Functional neuroimaging can measure the brain?s response to an external stimulus. It is used to perform brain mapping: identifying from these observations the brain regions involved. This problem can be cast into a linear supervised learning task where the neuroimaging data are used as predictors for the stimulus. Brain mapping is then seen as a support recovery problem. On functional MRI (fMRI) data, this problem is particularly challenging as i) the number of samples is small due to limited acquisition time and ii) the variables are strongly correlated. We propose to overcome these difficulties using sparse regression models over new variables obtained by clustering of the original variables. The use of randomization techniques, e.g. bootstrap samples, and clustering of the variables improves the recovery properties of sparse methods. We demonstrate the benefit of our approach on an extensive simulation study as well as two fMRI datasets.

In this paper we study output coding for multi-label prediction. For a multi-label output coding to be discriminative, it is important that codewords for different label vectors are significantly different from each other. In the meantime, unlike in traditional coding theory, codewords in output coding are to be predicted from the input, so it is also critical to have a predictable label encoding. To find output codes that are both discriminative and predictable, we first propose a max-margin formulation that naturally captures these two properties. We then convert it to a metric learning formulation, but with an exponentially large number of constraints as commonly encountered in structured prediction problems. Without a label structure for tractable inference, we use overgenerating (i.e., relaxation) techniques combined with the cutting plane method for optimization. In our empirical study, the proposed output coding scheme outperforms a variety of existing multi-label prediction methods for image, text and music classification.

We show how to reduce the process of predicting general order statistics (and the median in particular) to solving classification. The accompanying theoretical statement shows that the regret of the classifier bounds the regret of the quantile regression under a quantile loss. We also test this reduction empirically against existing quantile regression methods on large real-world datasets and discover that it provides state-of-the-art performance.

We demonstrate that almost all non-parametric dimensionality reduction methods can be expressed by a simple procedure: regularized loss minimization plus singular value truncation. By distinguishing the role of the loss and regularizer in such a process, we recover a factored perspective that reveals some gaps in the current literature. Beyond identifying a useful new loss for manifold unfolding, a key contribution is to derive new convex regularizers that combine distance maximization with rank reduction. These regularizers can be applied to any loss.

We consider analysis of relational data (a matrix), in which the rows correspond to subjects (e.g., people) and the columns correspond to attributes. The elements of the matrix may be a mix of real and categorical. Each subject and attribute is characterized by a latent binary feature vector, and an inferred matrix maps each row-column pair of binary feature vectors to an observed matrix element. The latent binary features of the rows are modeled via a multivariate Gaussian distribution with low-rank covariance matrix, and the Gaussian random variables are mapped to latent binary features via a probit link. The same type construction is applied jointly to the columns. The model infers latent, low-dimensional binary features associated with each row and each column, as well correlation structure between all rows and between all columns.

To date, testing interactions in high dimensions has been a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal p-values. To help alleviate these issues, we propose a permutation-based method for testing marginal interactions with a binary response. Our method searches for pairwise correlations which differ between classes. In this manuscript, we compare our method on real and simulated data to the standard approach of running many pairwise logistic models. On simulated data our method finds more significant interactions at a lower false discovery rate (especially in the presence of main effects). On real genomic data, although there is no gold standard, our method finds apparent signal and tells a believable story, while logistic regression does not. We also give asymptotic consistency results under not too restrictive assumptions.

LSTD is a popular algorithm for value function approximation. Whenever the number of features is larger than the number of samples, it must be paired with some form of regularization. In particular, L1-regularization methods tend to perform feature selection by promoting sparsity, and thus, are well-suited for high-dimensional problems. However, since LSTD is not a simple regression algorithm, but it solves a fixed--point problem, its integration with L1-regularization is not straightforward and might come with some drawbacks (e.g., the P-matrix assumption for LASSO-TD). In this paper, we introduce a novel algorithm obtained by integrating LSTD with the Dantzig Selector. We investigate the performance of the proposed algorithm and its relationship with the existing regularized approaches, and show how it addresses some of their drawbacks.

In this work, we develop a simple algorithm for semi-supervised regression. The key idea is to use the top eigenfunctions of integral operator derived from both labeled and unlabeled examples as the basis functions and learn the prediction function by a simple linear regression. We show that under appropriate assumptions about the integral operator, this approach is able to achieve an improved regression error bound better than existing bounds of supervised learning. We also verify the effectiveness of the proposed algorithm by an empirical study.

We present a novel approach to the formulation and the resolution of sparse Linear Discriminant Analysis (LDA). Our proposal, is based on penalized Optimal Scoring. It has an exact equivalence with penalized LDA, contrary to the multi-class approaches based on the regression of class indicator that have been proposed so far. Sparsity is obtained thanks to a group-Lasso penalty that selects the same features in all discriminant directions. Our experiments demonstrate that this approach generates extremely parsimonious models without compromising prediction performances. Besides prediction, the resulting sparse discriminant directions are also amenable to low-dimensional representations of data. Our algorithm is highly efficient for medium to large number of variables, and is thus particularly well suited to the analysis of gene expression data.

Multiple kernel learning algorithms are proposed to combine kernels in order to obtain a better similarity measure or to integrate feature representations coming from different data sources. Most of the previous research on such methods is focused on the computational efficiency issue. However, it is still not feasible to combine many kernels using existing Bayesian approaches due to their high time complexity. We propose a fully conjugate Bayesian formulation and derive a deterministic variational approximation, which allows us to combine hundreds or thousands of kernels very efficiently. We briefly explain how the proposed method can be extended for multiclass learning and semi-supervised learning. Experiments with large numbers of kernels on benchmark data sets show that our inference method is quite fast, requiring less than a minute. On one bioinformatics and three image recognition data sets, our method outperforms previously reported results with better generalization performance.