Causal and nonparametric estimands in economics and biostatistics can often be viewed as the mean of a linear functional applied to an unknown outcome regression function. Naively learning the regression function and taking a sample mean of the target functional results in biased estimators, and a rich debiasing literature has developed where one additionally learns the so-called Riesz representer (RR) of the target estimand (targeted learning, double ML, automatic debiasing etc.). Learning the RR via its derived functional form can be challenging, e.g. due to extreme inverse probability weights or the need to learn conditional density functions. Such challenges have motivated recent advances in automatic debiasing (AD), where the RR is learned directly via minimization of a bespoke loss. We propose moment-constrained learning as a new RR learning approach that addresses some shortcomings in AD, constraining the predicted moments and improving the robustness of RR estimates to optimization hyperparamters. Though our approach is not tied to a particular class of learner, we illustrate it using neural networks, and evaluate on the problems of average treatment/derivative effect estimation using semi-synthetic data. Our numerical experiments show improved performance versus state of the art benchmarks.

Class imbalance in binary classification tasks remains a significant challenge in machine learning, often resulting in poor performance on minority classes. This study comprehensively evaluates three widely-used strategies for handling class imbalance: Synthetic Minority Over-sampling Technique (SMOTE), Class Weights tuning, and Decision Threshold Calibration. We compare these methods against a baseline scenario of no-intervention across 15 diverse machine learning models and 30 datasets from various domains, conducting a total of 9,000 experiments. Performance was primarily assessed using the F1-score, although our study also tracked results on additional 9 metrics including F2-score, precision, recall, Brier-score, PR-AUC, and AUC. Our results indicate that all three strategies generally outperform the baseline, with Decision Threshold Calibration emerging as the most consistently effective technique. However, we observed substantial variability in the best-performing method across datasets, highlighting the importance of testing multiple approaches for specific problems. This study provides valuable insights for practitioners dealing with imbalanced datasets and emphasizes the need for dataset-specific analysis in evaluating class imbalance handling techniques.

Conformal prediction is a popular technique for constructing prediction intervals with distribution-free coverage guarantees. The coverage is marginal, meaning it only holds on average over the entire population but not necessarily for any specific subgroup. This article introduces a new method, posterior conformal prediction (PCP), which generates prediction intervals with both marginal and approximate conditional validity for clusters (or subgroups) naturally discovered in the data. PCP achieves these guarantees by modelling the conditional conformity score distribution as a mixture of cluster distributions. Compared to other methods with approximate conditional validity, this approach produces tighter intervals, particularly when the test data is drawn from clusters that are well represented in the validation data. PCP can also be applied to guarantee conditional coverage on user-specified subgroups, in which case it achieves robust coverage on smaller subgroups within the specified subgroups. In classification, the theory underlying PCP allows for adjusting the coverage level based on the classifier's confidence, achieving significantly smaller sets than standard conformal prediction sets. We evaluate the performance of PCP on diverse datasets from socio-economic, scientific and healthcare applications.

Computational models are invaluable in capturing the complexities of real-world biological processes. Yet, the selection of appropriate algorithms for inference tasks, especially when dealing with real-world observational data, remains a challenging and underexplored area. This gap has spurred the development of various parameter estimation algorithms, particularly within the realm of Simulation-Based Inference (SBI), such as neural and statistical SBI methods. Limited research exists on how to make informed choices on SBI methods when faced with real-world data, which often results in some form of model misspecification. In this paper, we provide comprehensive guidelines for deciding between SBI approaches for complex biological models. We apply the guidelines to two agent-based models that describe cellular dynamics using real-world data. Our study unveils a critical insight: while neural SBI methods demand significantly fewer simulations for inference results, they tend to yield biased estimations, a trend persistent even with robust variants of these algorithms. On the other hand, the accuracy of statistical SBI methods enhances substantially as the number of simulations increases. This finding suggests that, given a sufficient computational budget, statistical SBI can surpass neural SBI in performance. Our results not only shed light on the efficacy of different SBI methodologies in real-world scenarios but also suggest potential avenues for enhancing neural SBI approaches. This study is poised to be a useful resource for computational biologists navigating the intricate landscape of SBI in biological modeling.

Transformers have achieved extraordinary success in modern machine learning due to their excellent ability to handle sequential data, especially in next-token prediction (NTP) tasks. However, the theoretical understanding of their performance in NTP is limited, with existing studies focusing mainly on asymptotic performance. This paper provides a fine-grained non-asymptotic analysis of the training dynamics of a one-layer transformer consisting of a self-attention module followed by a feed-forward layer. We first characterize the essential structural properties of training datasets for NTP using a mathematical framework based on partial orders. Then, we design a two-stage training algorithm, where the pre-processing stage for training the feed-forward layer and the main stage for training the attention layer exhibit fast convergence performance. Specifically, both layers converge sub-linearly to the direction of their corresponding max-margin solutions. We also show that the cross-entropy loss enjoys a linear convergence rate. Furthermore, we show that the trained transformer presents non-trivial prediction ability with dataset shift, which sheds light on the remarkable generalization performance of transformers. Our analysis technique involves the development of novel properties on the attention gradient and further in-depth analysis of how these properties contribute to the convergence of the training process. Our experiments further validate our theoretical findings.

