Understanding the distinction between causation and correlation is critical in Alzheimer's disease (AD) research, as it impacts diagnosis, treatment, and the identification of true disease drivers. This experiment investigates the relationships among clinical, cognitive, genetic, and biomarker features using a combination of correlation analysis, machine learning classification, and model interpretability techniques. Employing the XGBoost algorithm, we identified key features influencing AD classification, including cognitive scores and genetic risk factors. Correlation matrices revealed clusters of interrelated variables, while SHAP (SHapley Additive exPlanations) values provided detailed insights into feature contributions across disease stages. Our results highlight that strong correlations do not necessarily imply causation, emphasizing the need for careful interpretation of associative data. By integrating feature importance and interpretability with classical statistical analysis, this work lays groundwork for future causal inference studies aimed at uncovering true pathological mechanisms. Ultimately, distinguishing causal factors from correlated markers can lead to improved early diagnosis and targeted interventions for Alzheimer's disease.

Human capital (HC) is increasingly important to corporate value creation. Unlike other assets, however, HC is not currently subject to well-defined measurement or disclosure rules. We use a machine learning algorithm (word2vec) trained on a confirmed set of HC disclosures to develop a comprehensive list of HC-related keywords classified into five subcategories (DEI; health and safety; labor relations and culture; compensation and benefits; and demographics and other) that capture the multidimensional nature of HC management. We share our lexicon, corporate HC disclosures, and the Python code used to develop the lexicon, and we provide detailed examples of using our data and code, including for fine-tuning a BERT model. Researchers can use our HC lexicon (or modify the code to capture another construct of interest) with their samples of corporate communications to address pertinent HC questions. We close with a discussion of future research opportunities related to HC management and disclosure.

This research implements an advanced unsupervised clustering system for MNIST handwritten digits through two-phase deep autoencoder architecture. A deep neural autoencoder requires a training process during phase one to develop minimal yet interpretive representations of images by minimizing reconstruction errors. During the second phase we unify the reconstruction error with a KMeans clustering loss for learned latent embeddings through a joint distance-based objective. Our model contains three elements which include batch normalization combined with dropout and weight decay for achieving generalized and stable results. The framework achieves superior clustering performance during extensive tests which used intrinsic measurements including Silhouette Score and Davies-Bouldin Index coupled with extrinsic metrics NMI and ARI when processing image features. The research uses t-SNE visualization to present learned embeddings that show distinct clusters for digits. Our approach reaches an optimal combination between data reconstruction accuracy and cluster separation purity when adding the benefit of understandable results and scalable implementations. The approach creates a dependable base that helps deploy unsupervised representation learning in different large-scale image clustering applications.

Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present scSSL-Bench, a comprehensive benchmark that evaluates nineteen SSL methods. Our evaluation spans nine datasets and focuses on three common downstream tasks: batch correction, cell type annotation, and missing modality prediction. Furthermore, we systematically assess various data augmentation strategies. Our analysis reveals task-specific trade-offs: the specialized single-cell frameworks, scVI, CLAIRE, and the finetuned scGPT excel at uni-modal batch correction, while generic SSL methods, such as VICReg and SimCLR, demonstrate superior performance in cell typing and multi-modal data integration. Random masking emerges as the most effective augmentation technique across all tasks, surpassing domain-specific augmentations. Notably, our results indicate the need for a specialized single-cell multi-modal data integration framework. scSSL-Bench provides a standardized evaluation platform and concrete recommendations for applying SSL to single-cell analysis, advancing the convergence of deep learning and single-cell genomics.

Stock price prediction remains a complex and high-stakes task in financial analysis, traditionally addressed using statistical models or, more recently, language models. In this work, we introduce VISTA (Vision-Language Inference for Stock Time-series Analysis), a novel, training-free framework that leverages Vision-Language Models (VLMs) for multi-modal stock forecasting. VISTA prompts a VLM with both textual representations of historical stock prices and their corresponding line charts to predict future price values. By combining numerical and visual modalities in a zero-shot setting and using carefully designed chain-of-thought prompts, VISTA captures complementary patterns that unimodal approaches often miss. We benchmark VISTA against standard baselines, including ARIMA and text-only LLM-based prompting methods. Experimental results show that VISTA outperforms these baselines by up to 89.83%, demonstrating the effectiveness of multi-modal inference for stock time-series analysis and highlighting the potential of VLMs in financial forecasting tasks without requiring task-specific training.

