Large Language Model
Quantifying CBRN Risk in Frontier Models
Kumar, Divyanshu, Birur, Nitin Aravind, Baswa, Tanay, Agarwal, Sahil, Harshangi, Prashanth
Frontier Large Language Models (LLMs) pose unprecedented dual-use risks through the potential proliferation of chemical, biological, radiological, and nuclear (CBRN) weapons knowledge. We present the first comprehensive evaluation of 10 leading commercial LLMs against both a novel 200-prompt CBRN dataset and a 180-prompt subset of the FORTRESS benchmark, using a rigorous three-tier attack methodology. Our findings expose critical safety vulnerabilities: Deep Inception attacks achieve 86.0\% success versus 33.8\% for direct requests, demonstrating superficial filtering mechanisms; Model safety performance varies dramatically from 2\% (claude-opus-4) to 96\% (mistral-small-latest) attack success rates; and eight models exceed 70\% vulnerability when asked to enhance dangerous material properties. We identify fundamental brittleness in current safety alignment, where simple prompt engineering techniques bypass safeguards for dangerous CBRN information. These results challenge industry safety claims and highlight urgent needs for standardized evaluation frameworks, transparent safety metrics, and more robust alignment techniques to mitigate catastrophic misuse risks while preserving beneficial capabilities.
Large Language Models Meet Text-Attributed Graphs: A Survey of Integration Frameworks and Applications
Su, Guangxin, Wang, Hanchen, Wang, Jianwei, Zhang, Wenjie, Zhang, Ying, Pei, Jian
Large Language Models (LLMs) have achieved remarkable success in natural language processing through strong semantic understanding and generation. However, their black-box nature limits structured and multi-hop reasoning. In contrast, Text-Attributed Graphs (TAGs) provide explicit relational structures enriched with textual context, yet often lack semantic depth. Recent research shows that combining LLMs and TAGs yields complementary benefits: enhancing TAG representation learning and improving the reasoning and interpretability of LLMs. This survey provides the first systematic review of LLM--TAG integration from an orchestration perspective. We introduce a novel taxonomy covering two fundamental directions: LLM for TAG, where LLMs enrich graph-based tasks, and TAG for LLM, where structured graphs improve LLM reasoning. We categorize orchestration strategies into sequential, parallel, and multi-module frameworks, and discuss advances in TAG-specific pretraining, prompting, and parameter-efficient fine-tuning. Beyond methodology, we summarize empirical insights, curate available datasets, and highlight diverse applications across recommendation systems, biomedical analysis, and knowledge-intensive question answering. Finally, we outline open challenges and promising research directions, aiming to guide future work at the intersection of language and graph learning.
MedAlign: A Synergistic Framework of Multimodal Preference Optimization and Federated Meta-Cognitive Reasoning
Chen, Siyong, Wen, Jinbo, Kang, Jiawen, Huang, Tenghui, Huang, Xumin, Su, Yuanjia, Pan, Hudan, Zhong, Zishao, Niyato, Dusit, Xie, Shengli, Kim, Dong In
Abstract--Recently, large models have shown significant potential for smart healthcare. However, the deployment of Large Vision-Language Models (L VLMs) for clinical services is currently hindered by three critical challenges: a tendency to hallucinate answers not grounded in visual evidence, the inefficiency of fixed-depth reasoning, and the difficulty of multi-institutional collaboration. T o address these challenges, in this paper, we develop MedAlign, a novel framework to ensure visually accurate L VLM responses for Medical Visual Question Answering (Med-VQA). Specifically, we first propose a mul-timodal Direct Preference Optimization (mDPO) objective to explicitly align preference learning with visual context. T o achieve adaptive reasoning and facilitate multi-institutional collaboration, we propose a federated governance mechanism, where the selected expert, fine-tuned on clinical datasets based on mDPO, locally performs iterative Chain-of-Thought (CoT) reasoning via the local meta-cognitive uncertainty estimator . Extensive experiments on three representative Med-VQA datasets demonstrate that MedAlign achieves state-of-the-art performance, outperforming strong retrieval-augmented baselines by up to 11.85% in F1-score, and simultaneously reducing the average reasoning length by 51.60% compared with fixed-depth CoT approaches. Su, and S. Xie are with the School of Automation, Guangdong University of Technology, Guangzhou, China (e-mails: 3122000875@mail2.gdut.edu.cn, J. Wen is with the College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, China (e-mail: jinbo1608@nuaa.edu.cn). H. Pan and Z. Zhong are with State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China, and Chinese Medicine Guangdong Laboratory, Zhuhai, China (e-mails: hdpan@gzucm.edu.cn,
Designing and Evaluating Hint Generation Systems for Science Education
Jangra, Anubhav, Muresan, Smaranda
Large language models are influencing the education landscape, with students relying on them in their learning process. Often implemented using general-purpose models, these systems are likely to give away the answers, which could hinder conceptual understanding and critical thinking. We study the role of automatic hint generation as a pedagogical strategy to promote active engagement with the learning content, while guiding learners toward the answers. Focusing on scientific topics at the secondary education level, we explore the potential of large language models to generate chains of hints that scaffold learners without revealing answers. We compare two distinct hinting strategies: static hints, pre-generated for each problem, and dynamic hints, adapted to learners' progress. Through a quantitative study with 41 participants, we uncover different preferences among learners with respect to hinting strategies, and identify the limitations of automatic evaluation metrics to capture them. Our findings highlight key design considerations for future research on hint generation and intelligent tutoring systems that seek to develop learner-centered educational technologies.
