Species subject to predation and environmental threats commonly exhibit variable periods of population boom and bust over long timescales. Understanding and predicting such behavior, especially given the inherent heterogeneity and stochasticity of exogenous driving factors over short timescales, is an ongoing challenge. A modeling paradigm gaining popularity in the ecological sciences for such multi-scale effects is to couple short-term continuous dynamics to long-term discrete updates. We develop a data-driven method utilizing weak-form equation learning to extract such hybrid governing equations for population dynamics and to estimate the requisite parameters using sparse intermittent measurements of the discrete and continuous variables. The method produces a set of short-term continuous dynamical system equations parametrized by long-term variables, and long-term discrete equations parametrized by short-term variables, allowing direct assessment of interdependencies between the two time scales. We demonstrate the utility of the method on a variety of ecological scenarios and provide extensive tests using models previously derived for epizootics experienced by the North American spongy moth (Lymantria dispar dispar).

Primary Immune thrombocytopenia (ITP) is a rare autoimmune disease characterised by immune-mediated destruction of peripheral blood platelets in patients leading to low platelet counts and bleeding. The diagnosis and effective management of ITP is challenging because there is no established test to confirm the disease and no biomarker with which one can predict the response to treatment and outcome. In this work we conduct a feasibility study to check if machine learning can be applied effectively for diagnosis of ITP using routine blood tests and demographic data in a non-acute outpatient setting. Various ML models, including Logistic Regression, Support Vector Machine, k-Nearest Neighbor, Decision Tree and Random Forest, were applied to data from the UK Adult ITP Registry and a general hematology clinic. Two different approaches were investigated: a demographic-unaware and a demographic-aware one. We conduct extensive experiments to evaluate the predictive performance of these models and approaches, as well as their bias. The results revealed that Decision Tree and Random Forest models were both superior and fair, achieving nearly perfect predictive and fairness scores, with platelet count identified as the most significant variable. Models not provided with demographic information performed better in terms of predictive accuracy but showed lower fairness score, illustrating a trade-off between predictive performance and fairness.

Symbolic Aggregate approXimation (SAX) is a common dimensionality reduction approach for time-series data which has been employed in a variety of domains, including classification and anomaly detection in time-series data. Domains also include shape recognition where the shape outline is converted into time-series data forinstance epoch classification of archived arrowheads. In this paper we propose a dimensionality reduction and shape recognition approach based on the SAX algorithm, an application which requires responses on cost efficient, IoT-like, platforms. The challenge is largely dealing with the computational expense of the SAX algorithm in IoT-like applications, from simple time-series dimension reduction through shape recognition. The approach is based on lowering the dimensional space while capturing and preserving the most representative features of the shape. We present three scenarios of increasing computational complexity backing up our statements with measurement of performance characteristics

Scientific hypotheses typically concern specific aspects of complex, imperfectly understood or entirely unknown mechanisms, such as the effect of gene expression levels on phenotypes or how microbial communities influence environmental health. Such queries are inherently causal (rather than purely associational), but in many settings, experiments can not be conducted directly on the target variables of interest, but are indirect. Therefore, they perturb the target variable, but do not remove potential confounding factors. If, additionally, the resulting experimental measurements are multi-dimensional and the studied mechanisms nonlinear, the query of interest is generally not identified. We develop an adaptive strategy to design indirect experiments that optimally inform a targeted query about the ground truth mechanism in terms of sequentially narrowing the gap between an upper and lower bound on the query. While the general formulation consists of a bi-level optimization procedure, we derive an efficiently estimable analytical kernel-based estimator of the bounds for the causal effect, a query of key interest, and demonstrate the efficacy of our approach in confounded, multivariate, nonlinear synthetic settings.

In this research, we introduce MIND-Crypt, a novel attack framework that uses deep learning (DL) and transfer learning (TL) to challenge the indistinguishability of block ciphers, specifically SPECK32/64 encryption algorithm in CBC mode (Cipher Block Chaining) against Known Plaintext Attacks (KPA). Our methodology includes training a DL model with ciphertexts of two messages encrypted using the same key. The selected messages have the same byte-length and differ by only one bit at the binary level. This DL model employs a residual network architecture. For the TL, we use the trained DL model as a feature extractor, and these features are then used to train a shallow machine learning, such as XGBoost. This dual strategy aims to distinguish ciphertexts of two encrypted messages, addressing traditional cryptanalysis challenges. Our findings demonstrate that the DL model achieves an accuracy of approximately 99% under consistent cryptographic conditions (Same Key or Rounds) with the SPECK32/64 cipher. However, performance degrades to random guessing levels (50%) when tested with ciphertext generated from different keys or different encryption rounds of SPECK32/64. To enhance the results, the DL model requires retraining with different keys or encryption rounds using larger datasets (10^7 samples). To overcome this limitation, we implement TL, achieving an accuracy of about 53% with just 10,000 samples, which is better than random guessing. Further training with 580,000 samples increases accuracy to nearly 99%, showing a substantial reduction in data requirements by over 94%. This shows that an attacker can utilize machine learning models to break indistinguishability by accessing pairs of plaintexts and their corresponding ciphertexts encrypted with the same key, without directly interacting with the communicating parties.

