Deep learning models have exhibited exceptional effectiveness in Computational Pathology (CPath) by tackling intricate tasks across an array of histology image analysis applications. Nevertheless, the presence of out-of-distribution data (stemming from a multitude of sources such as disparate imaging devices and diverse tissue preparation methods) can cause \emph{domain shift} (DS). DS decreases the generalization of trained models to unseen datasets with slightly different data distributions, prompting the need for innovative \emph{domain generalization} (DG) solutions. Recognizing the potential of DG methods to significantly influence diagnostic and prognostic models in cancer studies and clinical practice, we present this survey along with guidelines on achieving DG in CPath. We rigorously define various DS types, systematically review and categorize existing DG approaches and resources in CPath, and provide insights into their advantages, limitations, and applicability. We also conduct thorough benchmarking experiments with 28 cutting-edge DG algorithms to address a complex DG problem. Our findings suggest that careful experiment design and CPath-specific Stain Augmentation technique can be very effective. However, there is no one-size-fits-all solution for DG in CPath. Therefore, we establish clear guidelines for detecting and managing DS depending on different scenarios. While most of the concepts, guidelines, and recommendations are given for applications in CPath, we believe that they are applicable to most medical image analysis tasks as well.

Representing documents into high dimensional embedding space while preserving the structural similarity between document sources has been an ultimate goal for many works on text representation learning. Current embedding models, however, mainly rely on the availability of label supervision to increase the expressiveness of the resulting embeddings. In contrast, unsupervised embeddings are cheap, but they often cannot capture implicit structure in target corpus, particularly for samples that come from different distribution with the pretraining source. Our study aims to loosen up the dependency on label supervision by learning document embeddings via Sequence-to-Sequence (Seq2Seq) text generator. Specifically, we reformulate keyphrase generation task into multi-label keyword generation in community-based Question Answering (cQA). Our empirical results show that KeyGen2Vec in general is superior than multi-label keyword classifier by up to 14.7% based on Purity, Normalized Mutual Information (NMI), and F1-Score metrics. Interestingly, although in general the absolute advantage of learning embeddings through label supervision is highly positive across evaluation datasets, KeyGen2Vec is shown to be competitive with classifier that exploits topic label supervision in Yahoo! cQA with larger number of latent topic labels.

Many of the tools available for robot learning were designed for Euclidean data. However, many applications in robotics involve manifold-valued data. A common example is orientation; this can be represented as a 3-by-3 rotation matrix or a quaternion, the spaces of which are non-Euclidean manifolds. In robot learning, manifold-valued data are often handled by relating the manifold to a suitable Euclidean space, either by embedding the manifold or by projecting the data onto one or several tangent spaces. These approaches can result in poor predictive accuracy, and convoluted algorithms. In this paper, we propose an "intrinsic" approach to regression that works directly within the manifold. It involves taking a suitable probability distribution on the manifold, letting its parameter be a function of a predictor variable, such as time, then estimating that function non-parametrically via a "local likelihood" method that incorporates a kernel. We name the method kernelised likelihood estimation. The approach is conceptually simple, and generally applicable to different manifolds. We implement it with three different types of manifold-valued data that commonly appear in robotics applications. The results of these experiments show better predictive accuracy than projection-based algorithms.

Federated learning (FL) has been recognized as a rapidly growing research area, where the model is trained over massively distributed clients under the orchestration of a parameter server (PS) without sharing clients' data. This paper delves into a class of federated problems characterized by non-convex and non-smooth loss functions, that are prevalent in FL applications but challenging to handle due to their intricate non-convexity and non-smoothness nature and the conflicting requirements on communication efficiency and privacy protection. In this paper, we propose a novel federated primal-dual algorithm with bidirectional model sparsification tailored for non-convex and non-smooth FL problems, and differential privacy is applied for strong privacy guarantee. Its unique insightful properties and some privacy and convergence analyses are also presented for the FL algorithm design guidelines. Extensive experiments on real-world data are conducted to demonstrate the effectiveness of the proposed algorithm and much superior performance than some state-of-the-art FL algorithms, together with the validation of all the analytical results and properties.

The theory of Kazantzis-Kravaris/Luenberger (KKL) observer design introduces a methodology that uses a nonlinear transformation map and its left inverse to estimate the state of a nonlinear system through the introduction of a linear observer state space. Data-driven approaches using artificial neural networks have demonstrated the ability to accurately approximate these transformation maps. This paper presents a novel approach to observer design for nonlinear dynamical systems through meta-learning, a concept in machine learning that aims to optimize learning models for fast adaptation to a distribution of tasks through an improved focus on the intrinsic properties of the underlying learning problem. We introduce a framework that leverages information from measurements of the system output to design a learning-based KKL observer capable of online adaptation to a variety of system conditions and attributes. To validate the effectiveness of our approach, we present comprehensive experimental results for the estimation of nonlinear system states with varying initial conditions and internal parameters, demonstrating high accuracy, generalization capability, and robustness against noise.

Diffusion-based planning has shown promising results in long-horizon, sparse-reward tasks by training trajectory diffusion models and conditioning the sampled trajectories using auxiliary guidance functions. However, due to their nature as generative models, diffusion models are not guaranteed to generate feasible plans, resulting in failed execution and precluding planners from being useful in safety-critical applications. In this work, we propose a novel approach to refine unreliable plans generated by diffusion models by providing refining guidance to error-prone plans. To this end, we suggest a new metric named restoration gap for evaluating the quality of individual plans generated by the diffusion model. A restoration gap is estimated by a gap predictor which produces restoration gap guidance to refine a diffusion planner. We additionally present an attribution map regularizer to prevent adversarial refining guidance that could be generated from the sub-optimal gap predictor, which enables further refinement of infeasible plans. We demonstrate the effectiveness of our approach on three different benchmarks in offline control settings that require long-horizon planning. We also illustrate that our approach presents explainability by presenting the attribution maps of the gap predictor and highlighting error-prone transitions, allowing for a deeper understanding of the generated plans.

