Accurately identifying cancer samples is crucial for precise diagnosis and effective patient treatment. Traditional methods falter with high-dimensional and high feature-to-sample count ratios, which are critical for classifying cancer samples. This study aims to develop a novel feature selection framework specifically for transcriptome data and propose two ensemble classifiers. For feature selection, we partition the transcriptome dataset vertically based on feature types. Then apply the Boruta feature selection process on each of the partitions, combine the results, and apply Boruta again on the combined result. We repeat the process with different parameters of Boruta and prepare the final feature set. Finally, we constructed two ensemble ML models based on LR, SVM and XGBoost classifiers with max voting and averaging probability approach. We used 10-fold cross-validation to ensure robust and reliable classification performance. With 97.11\% accuracy and 0.9996 AUC value, our approach performs better compared to existing state-of-the-art methods to classify 33 types of cancers. A set of 12 types of cancer is traditionally challenging to differentiate between each other due to their similarity in tissue of origin. Our method accurately identifies over 90\% of samples from these 12 types of cancers, which outperforms all known methods presented in existing literature. The gene set enrichment analysis reveals that our framework's selected features have enriched the pathways highly related to cancers. This study develops a feature selection framework to select features highly related to cancer development and leads to identifying different types of cancer samples with higher accuracy.

Among different interesting problems in XAI, explaining classifiers' decisions has attracted significant attention[Bae+10; MI22; Mar24]. Work in this area has proposed notions to explain classifiers' behavior on a specific feature vector (instance), providing so-called local explanations, as well as notions to explain the overall classifier's behavior regardless of any particular instance, providing so-called global explanations. For both notions, a key issue is to analyze the computational complexity of the problems at hand, since this is crucial to understand how to approach the development of algorithmic solutions and their inherent limits. In the field of XAI, there has been an extensive body of work addressing complexity issues[BAK24; OPS23; Are+23; CM23; CA23; CCM23; Hua+22; Aud+22; CM22; Bar+20a; Mar+20] This paper falls within this ongoing research stream. Specifically, we deal with global explanations, and focus on so-called global necessary reasons, defined as conditions that instances must satisfy in order to be classified with a class of interest. This notion has been considered by Ignatiev, Narodytska, and Marques-Silva[INM19], where an interesting relationship with another kind of global explanation is shown.

Fairness in machine learning (ML) has garnered significant attention in recent years. While existing research has predominantly focused on the distributive fairness of ML models, there has been limited exploration of procedural fairness. This paper proposes a novel method to achieve procedural fairness during the model training phase. The effectiveness of the proposed method is validated through experiments conducted on one synthetic and six real-world datasets. Additionally, this work studies the relationship between procedural fairness and distributive fairness in ML models. On one hand, the impact of dataset bias and the procedural fairness of ML model on its distributive fairness is examined. The results highlight a significant influence of both dataset bias and procedural fairness on distributive fairness. On the other hand, the distinctions between optimizing procedural and distributive fairness metrics are analyzed. Experimental results demonstrate that optimizing procedural fairness metrics mitigates biases introduced or amplified by the decision-making process, thereby ensuring fairness in the decision-making process itself, as well as improving distributive fairness. In contrast, optimizing distributive fairness metrics encourages the ML model's decision-making process to favor disadvantaged groups, counterbalancing the inherent preferences for advantaged groups present in the dataset and ultimately achieving distributive fairness.

Due to the increasing abuse of fraudulent activities that result in significant financial and reputational harm, Ethereum smart contracts face a significant problem in detecting fraud. Existing monitoring methods typically rely on lease code analysis or physically extracted features, which suffer from scalability and adaptability limitations. In this study, we use graph representation learning to observe purchase trends and find fraudulent deals. We can achieve powerful categorisation performance by using innovative machine learning versions and transforming Ethereum invoice data into graph structures. Our method addresses label imbalance through SMOTE-ENN techniques and evaluates models like Multi-Layer Perceptron ( MLP ) and Graph Convolutional Networks ( GCN). Experimental results show that the MLP type surpasses the GCN in this environment, with domain-specific assessments closely aligned with real-world assessments. This study provides a scalable and efficient way to improve Ethereum's ecosystem's confidence and security.

Partial Differential Equations (PDEs) underpin many scientific phenomena, yet traditional computational approaches often struggle with complex, nonlinear systems and irregular geometries. This paper introduces the \textbf{AMG} method, a \textbf{M}ulti-\textbf{G}raph neural operator approach designed for efficiently solving PDEs on \textbf{A}rbitrary geometries. AMG leverages advanced graph-based techniques and dynamic attention mechanisms within a novel GraphFormer architecture, enabling precise management of diverse spatial domains and complex data interdependencies. By constructing multi-scale graphs to handle variable feature frequencies and a physics graph to encapsulate inherent physical properties, AMG significantly outperforms previous methods, which are typically limited to uniform grids. We present a comprehensive evaluation of AMG across six benchmarks, demonstrating its consistent superiority over existing state-of-the-art models. Our findings highlight the transformative potential of tailored graph neural operators in surmounting the challenges faced by conventional PDE solvers. Our code and datasets are available on \url{https://github.com/lizhihao2022/AMG}.

With the rapid advancement of AI systems, their abilities to store, retrieve, and utilize information over the long term - referred to as long-term memory - have become increasingly significant. These capabilities are crucial for enhancing the performance of AI systems across a wide range of tasks. However, there is currently no comprehensive survey that systematically investigates AI's long-term memory capabilities, formulates a theoretical framework, and inspires the development of next-generation AI long-term memory systems. This paper begins by introducing the mechanisms of human long-term memory, then explores AI long-term memory mechanisms, establishing a mapping between the two. Based on the mapping relationships identified, we extend the current cognitive architectures and propose the Cognitive Architecture of Self-Adaptive Long-term Memory (SALM). SALM provides a theoretical framework for the practice of AI long-term memory and holds potential for guiding the creation of next-generation long-term memory driven AI systems. Finally, we delve into the future directions and application prospects of AI long-term memory.