In federated learning, a server must periodically broadcast a model to the agents. We propose to use multi-resolution coding and modulation (also known as non-uniform modulation) for this purpose. In the simplest instance, broadcast transmission is used, whereby all agents are targeted with one and the same transmission (typically without any particular favored beam direction), which is coded using multi-resolution coding/modulation. This enables high-SNR agents, with high path gains to the server, to receive a more accurate model than the low-SNR agents do, without consuming more downlink resources. As one implementation, we use transmission with a non-uniform 8-PSK constellation, where a high-SNR receiver (agent) can separate all 8 constellation points (hence receive 3 bits) whereas a low-SNR receiver can only separate 4 points (hence receive 2 bits). By encoding the least significant information in the third bit, the high-SNR receivers can obtain the model with higher accuracy, while the low-SNR receiver can still obtain the model although with reduced accuracy, thereby facilitating at least some basic participation of the low-SNR receiver. We show the effectiveness of our proposed scheme via experimentation using federated learning with the MNIST data-set.

The increased availability of medical data has significantly impacted healthcare by enabling the application of machine / deep learning approaches in various instances. However, medical datasets are usually small and scattered across multiple providers, suffer from high class-imbalance, and are subject to stringent data privacy constraints. In this paper, the application of a data regularization algorithm, suitable for learning under high class-imbalance, in a federated learning setting is proposed. Specifically, the goal of the proposed method is to enhance model performance for cardiovascular disease prediction by tackling the class-imbalance that typically characterizes datasets used for this purpose, as well as by leveraging patient data available in different nodes of a federated ecosystem without compromising their privacy and enabling more resource sensitive allocation. The method is evaluated across four datasets for cardiovascular disease prediction, which are scattered across different clients, achieving improved performance. Meanwhile, its robustness under various hyperparameter settings, as well as its ability to adapt to different resource allocation scenarios, is verified.

In the evolving landscape of deep learning, selecting the best pre-trained models from a growing number of choices is a challenge. Transferability scorers propose alleviating this scenario, but their recent proliferation, ironically, poses the challenge of their own assessment. In this work, we propose both robust benchmark guidelines for transferability scorers, and a well-founded technique to combine multiple scorers, which we show consistently improves their results. We extensively evaluate 13 scorers from literature across 11 datasets, comprising generalist, fine-grained, and medical imaging datasets. We show that few scorers match the predictive performance of the simple raw metric of models on ImageNet, and that all predictors suffer on medical datasets. Our results highlight the potential of combining different information sources for reliably predicting transferability across varied domains.

The increasing popularity of machine learning (ML) in catalysis has spurred interest in leveraging these techniques to enhance catalyst design. Our study aims to bridge the gap between physics-based studies and data-driven methodologies by integrating ML techniques with eXplainable AI (XAI). Specifically, we employ two XAI techniques: Post-hoc XAI analysis and Symbolic Regression. These techniques help us unravel the correlation between adsorption energy and the properties of the adsorbate-catalyst system. Leveraging a large dataset such as the Open Catalyst Dataset (OC20), we employ a combination of shallow ML techniques and XAI methodologies. Our investigation involves utilizing multiple shallow machine learning techniques to predict adsorption energy, followed by post-hoc analysis for feature importance, inter-feature correlations, and the influence of various feature values on the prediction of adsorption energy. The post-hoc analysis reveals that adsorbate properties exert a greater influence than catalyst properties in our dataset. The top five features based on higher Shapley values are adsorbate electronegativity, the number of adsorbate atoms, catalyst electronegativity, effective coordination number, and the sum of atomic numbers of the adsorbate molecule. There is a positive correlation between catalyst and adsorbate electronegativity with the prediction of adsorption energy. Additionally, symbolic regression yields results consistent with SHAP analysis. It deduces a mathematical relationship indicating that the square of the catalyst electronegativity is directly proportional to the adsorption energy. These consistent correlations resemble those derived from physics-based equations in previous research. Our work establishes a robust framework that integrates ML techniques with XAI, leveraging large datasets like OC20 to enhance catalyst design through model explainability.

Capsule networks (CapsNets) were introduced to address convolutional neural networks limitations, learning object-centric representations that are more robust, pose-aware, and interpretable. They organize neurons into groups called capsules, where each capsule encodes the instantiation parameters of an object or one of its parts. Moreover, a routing algorithm connects capsules in different layers, thereby capturing hierarchical part-whole relationships in the data. This thesis investigates the intriguing aspects of CapsNets and focuses on three key questions to unlock their full potential. First, we explore the effectiveness of the routing algorithm, particularly in small-sized networks. We propose a novel method that anneals the number of routing iterations during training, enhancing performance in architectures with fewer parameters. Secondly, we investigate methods to extract more effective first-layer capsules, also known as primary capsules. By exploiting pruned backbones, we aim to improve computational efficiency by reducing the number of capsules while achieving high generalization. This approach reduces CapsNets memory requirements and computational effort. Third, we explore part-relationship learning in CapsNets. Through extensive research, we demonstrate that capsules with low entropy can extract more concise and discriminative part-whole relationships compared to traditional capsule networks, even with reasonable network sizes. Lastly, we showcase how CapsNets can be utilized in real-world applications, including autonomous localization of unmanned aerial vehicles, quaternion-based rotations prediction in synthetic datasets, and lung nodule segmentation in biomedical imaging. The findings presented in this thesis contribute to a deeper understanding of CapsNets and highlight their potential to address complex computer vision challenges.