Estimating causal effect using machine learning (ML) algorithms can help to relax functional form assumptions if used within appropriate frameworks. However, most of these frameworks assume settings with cross-sectional data, whereas researchers often have access to panel data, which in traditional methods helps to deal with unobserved heterogeneity between units. In this paper, we explore how we can adapt double/debiased machine learning (DML) (Chernozhukov et al., 2018) for panel data in the presence of unobserved heterogeneity. This adaptation is challenging because DML's cross-fitting procedure assumes independent data and the unobserved heterogeneity is not necessarily additively separable in settings with nonlinear observed confounding. We assess the performance of several intuitively appealing estimators in a variety of simulations. While we find violations of the cross-fitting assumptions to be largely inconsequential for the accuracy of the effect estimates, many of the considered methods fail to adequately account for the presence of unobserved heterogeneity. However, we find that using predictive models based on the correlated random effects approach (Mundlak, 1978) within DML leads to accurate coefficient estimates across settings, given a sample size that is large relative to the number of observed confounders. We also show that the influence of the unobserved heterogeneity on the observed confounders plays a significant role for the performance of most alternative methods.

Learning-based methods have gained attention as general-purpose solvers because they can automatically learn problem-specific heuristics, reducing the need for manually crafted heuristics. However, these methods often face challenges with scalability. To address these issues, the improved Sampling algorithm for Combinatorial Optimization (iSCO) using discrete Langevin dynamics has been proposed, demonstrating better performance than several learning-based solvers. This study proposes a different approach that integrates gradient-based update through continuous relaxation, combined with Quasi-Quantum Annealing (QQA). QQA smoothly transitions the objective function from a simple convex form, where half-integral solutions dominate, to the original objective function, where the variables are restricted to 0 or 1. Furthermore, we incorporate parallel run communication leveraging GPUs, enhancing exploration capabilities and accelerating convergence. Numerical experiments demonstrate that our approach is a competitive general-purpose solver, achieving comparable performance to iSCO across various benchmark problems. Notably, our method exhibits superior trade-offs between speed and solution quality for large-scale instances compared to iSCO, commercial solvers, and specialized algorithms.

Multimodal language modeling constitutes a recent breakthrough which leverages advances in large language models to pretrain capable multimodal models. The integration of natural language during pretraining has been shown to significantly improve learned representations, particularly in computer vision. However, the efficacy of multimodal language modeling in the realm of functional brain data, specifically for advancing pathology detection, remains unexplored. This study pioneers EEG-language models trained on clinical reports and 15000 EEGs. We extend methods for multimodal alignment to this novel domain and investigate which textual information in reports is useful for training EEG-language models. Our results indicate that models learn richer representations from being exposed to a variety of report segments, including the patient's clinical history, description of the EEG, and the physician's interpretation. Compared to models exposed to narrower clinical text information, we find such models to retrieve EEGs based on clinical reports (and vice versa) with substantially higher accuracy. Yet, this is only observed when using a contrastive learning approach. Particularly in regimes with few annotations, we observe that representations of EEG-language models can significantly improve pathology detection compared to those of EEG-only models, as demonstrated by both zero-shot classification and linear probes. In sum, these results highlight the potential of integrating brain activity data with clinical text, suggesting that EEG-language models represent significant progress for clinical applications.

These studies have been accelerated by 1) the increasing sophistication of information and communication technology, 2) large-scale data obtained through longitudinal studies, etc., and 3) the opening of program codes for building predictive models using machine learning. In particular, these studies have become even more active in recent years with the advent of automated machine learning framework [4-6]. As an example, published studies have applied MLA to data from the UK Biobank large longitudinal cohort study to develop models to diagnose and predict disease onset in advance [4, 7]. Such studies have been conducted previously, and in 1988, J. W. Smith et al. applied neural networks to data collected by the National Institute of Diabetes and Digestive and Kidney Diseases from a population of Pima Indians near Phoenix, Arizona, to predict the onset of diabetes [8-11]. This dataset, called the PID dataset, is still the primary dataset used to evaluate MLA in recent years, and in 2014, a method was proposed to combine multiple prediction models to predict onset of the disease, showing a very high prediction accuracy of 0.97 [12-17]. As mentioned above, a great deal of research has been published in recent years on predictive models of disease using machine learning. However, there are issues such as inadequate reporting of prediction models and lack of external validation [18].

Deterministic policy gradient algorithms are foundational for actor-critic methods in controlling continuous systems, yet they often encounter inaccuracies due to their dependence on the derivative of the critic's value estimates with respect to input actions. This reliance requires precise action-value gradient computations, a task that proves challenging under function approximation. We introduce an actor-critic algorithm that bypasses the need for such precision by employing a zeroth-order approximation of the action-value gradient through two-point stochastic gradient estimation within the action space. This approach provably and effectively addresses compatibility issues inherent in deterministic policy gradient schemes. Empirical results further demonstrate that our algorithm not only matches but frequently exceeds the performance of current state-of-the-art methods.