The self-attention mechanism, a cornerstone of Transformer-based state-of-the-art deep learning architectures, is largely heuristic-driven and fundamentally challenging to interpret. Establishing a robust theoretical foundation to explain its remarkable success and limitations has therefore become an increasingly prominent focus in recent research. Some notable directions have explored understanding self-attention through the lens of image denoising and nonparametric regression. While promising, existing frameworks still lack a deeper mechanistic interpretation of various architectural components that enhance self-attention, both in its original formulation and subsequent variants. In this work, we aim to advance this understanding by developing a unifying image processing framework, capable of explaining not only the self-attention computation itself but also the role of components such as positional encoding and residual connections, including numerous later variants. We also pinpoint potential distinctions between the two concepts building upon our framework, and make effort to close this gap. We introduce two independent architectural modifications within transformers. While our primary objective is interpretability, we empirically observe that image processing-inspired modifications can also lead to notably improved accuracy and robustness against data contamination and adversaries across language and vision tasks as well as better long sequence understanding.

Training deep learning networks with minimal supervision has gained significant research attention due to its potential to reduce reliance on extensive labelled data. While self-training methods have proven effective in semi-supervised learning, they remain vulnerable to errors from noisy pseudo labels. Moreover, most recent approaches to the few-label classification problem are either designed for resource-rich languages such as English or involve complex cascading models that are prone to overfitting. To address the persistent challenge of few-label text classification in truly low-resource linguistic contexts, where existing methods often struggle with noisy pseudo-labels and domain adaptation, we propose Flick. Unlike prior methods that rely on generic multi-cluster pseudo-labelling or complex cascading architectures, Flick leverages the fundamental insight that distilling high-confidence pseudo-labels from a broader set of initial clusters can dramatically improve pseudo-label quality, particularly for linguistically diverse, low-resource settings. Flick introduces a novel pseudo-label refinement component, a departure from traditional pseudo-labelling strategies by identifying and leveraging top-performing pseudo-label clusters. This component specifically learns to distil highly reliable pseudo-labels from an initial broad set by focusing on single-cluster cohesion and leveraging an adaptive top-k selection mechanism. This targeted refinement process is crucial for mitigating the propagation of errors inherent in low-resource data, allowing for robust fine-tuning of pre-trained language models with only a handful of true labels. We demonstrate Flick's efficacy across 14 diverse datasets, encompassing challenging low-resource languages such as Arabic, Urdu, and Setswana, alongside English, showcasing its superior performance and adaptability.

Gradient-based data influence approximation has been leveraged to select useful data samples in the supervised fine-tuning of large language models. However, the computation of gradients throughout the fine-tuning process requires too many resources to be feasible in practice. In this paper, we propose an efficient gradient-based data selection framework with clustering and a modified Upper Confidence Bound (UCB) algorithm. Based on the intuition that data samples with similar gradient features will have similar influences, we first perform clustering on the training data pool. Then, we frame the inter-cluster data selection as a constrained computing budget allocation problem and consider it a multi-armed bandit problem. A modified UCB algorithm is leveraged to solve this problem. Specifically, during the iterative sampling process, historical data influence information is recorded to directly estimate the distributions of each cluster, and a cold start is adopted to balance exploration and exploitation. Experimental results on various benchmarks show that our proposed framework, ClusterUCB, can achieve comparable results to the original gradient-based data selection methods while greatly reducing computing consumption.

--We present a method for fine-grained control over music generation through inference-time interventions on an autoregressive generative music transformer called MusicGen. Our approach enables timbre transfer, style transfer, and genre fusion by steering the residual stream using weights of linear probes trained on it, or by steering the attention layer activations in a similar manner . We observe that modelling this as a regression task provides improved performance, hypothesizing that the mean-squared-error better preserve meaningful directional information in the activation space. Combined with the global conditioning offered by text prompts in MusicGen, our method provides both global and local control over music generation. Audio samples illustrating our method are available at our demo page.

Real-world observational data often contain existing or emerging heterogeneous subpopulations that deviate from global patterns. The majority of models tend to overlook these underrepresented groups, leading to inaccurate or even harmful predictions. Existing solutions often rely on detecting these samples as Out-of-domain (OOD) rather than adapting the model to new emerging patterns. We introduce DynaSubVAE, a Dynamic Subgrouping Variational Autoencoder framework that jointly performs representation learning and adaptive OOD detection. Unlike conventional approaches, DynaSubVAE evolves with the data by dynamically updating its latent structure to capture new trends. It leverages a novel non-parametric clustering mechanism, inspired by Gaussian Mixture Models, to discover and model latent subgroups based on embedding similarity. Extensive experiments show that DynaSubVAE achieves competitive performance in both near-OOD and far-OOD detection, and excels in class-OOD scenarios where an entire class is missing during training. We further illustrate that our dynamic subgrouping mechanism outperforms standalone clustering methods such as GMM and KMeans++ in terms of both OOD accuracy and regret precision.