Abstract-Breast cancer (BC) significantly contributes to cancer-related mortality in women, underscoring the criticality of early detection for optimal patient outcomes. A mammography is a key tool for identifying and diagnosing breast abnormalities; however, accurately distinguishing malignant mass lesions remains challenging. To address this issue, we propose a novel deep learning approach for BC screening utilizing mammography images. Our proposed model comprises three distinct stages: data collection from established benchmark sources, image segmentation employing an Atrous Convolution-based Attentive and Adaptive Trans-Res-UNet (ACA-ATRUNet) architecture, and BC identification via an Atrous Convolution-based Attentive and Adaptive Multiscale DenseNet (ACA-AMDN) model. The hyperparameters within the ACA-ATRUNet and ACA-AMDN models are optimised using the Modified Mussel Length-based Eurasian Oystercatcher Optimization (MML-EOO) algorithm. Performance evaluation, leveraging multiple metrics, is conducted, and a comparative analysis against conventional methods is presented. Our experimental findings reveal that the proposed BC detection framework attains superior precision rates in early disease detection, demonstrating its potential to enhance mammography-based screening methodologies. Keywords: Breast Cancer; Mammograms; Atrous Convolution-based Attentive and Adaptive Trans-Res-UNet; Modified Mussel Length-based Eurasian Oystercatcher Optimization; Atrous Convolution based Attentive and Adaptive Multi-scale DenseNet 1. Introduction The most prevalent type of malignancy in women is BC. Next to cancer, it is the second leading reason of mortality in women [1]. One in every 36 female deaths is related to BC, or around 3% of all female deaths are caused by BC. In order to improve the survival rate of the patient, early BC identification is crucial [2]. Researchers are introducing increasingly accurate models for BC diagnosis into practice because of the tremendous fatality and high expense of cancer-related treatment [3, 4]. Radiotherapists use mammography as an efficient imaging method to detect and screen the presence of BC. Mammography is the primary clinical test for BC and is quite accurate in predicting BC. Breast lumps and calcifications are considered the early signs of BC, respectively.

We present a scalable combined localization infrastructure deployment and task planning algorithm for underwater assembly. Infrastructure is autonomously modified to suit the needs of manipulation tasks based on an uncertainty model on the infrastructure's positional accuracy. Our uncertainty model can be combined with the noise characteristics from multiple devices. For the task planning problem, we propose a layer-based clustering approach that completes the manipulation tasks one cluster at a time. We employ movable visual fiducial markers as infrastructure and an autonomous underwater vehicle (AUV) for manipulation tasks. The proposed task planning algorithm is computationally simple, and we implement it on AUV without any offline computation requirements. Combined hardware experiments and simulations over large datasets show that the proposed technique is scalable to large areas.

In the last years, the weakly supervised paradigm of multiple instance learning (MIL) has become very popular in many different areas. A paradigmatic example is computational pathology, where the lack of patch-level labels for whole-slide images prevents the application of supervised models. Probabilistic MIL methods based on Gaussian Processes (GPs) have obtained promising results due to their excellent uncertainty estimation capabilities. However, these are general-purpose MIL methods that do not take into account one important fact: in (histopathological) images, the labels of neighboring patches are expected to be correlated. In this work, we extend a state-of-the-art GP-based MIL method, which is called VGPMIL-PR, to exploit such correlation. To do so, we develop a novel coupling term inspired by the statistical physics Ising model. We use variational inference to estimate all the model parameters. Interestingly, the VGPMIL-PR formulation is recovered when the weight that regulates the strength of the Ising term vanishes. The performance of the proposed method is assessed in two real-world problems of prostate cancer detection. We show that our model achieves better results than other state-of-the-art probabilistic MIL methods. We also provide different visualizations and analysis to gain insights into the influence of the novel Ising term. These insights are expected to facilitate the application of the proposed model to other research areas.

In a model inversion (MI) attack, an adversary abuses access to a machine learning (ML) model to infer and reconstruct private training data. Remarkable progress has been made in the white-box and black-box setups, where the adversary has access to the complete model or the model's soft output respectively. However, there is very limited study in the most challenging but practically important setup: Label-only MI attacks, where the adversary only has access to the model's predicted label (hard label) without confidence scores nor any other model information. In this work, we propose LOKT, a novel approach for label-only MI attacks. Our idea is based on transfer of knowledge from the opaque target model to surrogate models. Subsequently, using these surrogate models, our approach can harness advanced white-box attacks. We propose knowledge transfer based on generative modelling, and introduce a new model, Target model-assisted ACGAN (T-ACGAN), for effective knowledge transfer. Our method casts the challenging label-only MI into the more tractable white-box setup. We provide analysis to support that surrogate models based on our approach serve as effective proxies for the target model for MI. Our experiments show that our method significantly outperforms existing SOTA Label-only MI attack by more than 15% across all MI benchmarks. Furthermore, our method compares favorably in terms of query budget. Our study highlights rising privacy threats for ML models even when minimal information (i.e., hard labels) is exposed. Our study highlights rising privacy threats for ML models even when minimal information (i.e., hard labels) is exposed. Our code, demo, models and reconstructed data are available at our project page: https://ngoc-nguyen-0.github.io/lokt/