Feed-forward networks of localized (e.g., Gaussian) units are an interesting alternative to the more frequently used networks of global (e.g., sigmoidal) units. It has been shown that with localized units one hidden layer suffices in principle to approximate any continuous function, whereas with sigmoidal units two layers are necessary. In the following we are considering radial basis function networks similar to those proposed by Moody & Darken (1989) or Poggio & Girosi (1990). Such networks consist of one layer L of Gaussian units.

We show how an "Elman" network architecture, constructed from recurrently connected oscillatory associative memory network modules, can employ selective "attentional" control of synchronization to direct the flow of communication and computation within the architecture to solve a grammatical inference problem. Previously we have shown how the discrete time "Elman" network algorithm can be implemented in a network completely described by continuous ordinary differential equations. The time steps (machine cycles) of the system are implemented by rhythmic variation (clocking) of a bifurcation parameter. In this architecture, oscillation amplitude codes the information content or activity of a module (unit), whereas phase and frequency are used to "softwire" the network. Only synchronized modules communicate by exchanging amplitude information; the activity of non-resonating modules contributes incoherent crosstalk noise. Attentional control is modeled as a special subset of the hidden modules with ouputs which affect the resonant frequencies of other hidden modules. They control synchrony among the other modules and direct the flow of computation (attention) to effect transitions between two subgraphs of a thirteen state automaton which the system emulates to generate a Reber grammar. The internal crosstalk noise is used to drive the required random transitions of the automaton.

Bumptrees are geometric data structures introduced by Omohundro (1991) to provide efficient access to a collection of functions on a Euclidean space of interest. We describe a modified bumptree structure that has been employed as a neural network classifier, and compare its performance on several classification tasks against that of radial basis function networks and the standard mutIi-Iayer perceptron. 1 INTRODUCTION A number of neural network studies have demonstrated the utility of the multi-layer perceptron (MLP) and shown it to be a highly effective paradigm. Studies have also shown, however, that the MLP is not without its problems, in particular it requires an extensive training time, is susceptible to local minima problems and its perfonnance is dependent upon its internal network architecture. In an attempt to improve upon the generalisation performance and computational efficiency a number of studies have been undertaken principally concerned with investigating the parametrisation of the MLP. It is well known, for example, that the generalisation performance of the MLP is affected by the number of hidden units in the network, which have to be determined empirically since theory provides no guidance.

We propose a method for improving the performance of any network designed to predict the next value of a time series. Vve advocate analyzing the deviations of the network's predictions from the data in the training set. This can be carried out by a secondary network trained on the time series of these residuals. The combined system of the two networks is viewed as the new predictor. We demonstrate the simplicity and success of this method, by applying it to the sunspots data. The small corrections of the secondary network can be regarded as resulting from a Taylor expansion of a complex network which includes the combined system.

The task of drug activity prediction is to predict the activity of proposed drug compounds by learning from the observed activity of previously-synthesized drug compounds. Accurate drug activity prediction can save substantial time and money by focusing the efforts of chemists and biologists on the synthesis and testing of compounds whose predicted activity is high. If the requirements for highly active binding can be displayed in three dimensions, chemists can work from such displays to design new compounds having high predicted activity. Drug molecules usually act by binding to localized sites on large receptor molecules or large enyzme molecules. One reasonable way to represent drug molecules is to capture the location of their surface in the (fixed) frame of reference of the (hypothesized) binding site.

In this paper, it is shown that the conventional back-propagation (BPP) algorithm for neural network regression is robust to leverages (data with:n corrupted), but not to outliers (data with y corrupted). A robust model is to model the error as a mixture of normal distribution. The influence function for this mixture model is calculated and the condition for the model to be robust to outliers is given. EM algorithm [5] is used to estimate the parameter. The usefulness of model selection criteria is also discussed.

Four versions of a k-nearest neighbor algorithm with locally adaptive k are introduced and compared to the basic k-nearest neighbor algorithm (kNN). Locally adaptive kNN algorithms choose the value of k that should be used to classify a query by consulting the results of cross-validation computations in the local neighborhood of the query. Local kNN methods are shown to perform similar to kNN in experiments with twelve commonly used data sets. Encouraging results in three constructed tasks show that local methods can significantly outperform kNN in specific applications. Local methods can be recommended for online learning and for applications where different regions of the input space are covered by patterns solving different sub-tasks.

An approach is presented to learning high dimensional functions in the case where the learning algorithm can affect the generation of new data. A local modeling algorithm, locally weighted regression, is used to represent the learned function. Architectural parameters of the approach, such as distance metrics, are also localized and become a function of the query point instead of being global. Statistical tests are given for when a local model is good enough and sampling should be moved to a new area. Our methods explicitly deal with the case where prediction accuracy requirements exist during exploration: By gradually shifting a "center of exploration" and controlling the speed of the shift with local prediction accuracy, a goal-directed exploration of state space takes place along the fringes of the current data support until the task goal is achieved.

Dimension reduction provides compact representations for storage, transmission, and classification. Dimension reduction algorithms operate by identifying and eliminating statistical redundancies in the data. The optimal linear technique for dimension reduction is principal component analysis (PCA).

We represent objects with n-dimensional pattern vectors and consider piecewise-linear classifiers consisting of a collection of (labeled) codebook vectors in the space of the input patterns (See Figure 1). The classification boundaries are gi ven by the voronoi tessellation of the codebook vectors. Patterns are said to belong to the class (given by the label) of the codebook vector to which they are closest.