ZING-3D: Zero-shot Incremental 3D Scene Graphs via Vision-Language Models
Understanding and reasoning about complex 3D environments requires structured scene representations that capture not only objects but also their semantic and spatial relationships. While recent works on 3D scene graph generation have leveraged pretrained VLMs without task-specific fine-tuning, they are largely confined to single-view settings, fail to support incremental updates as new observations arrive and lack explicit geometric grounding in 3D space, all of which are essential for embodied scenarios. In this paper, we propose, ZING-3D, a framework that leverages the vast knowledge of pretrained foundation models to enable open-vocabulary recognition and generate a rich semantic representation of the scene in a zero-shot manner while also enabling incremental updates and geometric grounding in 3D space, making it suitable for downstream robotics applications. Our approach leverages VLM reasoning to generate a rich 2D scene graph, which is grounded in 3D using depth information. Nodes represent open-vocabulary objects with features, 3D locations, and semantic context, while edges capture spatial and semantic relations with inter-object distances. Our experiments on scenes from the Replica and HM3D dataset show that ZING-3D is effective at capturing spatial and relational knowledge without the need of task-specific training.
Bridging Language Gaps with Adaptive RAG: Improving Indonesian Language Question Answering
Christian, William, Adamlu, Daniel, Yu, Adrian, Suhartono, Derwin
Abstract--Question Answering (QA) has seen significant improvements with the advancement of machine learning models, further studies enhanced this question answering system by retrieving external information, called Retrieval-Augmented Generation (RAG) to produce more accurate and informative answers. However, these state-of-the-art-performance is predominantly in English language. T o address this gap we made an effort of bridging language gaps by incorporating Adaptive RAG system to Indonesian language. Adaptive RAG system integrates a classifier whose task is to distinguish the question complexity, which in turn determines the strategy for answering the question. T o overcome the limited availability of Indonesian language dataset, our study employs machine translation as data augmentation approach. Experiments show reliable question complexity classifier; however, we observed significant inconsistencies in multi-retrieval answering strategy which negatively impacted the overall evaluation when this strategy was applied. Recent Large Language Models (LLMs) have shown incredible performance for a lot of Natural Language tasks. However, despite the advancement of LLMs in all tasks in natural language processing, they still have problems answering questions that require a knowledge-intensive background, often resulting in hallucination answers [7]. LLMs often provide accurate answers when entities mentioned in the question are present in their training data. Furthermore, the performance of the models has a significant correlation with the entity popularity; less popular entities are often not answered accurately by LLMs [8]. Updating the LLM's knowledge frequently is not a good solution since the training of LLM with billions or even trillions of data from all over the internet takes too much time. In contrast, recent studies have demonstrated that augmenting non-parametric knowledge (information not contained in the model's training data) to the question-answering method commonly referred to as Retrieval Augmented Generation (RAG) [9], even smaller models outperform larger models in terms of parameters [10].
The Virtues of Brevity: Avoid Overthinking in Parallel Test-Time Reasoning
Dinardi, Raul Cavalcante, Yamamoto, Bruno, Costa, Anna Helena Reali, Jordao, Artur
Reasoning models represent a significant advance in LLM capabilities, particularly for complex reasoning tasks such as mathematics and coding. Previous studies confirm that parallel test-time compute-sampling multiple solutions and selecting the best one-can further enhance the predictive performance of LLMs. However, strategies in this area often require complex scoring, thus increasing computational cost and complexity. In this work, we demonstrate that the simple and counterintuitive heuristic of selecting the shortest solution is highly effective. We posit that the observed effectiveness stems from models operating in two distinct regimes: a concise, confident conventional regime and a verbose overthinking regime characterized by uncertainty, and we show evidence of a critical point where the overthinking regime begins to be significant. By selecting the shortest answer, the heuristic preferentially samples from the conventional regime. We confirm that this approach is competitive with more complex methods such as self-consistency across two challenging benchmarks while significantly reducing computational overhead. The shortest-answer heuristic provides a Pareto improvement over self-consistency and applies even to tasks where output equality is not well defined.
