In intelligent transportation systems (ITS), traffic management departments rely on sensors, cameras, and GPS devices to collect real-time traffic data. Traffic speed data is often incomplete due to sensor failures, data transmission delays, or occlusions, resulting in missing speed data in certain road segments. Currently, tensor decomposition based methods are extensively utilized, they mostly rely on the $L_2$-norm to construct their learning objectives, which leads to reduced robustness in the algorithms. To address this, we propose Temporal-Aware Traffic Speed Imputation (TATSI), which combines the $L_2$-norm and smooth $L_1$ (${SL}_1$)-norm in its loss function, thereby achieving both high accuracy and robust performance in imputing missing time-varying traffic speed data. TATSI adopts a single latent factor-dependent, nonnegative, and multiplicative update (SLF-NMU) approach, which serves as an efficient solver for performing nonnegative latent factor analysis (LFA) on a tensor. Empirical studies on three real-world time-varying traffic speed datasets demonstrate that, compared with state-of-the-art traffic speed predictors, TATSI more precisely captures temporal patterns, thereby yielding the most accurate imputations for missing traffic speed data.

In recent years, Channel State Information (CSI), recognized for its fine-grained spatial characteristics, has attracted increasing attention in WiFi-based indoor localization. However, despite its potential, CSI-based approaches have yet to achieve the same level of deployment scale and commercialization as those based on Received Signal Strength Indicator (RSSI). A key limitation lies in the fact that most existing CSI-based systems are developed and evaluated in controlled, small-scale environments, limiting their generalizability. To bridge this gap, we explore the deployment of a large-scale CSI-based localization system involving over 400 Access Points (APs) in a real-world building under the Integrated Sensing and Communication (ISAC) paradigm. We highlight two critical yet often overlooked factors: the underutilization of unlabeled data and the inherent heterogeneity of CSI measurements. To address these challenges, we propose a novel CSI-based learning framework for WiFi localization, tailored for large-scale ISAC deployments on the server side. Specifically, we employ a novel graph-based structure to model heterogeneous CSI data and reduce redundancy. We further design a pretext pretraining task that incorporates spatial and temporal priors to effectively leverage large-scale unlabeled CSI data. Complementarily, we introduce a confidence-aware fine-tuning strategy to enhance the robustness of localization results. In a leave-one-smartphone-out experiment spanning five floors and 25, 600 m2, we achieve a median localization error of 2.17 meters and a floor accuracy of 99.49%. This performance corresponds to an 18.7% reduction in mean absolute error (MAE) compared to the best-performing baseline.

Unresolved questions about how autonomous vehicles (AVs) should meet the informational needs of riders hinder real-world adoption. Complicating our ability to satisfy rider needs is that different people, goals, and driving contexts have different criteria for what constitutes interaction success. Unfortunately, most human-AV research and design today treats all people and situations uniformly. It is crucial to understand how an AV should communicate to meet rider needs, and how communications should change when the human-AV complex system changes. I argue that understanding the relationships between different aspects of the human-AV system can help us build improved and adaptable AV communications. I support this argument using three empirical studies. First, I identify optimal communication strategies that enhance driving performance, confidence, and trust for learning in extreme driving environments. Findings highlight the need for task-sensitive, modality-appropriate communications tuned to learner cognitive limits and goals. Next, I highlight the consequences of deploying faulty communication systems and demonstrate the need for context-sensitive communications. Third, I use machine learning (ML) to illuminate personal factors predicting trust in AVs, emphasizing the importance of tailoring designs to individual traits and concerns. Together, this dissertation supports the necessity of transparent, adaptable, and personalized AV systems that cater to individual needs, goals, and contextual demands. By considering the complex system within which human-AV interactions occur, we can deliver valuable insights for designers, researchers, and policymakers. This dissertation also provides a concrete domain to study theories of human-machine joint action and situational awareness, and can be used to guide future human-AI interaction research. [shortened for arxiv]

