We study a variant of the variational autoencoder model (VAE) with a Gaussian mixture as a prior distribution, with the goal of performing unsupervised clustering through deep generative models. We observe that the known problem of over-regularisation that has been shown to arise in regular VAEs also manifests itself in our model and leads to cluster degeneracy. We show that a heuristic called minimum information constraint that has been shown to mitigate this effect in VAEs can also be applied to improve unsupervised clustering performance with our model. Furthermore we analyse the effect of this heuristic and provide an intuition of the various processes with the help of visualizations. Finally, we demonstrate the performance of our model on synthetic data, MNIST and SVHN, showing that the obtained clusters are distinct, interpretable and result in achieving competitive performance on unsupervised clustering to the state-of-the-art results.

A small fraction of individuals account for the bulk of population healthcare expenditures in the USA, Denmark and other industrialised countries.1–4 Although many high-cost patients show consecutive high-cost years, the majority experience a'cost bloom', or a surge in healthcare costs that propels them from a lower to the upper decile of population-level healthcare expenditures between consecutive years.4 Proactively identifying and managing care for high-cost patients--especially cost bloomers, who may disproportionately benefit from interventions to mitigate future high-cost years--can be an effective way to simultaneously improve quality and reduce population health costs.5–16 However, since the Centers for Medicare and Services (CMS) commissioned the Society of Actuaries to compare leading prediction tools more than 10 years ago, scant progress has been made in improving cost-prediction tools.17 Overcoming these and other challenges associated with the management and care of high-cost patients is essential to achieving a higher value healthcare system.

She is currently in the NYC Data Science Academy 12 week full time Data Science Bootcamp pr... taking place between April 11th to July 1st, 2016. This post is based on her third class project - Web Scraping, due on the 6th week of the program. Oil prices have fallen sharply since the summer of 2014. Prices bottomed in February 2016, since then they have gradually increased. While the breakeven cost is a popular topic among investors, on the consumer side gasoline prices are very cheap.

Stochastic fluctuations of molecule numbers are ubiquitous in biological systems. Important examples include gene expression and enzymatic processes in living cells. Such systems are typically modelled as chemical reaction networks whose dynamics are governed by the Chemical Master Equation. Despite its simple structure, no analytic solutions to the Chemical Master Equation are known for most systems. Moreover, stochastic simulations are computationally expensive, making systematic analysis and statistical inference a challenging task. Consequently, significant effort has been spent in recent decades on the development of efficient approximation and inference methods. This article gives an introduction to basic modelling concepts as well as an overview of state of the art methods. First, we motivate and introduce deterministic and stochastic methods for modelling chemical networks, and give an overview of simulation and exact solution methods. Next, we discuss several approximation methods, including the chemical Langevin equation, the system size expansion, moment closure approximations, time-scale separation approximations and hybrid methods. We discuss their various properties and review recent advances and remaining challenges for these methods. We present a comparison of several of these methods by means of a numerical case study and highlight some of their respective advantages and disadvantages. Finally, we discuss the problem of inference from experimental data in the Bayesian framework and review recent methods developed the literature. In summary, this review gives a self-contained introduction to modelling, approximations and inference methods for stochastic chemical kinetics.

We propose a modified expectation-maximization algorithm by introducing the concept of quantum annealing, which we call the deterministic quantum annealing expectation-maximization (DQAEM) algorithm. The expectation-maximization (EM) algorithm is an established algorithm to compute maximum likelihood estimates and applied to many practical applications. However, it is known that EM heavily depends on initial values and its estimates are sometimes trapped by local optima. To solve such a problem, quantum annealing (QA) was proposed as a novel optimization approach motivated by quantum mechanics. By employing QA, we then formulate DQAEM and present a theorem that supports its stability. Finally, we demonstrate numerical simulations to confirm its efficiency.

This particular class of algorithms has recently gained popularity due to their effectiveness in solving large-scale optimization problems in machine learning, compressed sensing, image processing, and computational statistics. Coordinate descent algorithms solve optimization problems by successively minimizing along each coordinate or coordinate hyperplane, which is ideal for parallelized and distributed computing. Avoiding detailed technicalities and proofs, this monograph gives relevant theory and examples for practitioners to effectively apply coordinate descent to modern problems in data science and engineering. To keep the primer up-to-date, we intend to publish this monograph only after no additional topics need to be added and we foresee no further major advances in the area. 1 Introduction

Inverse classification is the process of perturbing an instance in a meaningful way such that it is more likely to conform to a specific class. Historical methods that address such a problem are often framed to leverage only a single classifier, or specific set of classifiers. These works are often accompanied by naive assumptions. In this work we propose generalized inverse classification (GIC), which avoids restricting the classification model that can be used. We incorporate this formulation into a refined framework in which GIC takes place. Under this framework, GIC operates on features that are immediately actionable. Each change incurs an individual cost, either linear or non-linear. Such changes are subjected to occur within a specified level of cumulative change (budget). Furthermore, our framework incorporates the estimation of features that change as a consequence of direct actions taken (indirectly changeable features). To solve such a problem, we propose three real-valued heuristic-based methods and two sensitivity analysis-based comparison methods, each of which is evaluated on two freely available real-world datasets. Our results demonstrate the validity and benefits of our formulation, framework, and methods.

With the development of free, open-source machine learning and artificial intelligence tools like Google's TensorFlow and sci-kit learn, as well as "ML-as-a-service" products like Google's Cloud Prediction API and Microsoft's Azure Machine Learning platform, it's never been easier for companies of all sizes to harness the power of data. But machine learning is such a vast, complex field. Where do you start learning how to use it in your business? In this article, we'll survey the current landscape of machine learning algorithms and explain how they work, provide example applications, share how other companies use them, and provide further resources on learning about them. This executive overview will provide the first step in learning how to apply machine learning algorithm(s) to make your business more efficient, more effective, and more profitable.

The rules of the game called psychological science.

The portal is funded by the European FP7 project "Organic" and the University of Gent. The Fraunhofer Institute for Intelligent Analysis and Information Systems claims international patents for commercial exploits of the ESN architecture and learning principle.