The Alzheimer's Disease Analysis Model Generation 1 (ADAM) is a multi-agent large language model (LLM) framework designed to integrate and analyze multi-modal data, including microbiome profiles, clinical datasets, and external knowledge bases, to enhance the understanding and detection of Alzheimer's disease (AD). By leveraging retrieval-augmented generation (RAG) techniques along with its multi-agent architecture, ADAM-1 synthesizes insights from diverse data sources and contextualizes findings using literature-driven evidence. Comparative evaluation against XGBoost revealed similar mean F1 scores but significantly reduced variance for ADAM-1, highlighting its robustness and consistency, particularly in small laboratory datasets. While currently tailored for binary classification tasks, future iterations aim to incorporate additional data modalities, such as neuroimaging and biomarkers, to broaden the scalability and applicability for Alzheimer's research and diagnostics.

Reliance on anonymity in social media has increased its popularity on these platforms among all ages. The availability of public Wi-Fi networks has facilitated a vast variety of online content, including social media applications. Although anonymity and ease of access can be a convenient means of communication for their users, it is difficult to manage and protect its vulnerable users against sexual predators. Using an automated identification system that can attribute predators to their text would make the solution more attainable. In this survey, we provide a review of the methods of pedophile attribution used in social media platforms. We examine the effect of the size of the suspect set and the length of the text on the task of attribution. Moreover, we review the most-used datasets, features, classification techniques and performance measures for attributing sexual predators. We found that few studies have proposed tools to mitigate the risk of online sexual predators, but none of them can provide suspect attribution. Finally, we list several open research problems.

This paper presents a framework for privacy-preserving verification of machine learning models, focusing on models trained on sensitive data. Integrating Local Differential Privacy (LDP) with model explanations from LIME and SHAP, our framework enables robust verification without compromising individual privacy. It addresses two key tasks: binary classification, to verify if a target model was trained correctly by applying the appropriate preprocessing steps, and multi-class classification, to identify specific preprocessing errors. Evaluations on three real-world datasets-Diabetes, Adult, and Student Record-demonstrate that while the ML-based approach is particularly effective in binary tasks, the threshold-based method performs comparably in multi-class tasks. Results indicate that although verification accuracy varies across datasets and noise levels, the framework provides effective detection of preprocessing errors, strong privacy guarantees, and practical applicability for safeguarding sensitive data.

Quantum Machine Learning (QML) offers significant potential for complex tasks like genome sequence classification, but quantum noise on Noisy Intermediate-Scale Quantum (NISQ) devices poses practical challenges. This study systematically evaluates how various quantum noise models including dephasing, amplitude damping, depolarizing, thermal noise, bit-flip, and phase-flip affect key QML algorithms (QSVC, Peg-QSVC, QNN, VQC) and feature mapping techniques (ZFeatureMap, ZZFeatureMap, and PauliFeatureMap). Results indicate that QSVC is notably robust under noise, whereas Peg-QSVC and QNN are more sensitive, particularly to depolarizing and amplitude-damping noise. The PauliFeatureMap is especially vulnerable, highlighting difficulties in maintaining accurate classification under noisy conditions. These findings underscore the critical importance of feature map selection and noise mitigation strategies in optimizing QML for genomic classification, with promising implications for personalized medicine.

Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by employing various feature mapping techniques. We present an open-source, independent Qiskit-based implementation to conduct experiments on a benchmark genomic dataset. Our simulations reveal that the interplay between feature mapping techniques and QML algorithms significantly influences performance. Notably, the Pegasos Quantum Support Vector Classifier (Pegasos-QSVC) exhibits high sensitivity, particularly excelling in recall metrics, while Quantum Neural Networks (QNN) achieve the highest training accuracy across all feature maps. However, the pronounced variability in classifier performance, dependent on feature mapping, highlights the risk of overfitting to localized output distributions in certain scenarios. This work underscores the transformative potential of QML for genomic data classification while emphasizing the need for continued advancements to enhance the robustness and accuracy of these methodologies.

Supervised machine learning classifiers often encounter challenges related to performance, accuracy, and overfitting. This paper introduces the Artificial Liver Classifier (ALC), a novel supervised learning classifier inspired by the human liver's detoxification function. The ALC is characterized by its simplicity, speed, hyperparameters-free, ability to reduce overfitting, and effectiveness in addressing multi-classification problems through straightforward mathematical operations. To optimize the ALC's parameters, an improved FOX optimization algorithm (IFOX) is employed as the training method. The proposed ALC was evaluated on five benchmark machine learning datasets: Iris Flower, Breast Cancer Wisconsin, Wine, Voice Gender, and MNIST. The results demonstrated competitive performance, with the ALC achieving 100% accuracy on the Iris dataset, surpassing logistic regression, multilayer perceptron, and support vector machine. Similarly, on the Breast Cancer dataset, it achieved 99.12% accuracy, outperforming XGBoost and logistic regression. Across all datasets, the ALC consistently exhibited lower overfitting gaps and loss compared to conventional classifiers. These findings highlight the potential of leveraging biological process simulations to develop efficient machine learning models and open new avenues for innovation in the field.