Reasoning's Razor: Reasoning Improves Accuracy but Can Hurt Recall at Critical Operating Points in Safety and Hallucination Detection
Chegini, Atoosa, Kazemi, Hamid, Souza, Garrett, Safi, Maria, Song, Yang, Bengio, Samy, Williamson, Sinead, Farajtabar, Mehrdad
In precision-sensitive classification tasks, false positives carry severe operational consequences. For example, when a text safety classifier incorrectly flags 10% of benign user queries as unsafe, it blocks legitimate queries from being processed, degrading the experience for millions of users and potentially driving them away from the service. Similarly, in hallucination detection within Retrieval-Augmented Generation (RAG) pipelines, when factually correct responses are incorrectly flagged as hallucinated, the system triggers regeneration or self-correction mechanisms, adding unnecessary computational overhead and latency that frustrates users waiting for responses. These deployment realities demand classifiers that operate at extremely low false positive rates--often below 1%--while maintaining acceptable recall. Large language models are increasingly deployed for such precision-critical classification tasks through specialized safety guardrails like Llama Guard (Inan et al., 2023) and ShieldGemma (Zeng et al., 2024), as well as hallucination detection systems (Huang et al., 2025). Recently, reasoning-augmented approaches have emerged as a promising direction: GuardReasoner (Liu et al., 2025) incorporates chain-of-thought reasoning for safety classification, while Lynx (Ravi et al., 2024) leverages reasoning for hallucination detection in RAG
Customizing Open Source LLMs for Quantitative Medication Attribute Extraction across Heterogeneous EHR Systems
Fei, Zhe, Turali, Mehmet Yigit, Rajesh, Shreyas, Dai, Xinyang, Pham, Huyen, Holur, Pavan, Zhu, Yuhui, Mooney, Larissa, Hser, Yih-Ing, Roychowdhury, Vwani
Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across differently formatted fields and freetext notes. We present a practical framework that customizes open source large language models (LLMs), including Llama, Qwen, Gemma, and MedGemma, to extract a unified set of MOUD prescription attributes (prescription date, drug name, duration, total quantity, daily quantity, and refills) from heterogeneous, site specific data and compute a standardized metric of medication coverage, \emph{MOUD days}, per patient. Our pipeline processes records directly in a fixed JSON schema, followed by lightweight normalization and cross-field consistency checks. We evaluate the system on prescription level EHR data from five clinics in a national OUD study (25{,}605 records from 1{,}257 patients), using a previously annotated benchmark of 10{,}369 records (776 patients) as the ground truth. Performance is reported as coverage (share of records with a valid, matchable output) and record-level exact-match accuracy. Larger models perform best overall: Qwen2.5-32B achieves \textbf{93.4\%} coverage with \textbf{93.0\%} exact-match accuracy across clinics, and MedGemma-27B attains \textbf{93.1\%}/\textbf{92.2\%}. A brief error review highlights three common issues and fixes: imputing missing dosage fields using within-drug norms, handling monthly/weekly injectables (e.g., Vivitrol) by setting duration from the documented schedule, and adding unit checks to prevent mass units (e.g., ``250 g'') from being misread as daily counts. By removing brittle, site-specific ETL and supporting local, privacy-preserving deployment, this approach enables consistent cross-site analyses of MOUD exposure, adherence, and retention in real-world settings.
Race and Gender in LLM-Generated Personas: A Large-Scale Audit of 41 Occupations
van der Linden, Ilona, Kumar, Sahana, Dixit, Arnav, Sudan, Aadi, Danda, Smruthi, Anastasiu, David C., Lukoff, Kai
Generative AI tools are increasingly used to create portrayals of people in occupations, raising concerns about how race and gender are represented. We conducted a large-scale audit of over 1.5 million occupational personas across 41 U.S. occupations, generated by four large language models with different AI safety commitments and countries of origin (U.S., China, France). Compared with Bureau of Labor Statistics data, we find two recurring patterns: systematic shifts, where some groups are consistently under- or overrepresented, and stereotype exaggeration, where existing demographic skews are amplified. On average, White (--31pp) and Black (--9pp) workers are underrepresented, while Hispanic (+17pp) and Asian (+12pp) workers are overrepresented. These distortions can be extreme: for example, across all four models, Housekeepers are portrayed as nearly 100\% Hispanic, while Black workers are erased from many occupations. For HCI, these findings show provider choice materially changes who is visible, motivating model-specific audits and accountable design practices.