Breast cancer is one of the leading causes of death among women across the globe. It is difficult to treat if detected at advanced stages, however, early detection can significantly increase chances of survival and improves lives of millions of women. Given the widespread prevalence of breast cancer, it is of utmost importance for the research community to come up with the framework for early detection, classification and diagnosis. Artificial intelligence research community in coordination with medical practitioners are developing such frameworks to automate the task of detection. With the surge in research activities coupled with availability of large datasets and enhanced computational powers, it expected that AI framework results will help even more clinicians in making correct predictions. In this article, a novel framework for classification of breast cancer using mammograms is proposed. The proposed framework combines robust features extracted from novel Convolutional Neural Network (CNN) features with handcrafted features including HOG (Histogram of Oriented Gradients) and LBP (Local Binary Pattern). The obtained results on CBIS-DDSM dataset exceed state of the art.

We study the privatization of distributed learning and optimization strategies. We focus on differential privacy schemes and study their effect on performance. We show that the popular additive random perturbation scheme degrades performance because it is not well-tuned to the graph structure. For this reason, we exploit two alternative graph-homomorphic constructions and show that they improve performance while guaranteeing privacy. Moreover, contrary to most earlier studies, the gradient of the risks is not assumed to be bounded (a condition that rarely holds in practice; e.g., quadratic risk). We avoid this condition and still devise a differentially private scheme with high probability. We examine optimization and learning scenarios and illustrate the theoretical findings through simulations.

According to the Lancet report on the global burden of disease published in October 2020, air pollution is among the five highest risk factors for global health, reducing life expectancy on average by 20 months. This paper describes a data-driven method for establishing causal relationships within and between two multivariate time series data streams derived from wearable sensors: personal exposure to airborne particulate matter of aerodynamic sizes less than 2.5um (PM2.5) gathered from the Airspeck monitor worn on the person and continuous respiratory rate (breaths per minute) measured by the Respeck monitor worn as a plaster on the chest. Results are presented for a cohort of 113 asthmatic adolescents using the PCMCI+ algorithm to learn the short-term causal relationships between lags of \pm exposure and respiratory rate. We consider causal effects up to a maximum delay of 8 hours, using data at both a 1 minute and 15 minute resolution in different experiments. For the first time a personalised exposure-response relationship between PM2.5 exposure and respiratory rate has been demonstrated to exist for short-term effects in asthmatic adolescents during their everyday lives. Our results lead to recommendations for work on specific open problems in causal discovery, to increase the feasibility of this approach for similar epidemiology studies in the future.

Sharpness-aware minimization (SAM) is a recently proposed training method that seeks to find flat minima in deep learning, resulting in state-of-the-art performance across various domains. Instead of minimizing the loss of the current weights, SAM minimizes the worst-case loss in its neighborhood in the parameter space. In this paper, we demonstrate that SAM dynamics can have convergence instability that occurs near a saddle point. Utilizing the qualitative theory of dynamical systems, we explain how SAM becomes stuck in the saddle point and then theoretically prove that the saddle point can become an attractor under SAM dynamics. Additionally, we show that this convergence instability can also occur in stochastic dynamical systems by establishing the diffusion of SAM. We prove that SAM diffusion is worse than that of vanilla gradient descent in terms of saddle point escape. Further, we demonstrate that often overlooked training tricks, momentum and batch-size, are important to mitigate the convergence instability and achieve high generalization performance. Our theoretical and empirical results are thoroughly verified through experiments on several well-known optimization problems and benchmark tasks.

Estimating the effect of a treatment on an outcome is a fundamental problem in many fields such as medicine [33, 34, 61], public policy [20] and more [2, 37]. For example, doctors might be interested in how a treatment, such as a drug, affects the recovery of patients [18], economists may be interested in how a job training program affects employment prospectives [35], and advertisers may want to model the average effect an advertisement has on sales [36]. However, individuals may react differently to the treatment of interest, and knowing only the average treatment effect in the population is insufficient. For example, a drug may have adverse effects on some individuals but not others [61], or a person's education and background may affect how much they benefit from job training [35, 50]. Measuring the extent to which different individuals react differently to treatment is known as heterogeneous treatment effect (HTE) estimation. Traditionally, HTE estimation has been done through subgroup analysis [9, 19]. However, this can lead to cherry-picking since the practitioner is the one who identifies subgroups for estimating effects. Recently, there has been more focus on data-driven estimation of heterogeneous treatment effects by letting the data identify which features are important for treatment effect estimation using machine learning techniques [28, 39, 61, 69]. A straightforward approach is to create interaction terms between all covariates and use them in a regression [6].