Transfer learning of prediction models has been extensively studied, while the corresponding policy learning approaches are rarely discussed. In this paper, we propose principled approaches for learning the optimal policy in the target domain by leveraging two datasets: one with full information from the source domain and the other from the target domain with only covariates. First, under the setting of covariate shift, we formulate the problem from a perspective of causality and present the identifiability assumptions for the reward induced by a given policy. Then, we derive the efficient influence function and the semiparametric efficiency bound for the reward. Based on this, we construct a doubly robust and semiparametric efficient estimator for the reward and then learn the optimal policy by optimizing the estimated reward. Moreover, we theoretically analyze the bias and the generalization error bound for the learned policy. Furthermore, in the presence of both covariate and concept shifts, we propose a novel sensitivity analysis method to evaluate the robustness of the proposed policy learning approach. Extensive experiments demonstrate that the approach not only estimates the reward more accurately but also yields a policy that closely approximates the theoretically optimal policy.

As urbanization accelerates, open spaces are increasingly recognized for their role in enhancing sustainability and well-being, yet they remain underexplored compared to built spaces. This study introduces an AI-driven framework that integrates machine learning models (MLMs) and explainable AI techniques to optimize Sky View Factor (SVF) and visibility, key spatial metrics influencing thermal comfort and perceived safety in urban spaces. Unlike global optimization methods, which are computationally intensive and impractical for localized adjustments, this framework supports incremental design improvements with lower computational costs and greater flexibility. The framework employs SHapley Adaptive Explanations (SHAP) to analyze feature importance and Counterfactual Explanations (CFXs) to propose minimal design changes. Simulations tested five MLMs, identifying XGBoost as the most accurate, with building width, park area, and heights of surrounding buildings as critical for SVF, and distances from southern buildings as key for visibility. Compared to Genetic Algorithms, which required approximately 15/30 minutes across 3/4 generations to converge, the tested CFX approach achieved optimized results in 1 minute with a 5% RMSE error, demonstrating significantly faster performance and suitability for scalable retrofitting strategies. This interpretable and computationally efficient framework advances urban performance optimization, providing data-driven insights and practical retrofitting solutions for enhancing usability and environmental quality across diverse urban contexts.

Variational Autoencoders (VAEs) have emerged as a powerful tool for unsupervised learning, offering a framework to model complex, high-dimensional data through probabilistic inference [1, 2]. Unlike traditional autoencoders, VAEs integrate principles from Bayesian inference, allowing them to generate and reconstruct data by learning latent representations that are both interpretable and continuous [3]. This paradigm has proven particularly valuable in fields dealing with intricate and multidimensional datasets, such as neuroimaging. Neuroimaging data, which includes structural and functional brain scans, often exhibits high dimensionality, noise, and heterogeneity. These characteristics make traditional machine learning approaches prone to overfitting or limited generalization [4]. Moreover, the integration of neuroimaging data with other modalities--such as cognitive assessments, cerebrospinal fluid markers, or genetic information--requires robust generative models capable of capturing complex relationships while preserving interpretability. This challenge is particularly crucial when integrating multimodal datasets, such as combining structural brain scans with genetic or cognitive markers.

Current evaluations of defenses against prompt attacks in large language model (LLM) applications often overlook two critical factors: the dynamic nature of adversarial behavior and the usability penalties imposed on legitimate users by restrictive defenses. We propose D-SEC (Dynamic Security Utility Threat Model), which explicitly separates attackers from legitimate users, models multi-step interactions, and rigorously expresses the security-utility in an optimizable form. We further address the shortcomings in existing evaluations by introducing Gandalf, a crowd-sourced, gamified red-teaming platform designed to generate realistic, adaptive attack datasets. Using Gandalf, we collect and release a dataset of 279k prompt attacks. Complemented by benign user data, our analysis reveals the interplay between security and utility, showing that defenses integrated in the LLM (e.g., system prompts) can degrade usability even without blocking requests. We demonstrate that restricted application domains, defense-in-depth, and adaptive defenses are effective strategies for building secure and useful LLM applications. Code is available at \href{https://github.com/lakeraai/dsec-gandalf}{\texttt{https://github.com/lakeraai/dsec-gandalf}}.