Source Inference Attack (SIA) in Federated Learning (FL) aims to identify which client used a target data point for local model training. It allows the central server to audit clients' data usage. In cross-silo FL, a client (silo) collects data from multiple subjects (e.g., individuals, writers, or devices), posing a risk of subject information leakage. Subject Membership Inference Attack (SMIA) targets this scenario and attempts to infer whether any client utilizes data points from a target subject in cross-silo FL. However, existing results on SMIA are limited and based on strong assumptions on the attack scenario. Therefore, we propose a Subject-Level Source Inference Attack (SLSIA) by removing critical constraints that only one client can use a target data point in SIA and imprecise detection of clients utilizing target subject data in SMIA. The attacker, positioned on the server side, controls a target data source and aims to detect all clients using data points from the target subject. Our strategy leverages a binary attack classifier to predict whether the embeddings returned by a local model on test data from the target subject include unique patterns that indicate a client trains the model with data from that subject. To achieve this, the attacker locally pre-trains models using data derived from the target subject and then leverages them to build a training set for the binary attack classifier. Our SLSIA significantly outperforms previous methods on three datasets. Specifically, SLSIA achieves a maximum average accuracy of 0.88 over 50 target subjects. Analyzing embedding distribution and input feature distance shows that datasets with sparse subjects are more susceptible to our attack. Finally, we propose to defend our SLSIA using item-level and subject-level differential privacy mechanisms.

Speech signal processing is a cornerstone of modern communication technologies, tasked with improving the clarity and comprehensibility of audio data in noisy environments. The primary challenge in this field is the effective separation and recognition of speech from background noise, crucial for applications ranging from voice-activated assistants to automated transcription services. The quality of speech recognition directly impacts user experience and accessibility in technology-driven communication. This review paper explores advanced clustering techniques, particularly focusing on the Kernel Fuzzy C-Means (KFCM) method, to address these challenges. Our findings indicate that KFCM, compared to traditional methods like K-Means (KM) and Fuzzy C-Means (FCM), provides superior performance in handling non-linear and non-stationary noise conditions in speech signals. The most notable outcome of this review is the adaptability of KFCM to various noisy environments, making it a robust choice for speech enhancement applications. Additionally, the paper identifies gaps in current methodologies, such as the need for more dynamic clustering algorithms that can adapt in real time to changing noise conditions without compromising speech recognition quality. Key contributions include a detailed comparative analysis of current clustering algorithms and suggestions for further integrating hybrid models that combine KFCM with neural networks to enhance speech recognition accuracy. Through this review, we advocate for a shift towards more sophisticated, adaptive clustering techniques that can significantly improve speech enhancement and pave the way for more resilient speech processing systems.

Federated Learning (FL) provides a privacy-preserving framework for training machine learning models on mobile edge devices. Traditional FL algorithms, e.g., FedAvg, impose a heavy communication workload on these devices. To mitigate this issue, Hierarchical Federated Edge Learning (HFEL) has been proposed, leveraging edge servers as intermediaries for model aggregation. Despite its effectiveness, HFEL encounters challenges such as a slow convergence rate and high resource consumption, particularly in the presence of system and data heterogeneity. However, existing works are mainly focused on improving training efficiency for traditional FL, leaving the efficiency of HFEL largely unexplored. In this paper, we consider a two-tier HFEL system, where edge devices are connected to edge servers and edge servers are interconnected through peer-to-peer (P2P) edge backhauls. Our goal is to enhance the training efficiency of the HFEL system through strategic resource allocation and topology design. Specifically, we formulate an optimization problem to minimize the total training latency by allocating the computation and communication resources, as well as adjusting the P2P connections. To ensure convergence under dynamic topologies, we analyze the convergence error bound and introduce a model consensus constraint into the optimization problem. The proposed problem is then decomposed into several subproblems, enabling us to alternatively solve it online. Our method facilitates the efficient implementation of large-scale FL at edge networks under data and system heterogeneity. Comprehensive experiment evaluation on benchmark datasets validates the effectiveness of the proposed method, demonstrating significant reductions in training latency while maintaining the model accuracy compared to various baselines.

This study examines the clinical decision-making processes in Traditional East Asian Medicine (TEAM) by reinterpreting pattern identification (PI) through the lens of dimensionality reduction. Focusing on the Eight Principle Pattern Identification (EPPI) system and utilizing empirical data from the Shang-Han-Lun, we explore the necessity and significance of prioritizing the Exterior-Interior pattern in diagnosis and treatment selection. We test three hypotheses: whether the Ext-Int pattern contains the most information about patient symptoms, represents the most abstract and generalizable symptom information, and facilitates the selection of appropriate herbal prescriptions. Employing quantitative measures such as the abstraction index, cross-conditional generalization performance, and decision tree regression, our results demonstrate that the Exterior-Interior pattern represents the most abstract and generalizable symptom information, contributing to the efficient mapping between symptom and herbal prescription spaces. This research provides an objective framework for understanding the cognitive processes underlying TEAM, bridging traditional medical practices with modern computational approaches. The findings offer insights into the development of AI-driven diagnostic tools in TEAM and conventional medicine, with the potential to advance clinical practice, education, and research.

With the remarkable capability to reach the public instantly, social media has become integral in sharing scholarly articles to measure public response. Since spamming by bots on social media can steer the conversation and present a false public interest in given research, affecting policies impacting the public's lives in the real world, this topic warrants critical study and attention. We used the Altmetric dataset in combination with data collected through the Twitter Application Programming Interface (API) and the Botometer API. We combined the data into an extensive dataset with academic articles, several features from the article and a label indicating whether the article had excessive bot activity on Twitter or not. We analyzed the data to see the possibility of bot activity based on different characteristics of the article. We also trained machine-learning models using this dataset to identify possible bot activity in any given article. Our machine-learning models were capable of identifying possible bot activity in any academic article with an accuracy of 0.70. We also found that articles related to "Health and Human Science" are more prone to bot activity compared to other research areas. Without arguing the maliciousness of the bot activity, our work presents a tool to identify the presence of bot activity in the dissemination of an academic article and creates a baseline for future research in this direction.