Double reinforcement learning (DRL) enables statistically efficient inference on the value of a policy in a nonparametric Markov Decision Process (MDP) given trajectories generated by another policy. However, this approach necessarily requires stringent overlap between the state distributions, which is often violated in practice. To relax this requirement and extend DRL, we study efficient inference on linear functionals of the $Q$-function (of which policy value is a special case) in infinite-horizon, time-invariant MDPs under semiparametric restrictions on the $Q$-function. These restrictions can reduce the overlap requirement and lower the efficiency bound, yielding more precise estimates. As an important example, we study the evaluation of long-term value under domain adaptation, given a few short trajectories from the new domain and restrictions on the difference between the domains. This can be used for long-term causal inference. Our method combines flexible estimates of the $Q$-function and the Riesz representer of the functional of interest (e.g., the stationary state density ratio for policy value) and is automatic in that we do not need to know the form of the latter - only the functional we care about. To address potential model misspecification bias, we extend the adaptive debiased machine learning (ADML) framework of \citet{van2023adaptive} to construct nonparametrically valid and superefficient estimators that adapt to the functional form of the $Q$-function. As a special case, we propose a novel adaptive debiased plug-in estimator that uses isotonic-calibrated fitted $Q$-iteration - a new calibration algorithm for MDPs - to circumvent the computational challenges of estimating debiasing nuisances from min-max objectives.

Many problems within personalized medicine and digital health rely on the analysis of continuous-time functional biomarkers and other complex data structures emerging from high-resolution patient monitoring. In this context, this work proposes new optimization-based variable selection methods for multivariate, functional, and even more general outcomes in metrics spaces based on best-subset selection. Our framework applies to several types of regression models, including linear, quantile, or non parametric additive models, and to a broad range of random responses, such as univariate, multivariate Euclidean data, functional, and even random graphs. Our analysis demonstrates that our proposed methodology outperforms state-of-the-art methods in accuracy and, especially, in speed-achieving several orders of magnitude improvement over competitors across various type of statistical responses as the case of mathematical functions. While our framework is general and is not designed for a specific regression and scientific problem, the article is self-contained and focuses on biomedical applications. In the clinical areas, serves as a valuable resource for professionals in biostatistics, statistics, and artificial intelligence interested in variable selection problem in this new technological AI-era.

Aquaculture involves cultivating marine and freshwater organisms, with real-time monitoring of aquatic parameters being crucial in fish farming. This thesis proposes an IoT-based framework using sensors and Arduino for efficient monitoring and control of water quality. Different sensors including pH, temperature, and turbidity are placed in cultivating pond water and each of them is connected to a common microcontroller board built on an Arduino Uno. The sensors read the data from the water and store it as a CSV file in an IoT cloud named Thingspeak through the Arduino Microcontroller. In the experimental part, we collected data from 5 ponds with various sizes and environments. After getting the real-time data, we compared these with the standard reference values. As a result, we can make the decision about which ponds are satisfactory for cultivating fish and what is not. After that, we labeled the data with 11 fish categories including Katla, sing, prawn, rui, koi, pangas, tilapia, silvercarp, karpio, magur, and shrimp. In addition, the data were analyzed using 10 machine learning (ML) algorithms containing J48, Random Forest, K-NN, K*, LMT, REPTree, JRIP, PART, Decision Table, and Logit boost. After experimental evaluation, it was observed among 5 ponds, only three ponds were perfect for fish farming, where these 3 ponds only satisfied the standard reference values of pH (6.5-8.5), Temperature (16-24)oC, Turbidity (below 10)ntu, Conductivity (970-1825){\mu}S/cm, and Depth (1-4) meter. Among the state-of-the-art machine learning algorithms, Random Forest achieved the highest score of performance metrics as accuracy 94.42%, kappa statistics 93.5%, and Avg. TP Rate 94.4%. In addition, we calculated the BOD, COD, and DO for one scenario. This study includes details of the proposed IoT system's prototype hardware.

Micro-delivery services offer promising solutions for on-demand city logistics, but their success relies on efficient real-time delivery operations and fleet management. On-demand meal delivery platforms seek to optimize real-time operations based on anticipatory insights into citywide demand distributions. To address these needs, this study proposes a short-term predict-then-cluster framework for on-demand meal delivery services. The framework utilizes ensemble-learning methods for point and distributional forecasting with multivariate features, including lagged-dependent inputs to capture demand dynamics. We introduce Constrained K-Means Clustering (CKMC) and Contiguity Constrained Hierarchical Clustering with Iterative Constraint Enforcement (CCHC-ICE) to generate dynamic clusters based on predicted demand and geographical proximity, tailored to user-defined operational constraints. Evaluations of European and Taiwanese case studies demonstrate that the proposed methods outperform traditional time series approaches in both accuracy and computational efficiency. Clustering results demonstrate that the incorporation of distributional predictions effectively addresses demand uncertainties, improving the quality of operational insights. Additionally, a simulation study demonstrates the practical value of short-term demand predictions for proactive strategies, such as idle fleet rebalancing, significantly enhancing delivery efficiency. By addressing demand uncertainties and operational constraints, our predict-then-cluster framework provides actionable insights for optimizing real-time operations. The approach is adaptable to other on-demand platform-based city logistics and passenger mobility services, promoting sustainable and efficient urban operations.