Traditional crime prediction techniques are slow and inefficient when generating predictions as crime increases rapidly \cite{r15}. To enhance traditional crime prediction methods, a Long Short-Term Memory and Gated Recurrent Unit model was constructed using datasets involving gender ratios, high school graduation rates, political status, unemployment rates, and median income by state over multiple years. While there may be other crime prediction tools, personalizing the model with hand picked factors allows a unique gap for the project. Producing an effective model would allow policymakers to strategically allocate specific resources and legislation in geographic areas that are impacted by crime, contributing to the criminal justice field of research \cite{r2A}. The model has an average total loss value of 70.792.30, and a average percent error of 9.74 percent, however both of these values are impacted by extreme outliers and with the correct optimization may be corrected.

Distributed Denial of Service (DDoS) attacks are a major concern in network security, as they overwhelm systems with excessive traffic, compromise sensitive data, and disrupt network services. Accurately detecting these attacks is crucial to protecting network infrastructure. Traditional approaches, such as single Convolutional Neural Networks (CNNs) or conventional Machine Learning (ML) algorithms like Decision Trees (DTs) and Support Vector Machines (SVMs), struggle to extract the diverse features needed for precise classification, resulting in suboptimal performance. This research addresses this gap by introducing a novel approach for DDoS attack detection. The proposed method combines three distinct CNN architectures: SA-Enabled CNN with XGBoost, SA-Enabled CNN with LSTM, and SA-Enabled CNN with Random Forest. Each model extracts features at multiple scales, while self-attention mechanisms enhance feature integration and relevance. The weighted ensemble approach ensures that both prominent and subtle features contribute to the final classification, improving adaptability to evolving attack patterns and novel threats. The proposed method achieves a precision of 98.71%, an F1-score of 98.66%, a recall of 98.63%, and an accuracy of 98.69%, outperforming traditional methods and setting a new benchmark in DDoS attack detection. This innovative approach addresses critical limitations in current models and advances the state of the art in network security.

Activity cliffs, which refer to pairs of molecules that are structurally similar but show significant differences in their potency, can lead to model representation collapse and make the model challenging to distinguish them. Our research indicates that as molecular similarity increases, graph-based methods struggle to capture these nuances, whereas image-based approaches effectively retain the distinctions. Thus, we developed MaskMol, a knowledge-guided molecular image self-supervised learning framework. MaskMol accurately learns the representation of molecular images by considering multiple levels of molecular knowledge, such as atoms, bonds, and substructures. By utilizing pixel masking tasks, MaskMol extracts fine-grained information from molecular images, overcoming the limitations of existing deep learning models in identifying subtle structural changes. Experimental results demonstrate MaskMol's high accuracy and transferability in activity cliff estimation and compound potency prediction across 20 different macromolecular targets, outperforming 25 state-of-the-art deep learning and machine learning approaches. Visualization analyses reveal MaskMol's high biological interpretability in identifying activity cliff-relevant molecular substructures. Notably, through MaskMol, we identified candidate EP4 inhibitors that could be used to treat tumors. This study not only raises awareness about activity cliffs but also introduces a novel method for molecular image representation learning and virtual screening, advancing drug discovery and providing new insights into structure-activity relationships (SAR).

The growth of digitalization services via web browsers has simplified our daily routine of doing business. But at the same time, it has made the web browser very attractive for several cyber-attacks. Web phishing is a well-known cyberattack that is used by attackers camouflaging as trustworthy web servers to obtain sensitive user information such as credit card numbers, bank information, personal ID, social security number, and username and passwords. In recent years many techniques have been developed to identify the authentic web pages that users visit and warn them when the webpage is phishing. In this paper, we have developed an extension for Chrome the most favorite web browser, that will serve as a middleware between the user and phishing websites. The Chrome extension named "NoPhish" shall identify a phishing webpage based on several Machine Learning techniques. We have used the training dataset from "PhishTank" and extracted the 22 most popular features as rated by the Alexa database. The training algorithms used are Random Forest, Support Vector Machine, and k-Nearest Neighbor. The performance results show that Random Forest delivers the best precision.

While Agent-Based Models can create detailed artificial societies based on individual differences and local context, they can be computationally intensive. Modelers may offset these costs through a parsimonious use of the model, for example by using smaller population sizes (which limits analyses in sub-populations), running fewer what-if scenarios, or accepting more uncertainty by performing fewer simulations. Alternatively, researchers may accelerate simulations via hardware solutions (e.g., GPU parallelism) or approximation approaches that operate a tradeoff between accuracy and compute time. In this paper, we present an approximation that combines agents who `think alike', thus reducing the population size and the compute time. Our innovation relies on representing agent behaviors as networks of rules (Fuzzy Cognitive Maps) and empirically evaluating different measures of distance between these networks. Then, we form groups of think-alike agents via community detection and simplify them to a representative agent. Case studies show that our simplifications remain accuracy.