametric memories. Our results emphasize the importance of data distribution in knowledge acquisition and suggest novel data scheduling strategies to accelerate neural network training.

Retrieval-augmented generation (RAG) systems enhance large language models by incorporating external knowledge, addressing issues like outdated internal knowledge and hallucination. However, their reliance on external knowledge bases makes them vulnerable to corpus poisoning attacks, where adversarial passages can be injected to manipulate retrieval results. Existing methods for crafting such passages, such as random token replacement or training inversion models, are often slow and computationally expensive, requiring either access to retriever's gradients or large computational resources. To address these limitations, we propose Dynamic Importance-Guided Genetic Algorithm (DIGA), an efficient black-box method that leverages two key properties of retrievers: insensitivity to token order and bias towards influential tokens. By focusing on these characteristics, DIGA dynamically adjusts its genetic operations to generate effective adversarial passages with significantly reduced time and memory usage. Our experimental evaluation shows that DIGA achieves superior efficiency and scalability compared to existing methods, while maintaining comparable or better attack success rates across multiple datasets.

M ETHODS A. Multi-Agent Debate Framework We propose a multi-agent debate framework for phishing email detection, composed of three components: two debater agents, a pre-defined and scripted debate procedure, and a judge agent. The debater agents consist of two LLM-based instances, which may be instantiated from the same or different models. The first agent is prompted to argue that the given email is a phishing attempt, while the second agent is prompted to respond to the first agent's output by countering those claims and arguing for the email's legitimacy. The two agents then engage in another round to make sure that the arguments are well-formulated while maintaining computational efficiency. The debate procedure is pre-defined and scripted to generate template prompts for each email in the dataset: 1) Round One: Carefully analyze the following email and argue why it is likely to be a phishing attempt (Agent 1) Carefully analyze the following email and argue why it is likely to be legitimate and not a phishing attempt (Agent 2) 2) Round Two: Given your opponent's rebuttal, reinforce your position that the following email is a phishing attempt (Agent 1) Given your opponent's rebuttal, reinforce your position that the following email is not a phishing attempt (Agent 2) Arguments made by the two agents are logged for subsequent judge evaluation.

Artificial Intelligence (AI) has been advancing rapidly and with the advent of large language models (LLMs) in late 2022, numerous opportunities have emerged for adopting this technology across various domains, including medicine. These innovations hold immense potential to revolutionize and modernize medical education. Our research project leverages large language models to enhance medical education and address workflow challenges through the development of MediTools - AI Medical Education. This prototype application focuses on developing interactive tools that simulate real-life clinical scenarios, provide access to medical literature, and keep users updated with the latest medical news. Our first tool is a dermatology case simulation tool that uses real patient images depicting various dermatological conditions and enables interaction with LLMs acting as virtual patients. This platform allows users to practice their diagnostic skills and enhance their clinical decision-making abilities. The application also features two additional tools: an AI-enhanced PubMed tool for engaging with LLMs to gain deeper insights into research papers, and a Google News tool that offers LLM generated summaries of articles for various medical specialties. A comprehensive survey has been conducted among medical professionals and students to gather initial feedback on the effectiveness and user satisfaction of MediTools, providing insights for further development and refinement of the application. This research demonstrates the potential of AI-driven tools in transforming and revolutionizing medical education, offering a scalable and interactive platform for continuous learning and skill development.

The era of intelligent agents is upon us, driven by revolutionary advancements in large language models. Large Language Model (LLM) agents, with goal-driven behaviors and dynamic adaptation capabilities, potentially represent a critical pathway toward artificial general intelligence. This survey systematically deconstructs LLM agent systems through a methodology-centered taxonomy, linking architectural foundations, collaboration mechanisms, and evolutionary pathways. We unify fragmented research threads by revealing fundamental connections between agent design principles and their emergent behaviors in complex environments. Our work provides a unified architectural perspective, examining how agents are constructed, how they collaborate, and how they evolve over time, while also addressing evaluation methodologies, tool applications, practical challenges, and diverse application domains. By surveying the latest developments in this rapidly evolving field, we offer researchers a structured taxonomy for understanding LLM agents and identify promising directions for future research. The collection is available at https://github.com/luo-junyu/Awesome-Agent-Papers.

Quantitative investment (quant) is an emerging, technology-driven approach in asset management, increasingy shaped by advancements in artificial intelligence. Recent advances in deep learning and large language models (LLMs) for quant finance have improved predictive modeling and enabled agent-based automation, suggesting a potential paradigm shift in this field. In this survey, taking alpha strategy as a representative example, we explore how AI contributes to the quantitative investment pipeline. We first examine the early stage of quant research, centered on human-crafted features and traditional statistical models with an established alpha pipeline. We then discuss the rise of deep learning, which enabled scalable modeling across the entire pipeline from data processing to order execution. Building on this, we highlight the emerging role of LLMs in extending AI beyond prediction, empowering autonomous agents to process unstructured data, generate alphas, and support self-iterative workflows.