Inconsistencies between clinical and omics data may arise within medical cohorts. The identification, annotation and explanation of anomalous omics-based patients or individuals may become crucial to better reshape the disease, e.g., by detecting early onsets signaled by the omics and undetectable from observable symptoms. Here, we developed MLASDO (Machine Learning based Anomalous Sample Detection on Omics), a new method and software tool to identify, characterize and automatically describe anomalous samples based on omics data. Its workflow is based on three steps: (1) classification of healthy and cases individuals using a support vector machine algorithm; (2) detection of anomalous samples within groups; (3) explanation of anomalous individuals based on clinical data and expert knowledge. We showcase MLASDO using transcriptomics data of 317 healthy controls (HC) and 465 Parkinson's disease (PD) cases from the Parkinson's Progression Markers Initiative. In this cohort, MLASDO detected 15 anomalous HC with a PD-like transcriptomic signature and PD-like clinical features, including a lower proportion of CD4/CD8 naive T-cells and CD4 memory T-cells compared to HC (P<3.5*10^-3). MLASDO also identified 22 anomalous PD cases with a transcriptomic signature more similar to that of HC and some clinical features more similar to HC, including a lower proportion of mature neutrophils compared to PD cases (P<6*10^-3). In summary, MLASDO is a powerful tool that can help the clinician to detect and explain anomalous HC and cases of interest to be followed up. MLASDO is an open-source R package available at: https://github.com/JoseAdrian3/MLASDO.

This paper studies causal discovery in irregularly sampled time series-a pivotal challenge in high-stakes domains like finance, healthcare, and climate science, where missing data and inconsistent sampling frequencies distort causal mechanisms. Traditional methods (e.g., Granger causality, PCMCI) fail to reconcile multi-scale interactions (e.g., hourly storms vs. decadal climate shifts), while neural approaches (e.g., CUTS+) lack interpretability, stemming from a critical gap: existing frameworks either rigidly assume temporal regularity or aggregate dynamics into opaque representations, neglecting real-world granularity and auditable logic. To bridge this gap, we propose ReTimeCausal, a novel integration of Additive Noise Models (ANM) and Expectation-Maximization (EM) that unifies physics-guided data imputation with sparse causal inference. Through kernelized sparse regression and structural constraints, ReTimeCausal iteratively refines missing values (E-step) and causal graphs (M-step), resolving cross-frequency dependencies and missing data issues. Extensive experiments on synthetic and real-world datasets demonstrate that ReTimeCausal outperforms existing state-of-the-art methods under challenging irregular sampling and missing data conditions.

The discovery of new ionizable lipids for efficient lipid nanoparticle (LNP)-mediated RNA delivery remains a critical bottleneck for RNA-based therapeutics development. Recent advances have highlighted the potential of machine learning (ML) to predict transfection efficiency from molecular structure, enabling high-throughput virtual screening and accelerating lead identification. However, existing approaches are hindered by inadequate data quality, ineffective feature representations, low predictive accuracy, and poor generalizability. Here, we present LANTERN (Lipid nANoparticle Transfection Efficiency pRedictioN), a robust ML framework for predicting transfection efficiency based on ionizable lipid representation. We benchmarked a diverse set of ML models against AGILE, a previously published model developed for transfection prediction. Our results show that combining simpler models with chemically informative features, particularly count-based Morgan fingerprints, outperforms more complex models that rely on internally learned embeddings, such as AGILE. We also show that a multi-layer perceptron trained on a combination of Morgan fingerprints and Expert descriptors achieved the highest performance ($\text{R}^2$ = 0.8161, r = 0.9053), significantly exceeding AGILE ($\text{R}^2$ = 0.2655, r = 0.5488). We show that the models in LANTERN consistently have strong performance across multiple evaluation metrics. Thus, LANTERN offers a robust benchmarking framework for LNP transfection prediction and serves as a valuable tool for accelerating lipid-based RNA delivery systems design.

--Privacy policy documents are often lengthy, complex, and difficult for non-expert users to interpret, leading to a lack of transparency regarding the collection, processing, and sharing of personal data. As concerns over online privacy grow, it is essential to develop automated tools capable of analyzing privacy policies and identifying potential risks. In this study, we explore the potential of interactive graph visualizations to enhance user understanding of privacy policies by representing policy terms as structured graph models. This approach makes complex relationships more accessible and enables users to make informed decisions about their personal data (RQ1). We also employ graph mining algorithms to identify key themes, such as User Activity and Device Information, using dimensionality reduction techniques like t-SNE and PCA to assess clustering effectiveness. Our findings reveal that graph-based clustering improves policy content interpretability. It highlights patterns in user tracking and data sharing, which supports forensic investigations and identifies regulatory non-compliance.