Learning invariant (causal) features for out-of-distribution (OOD) generalization has attracted extensive attention recently, and among the proposals invariant risk minimization (IRM) is a notable solution. In spite of its theoretical promise for linear regression, the challenges of using IRM in linear classification problems remain. By introducing the information bottleneck (IB) principle into the learning of IRM, IB-IRM approach has demonstrated its power to solve these challenges. In this paper, we further improve IB-IRM from two aspects. First, we show that the key assumption of support overlap of invariant features used in IB-IRM is strong for the guarantee of OOD generalization and it is still possible to achieve the optimal solution without this assumption. Second, we illustrate two failure modes that IB-IRM (and IRM) could fail for learning the invariant features, and to address such failures, we propose a \textit{Counterfactual Supervision-based Information Bottleneck (CSIB)} learning algorithm that provably recovers the invariant features. By requiring counterfactual inference, CSIB works even when accessing data from a single environment. Empirical experiments on several datasets verify our theoretical results.

We first adopt a human-guided machine learning framework to develop a new dataset for hyperpartisan news title detection with 2,200 manually labeled and 1.8 million machine-labeled titles that were posted from 2014 to the present by nine representative media organizations across three media bias groups - Left, Central, and Right in an active learning manner. The fine-tuned transformer-based language model achieves an overall accuracy of 0.84 and an F1 score of 0.78 on an external validation set. Next, we conduct a computational analysis to quantify the extent and dynamics of partisanship in news titles. While some aspects are as expected, our study reveals new or nuanced differences between the three media groups. We find that overall the Right media tends to use proportionally more hyperpartisan titles. Roughly around the 2016 Presidential Election, the proportions of hyperpartisan titles increased in all media bias groups where the relative increase in the proportion of hyperpartisan titles of the Left media was the most. We identify three major topics including foreign issues, political systems, and societal issues that are suggestive of hyperpartisanship in news titles using logistic regression models and the Shapley values. Through an analysis of the topic distribution, we find that societal issues gradually receive more attention from all media groups. We further apply a lexicon-based language analysis tool to the titles of each topic and quantify the linguistic distance between any pairs of the three media groups. Three distinct patterns are discovered. The Left media is linguistically more different from Central and Right in terms of foreign issues. The linguistic distance between the three media groups becomes smaller over recent years. In addition, a seasonal pattern where linguistic difference is associated with elections is observed for societal issues.

Schizophrenia (SCZ) is a brain disorder where different people experience different symptoms, such as hallucination, delusion, flat-talk, disorganized thinking, etc. In the long term, this can cause severe effects and diminish life expectancy by more than ten years. Therefore, early and accurate diagnosis of SCZ is prevalent, and modalities like structural magnetic resonance imaging (sMRI), functional MRI (fMRI), diffusion tensor imaging (DTI), and electroencephalogram (EEG) assist in witnessing the brain abnormalities of the patients. Moreover, for accurate diagnosis of SCZ, researchers have used machine learning (ML) algorithms for the past decade to distinguish the brain patterns of healthy and SCZ brains using MRI and fMRI images. This paper seeks to acquaint SCZ researchers with ML and to discuss its recent applications to the field of SCZ study. This paper comprehensively reviews state-of-the-art techniques such as ML classifiers, artificial neural network (ANN), deep learning (DL) models, methodological fundamentals, and applications with previous studies. The motivation of this paper is to benefit from finding the research gaps that may lead to the development of a new model for accurate SCZ diagnosis. The paper concludes with the research finding, followed by the future scope that directly contributes to new research directions.

The field of visual few-shot classification aims at transferring the state-of-the-art performance of deep learning visual systems onto tasks where only a very limited number of training samples are available. The main solution consists in training a feature extractor using a large and diverse dataset to be applied to the considered few-shot task. Thanks to the encoded priors in the feature extractors, classification tasks with as little as one example (or "shot'') for each class can be solved with high accuracy, even when the shots display individual features not representative of their classes. Yet, the problem becomes more complicated when some of the given shots display multiple objects. In this paper, we present a strategy which aims at detecting the presence of multiple and previously unseen objects in a given shot. This methodology is based on identifying the corners of a simplex in a high dimensional space. We introduce an optimization routine and showcase its ability to successfully detect multiple (previously unseen) objects in raw images. Then, we introduce a downstream classifier meant to exploit the presence of multiple objects to improve the performance of few-shot classification, in the case of extreme settings where only one shot is given for its class. Using standard benchmarks of the field, we show the ability of the proposed method to slightly, yet statistically significantly, improve accuracy in these settings.

Federated learning (FL) is a promising paradigm that enables collaboratively learning a shared model across massive clients while keeping the training data locally. However, for many existing FL systems, clients need to frequently exchange model parameters of large data size with the remote cloud server directly via wide-area networks (WAN), leading to significant communication overhead and long transmission time. To mitigate the communication bottleneck, we resort to the hierarchical federated learning paradigm of HiFL, which reaps the benefits of mobile edge computing and combines synchronous client-edge model aggregation and asynchronous edge-cloud model aggregation together to greatly reduce the traffic volumes of WAN transmissions. Specifically, we first analyze the convergence bound of HiFL theoretically and identify the key controllable factors for model performance improvement. We then advocate an enhanced design of HiFlash by innovatively integrating deep reinforcement learning based adaptive staleness control and heterogeneity-aware client-edge association strategy to boost the system efficiency and mitigate the staleness effect without compromising model accuracy. Extensive experiments corroborate the superior performance of HiFlash in model accuracy, communication reduction, and system efficiency.