The subcellular localization of RNAs, including long non-coding RNAs (lncRNAs), messenger RNAs (mRNAs), microRNAs (miRNAs) and other smaller RNAs, plays a critical role in determining their biological functions. For instance, lncRNAs are predominantly associated with chromatin and act as regulators of gene transcription and chromatin structure, while mRNAs are distributed across the nucleus and cytoplasm, facilitating the transport of genetic information for protein synthesis. Understanding RNA localization sheds light on processes like gene expression regulation with spatial and temporal precision. However, traditional wet lab methods for determining RNA localization, such as in situ hybridization, are often time-consuming, resource-demanding, and costly. To overcome these challenges, computational methods leveraging artificial intelligence (AI) and machine learning (ML) have emerged as powerful alternatives, enabling large-scale prediction of RNA subcellular localization. This paper provides a comprehensive review of the latest advancements in AI-based approaches for RNA subcellular localization prediction, covering various RNA types and focusing on sequence-based, image-based, and hybrid methodologies that combine both data types. We highlight the potential of these methods to accelerate RNA research, uncover molecular pathways, and guide targeted disease treatments. Furthermore, we critically discuss the challenges in AI/ML approaches for RNA subcellular localization, such as data scarcity and lack of benchmarks, and opportunities to address them. This review aims to serve as a valuable resource for researchers seeking to develop innovative solutions in the field of RNA subcellular localization and beyond.

Dynamic positron emission tomography (PET) with [ 18 F]FDG enables non-invasive quantification of glucose metabolism through kinetic analysis, often modelled by the two-tissue compartment model (TCKM). However, voxel-wise kinetic parameter estimation using conventional methods is computationally intensive and limited by spatial resolution. Deep neural networks (DNNs) offer an alternative but require large training datasets and significant computational resources. To address these limitations, we propose a physiological neural representation based on implicit neural representations (INRs) for personalized kinetic parameter estimation. INRs, which learn continuous functions, allow for efficient, high-resolution parametric imaging with reduced data requirements. Our method also integrates anatomical priors from a 3D CT foundation model to enhance robustness and precision in kinetic modelling. We evaluate our approach on an [ 18 F]FDG dynamic PET/CT dataset and compare it to state-of-the-art DNNs. Results demonstrate superior spatial resolution, lower mean-squared error, and improved anatomical consistency, particularly in tumour and highly vascularized regions. Our findings highlight the potential of INRs for personalized, data-efficient tracer kinetic modelling, enabling applications in tumour characterization, segmentation, and prognostic assessment.

The sea surface temperature (SST), a key environmental parameter, is crucial to optimizing production planning, making its accurate prediction a vital research topic. However, the inherent nonlinearity of the marine dynamic system presents significant challenges. Current forecasting methods mainly include physics-based numerical simulations and data-driven machine learning approaches. The former, while describing SST evolution through differential equations, suffers from high computational complexity and limited applicability, whereas the latter, despite its computational benefits, requires large datasets and faces interpretability challenges. This study presents a prediction framework based solely on data-driven techniques. Using phase space reconstruction, we construct initial-delay attractor pairs with a mathematical homeomorphism and design a Spatio-Temporal Fusion Mapping (STFM) to uncover their intrinsic connections. Unlike conventional models, our method captures SST dynamics efficiently through phase space reconstruction and achieves high prediction accuracy with minimal training data in comparative tests

The inference of gene regulatory networks (GRNs) is a foundational stride towards deciphering the fundamentals of complex biological systems. Inferring a possible regulatory link between two genes can be formulated as a link prediction problem. Inference of GRNs via gene coexpression profiling data may not always reflect true biological interactions, as its susceptibility to noise and misrepresenting true biological regulatory relationships. Most GRN inference methods face several challenges in the network reconstruction phase. Therefore, it is important to encode gene expression values, leverege the prior knowledge gained from the available inferred network structures and positional informations of the input network nodes towards inferring a better and more confident GRN network reconstruction. In this paper, we explore the integration of multiple inferred networks to enhance the inference of Gene Regulatory Networks (GRNs). Primarily, we employ autoencoder embeddings to capture gene expression patterns directly from raw data, preserving intricate biological signals. Then, we embed the prior knowledge from GRN structures transforming them into a text-like representation using random walks, which are then encoded with a masked language model, BERT, to generate global embeddings for each gene across all networks. Additionally, we embed the positional encodings of the input gene networks to better identify the position of each unique gene within the graph. These embeddings are integrated into graph transformer-based model, termed GT-GRN, for GRN inference. The GT-GRN model effectively utilizes the topological structure of the ground truth network while incorporating the enriched encoded information. Experimental results demonstrate that GT-GRN significantly outperforms existing GRN inference methods, achieving superior accuracy and highlighting the robustness of our approach.

Graph Contrastive Learning (GCL) has recently made progress as an unsupervised graph representation learning paradigm. GCL approaches can be categorized into augmentation-based and augmentation-free methods. The former relies on complex data augmentations, while the latter depends on encoders that can generate distinct views of the same input. Both approaches may require negative samples for training. In this paper, we introduce a novel augmentation-free GCL framework based on graph neural diffusion models. Specifically, we utilize learnable encoders governed by Fractional Differential Equations (FDE). Each FDE is characterized by an order parameter of the differential operator. We demonstrate that varying these parameters allows us to produce learnable encoders that generate diverse views, capturing either local or global information, for contrastive learning. Our model does not require negative samples for training and is applicable to both homophilic and heterophilic datasets. We demonstrate its effectiveness across various datasets, achieving state-of-the-art performance.

It often happens that some sensitive personal information, such as credit card numbers or passwords, are mistakenly incorporated in the training of machine learning models and need to be removed afterwards. The removal of such information from a trained model is a complex task that needs to partially reverse the training process. There have been various machine unlearning techniques proposed in the literature to address this problem. Most of the proposed methods revolve around removing individual data samples from a trained model. Another less explored direction is when features/labels of a group of data samples need to be reverted. While the existing methods for these tasks do the unlearning task by updating the whole set of model parameters or only the last layer of the model, we show that there are a subset of model parameters that have the largest contribution in the unlearning target features. More precisely, the model parameters with the largest corresponding diagonal value in the Hessian matrix (computed at the learned model parameter) have the most contribution in the unlearning task. By selecting these parameters and updating them during the unlearning stage, we can have the most progress in unlearning. We provide theoretical justifications for the proposed strategy by connecting it to sharpness-aware minimization and robust unlearning. We empirically show the effectiveness of the proposed strategy in improving the efficacy of unlearning with a low computational cost.

The whiskers extend to 4x the IQR ( Supplementary Figure 1), which is a conservative threshold that ensures only the most extreme variations in PL are classified as outliers (denoted by diamond symbols). Outliers in PL property distributions may indicate experimental errors, sample inconsistencies, or data proces sing anomalies, thus, they are removed from the ML analysis. Data Visualization: PCA orthogonally transforms the original variables into a new set of linearly uncorrelated variables termed principal components (PCs). The first PC captures the maximum variance present in the data, and each subsequent component has the highest variance p ossible under the constraint of being orthogonal to the preceding ones. The methodology involves standardizing the dataset, calculating the covariance matrix, and then extracting the eigenvalues and eigenvectors of this matrix, which, in tur n, dictate the magnitude and direction of the new space, respectively. By projecting the original data along these new axes, PCA provides a means to reduce the dimensionality of the dataset. Supplementary Figure 1A illustrates the distribution of the samples in the space defined by the PCs, with each point representing a single sample's location within this novel coordinate system. Here, the colors indicate the value of each PL property, offering a visual insight into how these factors correlate with the PCs.