Transfer learning has become an essential paradigm in artificial intelligence, enabling the transfer of knowledge from a source task to improve performance on a target task. This approach, particularly through techniques such as pretraining and fine-tuning, has seen significant success in fields like computer vision and natural language processing. However, despite its widespread use, how to reliably assess the transferability of knowledge remains a challenge. Understanding the theoretical underpinnings of each transferability metric is critical for ensuring the success of transfer learning. In this survey, we provide a unified taxonomy of transferability metrics, categorizing them based on transferable knowledge types and measurement granularity. This work examines the various metrics developed to evaluate the potential of source knowledge for transfer learning and their applicability across different learning paradigms emphasizing the need for careful selection of these metrics. By offering insights into how different metrics work under varying conditions, this survey aims to guide researchers and practitioners in selecting the most appropriate metric for specific applications, contributing to more efficient, reliable, and trustworthy AI systems. Finally, we discuss some open challenges in this field and propose future research directions to further advance the application of transferability metrics in trustworthy transfer learning.

This research investigates the efficacy of machine learning (ML) and deep learning (DL) methods in detecting misclassified intersection-related crashes in police-reported narratives. Using 2019 crash data from the Iowa Department of Transportation, we implemented and compared a comprehensive set of models, including Support Vector Machine (SVM), XGBoost, BERT Sentence Embeddings, BERT Word Embeddings, and Albert Model. Model performance was systematically validated against expert reviews of potentially misclassified narratives, providing a rigorous assessment of classification accuracy. Results demonstrated that while traditional ML methods exhibited superior overall performance compared to some DL approaches, the Albert Model achieved the highest agreement with expert classifications (73% with Expert 1) and original tabular data (58%). Statistical analysis revealed that the Albert Model maintained performance levels similar to inter-expert consistency rates, significantly outperforming other approaches, particularly on ambiguous narratives. This work addresses a critical gap in transportation safety research through multi-modal integration analysis, which achieved a 54.2% reduction in error rates by combining narrative text with structured crash data. We conclude that hybrid approaches combining automated classification with targeted expert review offer a practical methodology for improving crash data quality, with substantial implications for transportation safety management and policy development.

For years, semantic interoperability standards have sought to streamline the exchange of clinical data, yet their deployment remains time-consuming, resource-intensive, and technically challenging. To address this, we introduce a semi-automated approach that leverages large language models specifically GPT-4o and Llama 3.2 405b to convert structured clinical datasets into HL7 FHIR format while assessing accuracy, reliability, and security. Applying our method to the MIMIC-IV database, we combined embedding techniques, clustering algorithms, and semantic retrieval to craft prompts that guide the models in mapping each tabular field to its corresponding FHIR resource. In an initial benchmark, resource identification achieved a perfect F1-score, with GPT-4o outperforming Llama 3.2 thanks to the inclusion of FHIR resource schemas within the prompt. Under real-world conditions, accuracy dipped slightly to 94 %, but refinements to the prompting strategy restored robust mappings. Error analysis revealed occasional hallucinations of non-existent attributes and mismatches in granularity, which more detailed prompts can mitigate. Overall, our study demonstrates the feasibility of context-aware, LLM-driven transformation of clinical data into HL7 FHIR, laying the groundwork for semi-automated interoperability workflows. Future work will focus on fine-tuning models with specialized medical corpora, extending support to additional standards such as HL7 CDA and OMOP, and developing an interactive interface to enable expert validation and iterative refinement.

Sudden Death Syndrome (SDS), caused by Fusarium virguliforme, poses a significant threat to soybean production. This study presents an AI-driven web application for early detection of SDS on soybean leaves using hyperspectral imaging, enabling diagnosis prior to visible symptom onset. Leaf samples from healthy and inoculated plants were scanned using a portable hyperspectral imaging system (398-1011 nm), and a Genetic Algorithm was employed to select five informative wavelengths (505.4, 563.7, 712.2, 812.9, and 908.4 nm) critical for discriminating infection status. These selected bands were fed into a lightweight Convolutional Neural Network (CNN) to extract spatial-spectral features, which were subsequently classified using ten classical machine learning models. Ensemble classifiers (Random Forest, AdaBoost), Linear SVM, and Neural Net achieved the highest accuracy (>98%) and minimal error across all folds, as confirmed by confusion matrices and cross-validation metrics. Poor performance by Gaussian Process and QDA highlighted their unsuitability for this dataset. The trained models were deployed within a web application that enables users to upload hyperspectral leaf images, visualize spectral profiles, and receive real-time classification results. This system supports rapid and accessible plant disease diagnostics, contributing to precision agriculture practices. Future work will expand the training dataset to encompass diverse genotypes, field conditions, and disease stages, and will extend the system for multiclass disease classification and broader crop applicability.

Cross-domain recommendation (CDR) aims to address the persistent cold-start problem in Recommender Systems. Current CDR research concentrates on transferring cold-start users' information from the auxiliary domain to the target domain. However, these systems face two main issues: the underutilization of multimodal data, which hinders effective cross-domain alignment, and the neglect of side users who interact solely within the target domain, leading to inadequate learning of the target domain's vector space distribution. To address these issues, we propose a model leveraging Multimodal data and Side users for diffusion Cross-domain recommendation (MuSiC). We first employ a multimodal large language model to extract item multimodal features and leverage a large language model to uncover user features using prompt learning without fine-tuning. Secondly, we propose the cross-domain diffusion module to learn the generation of feature vectors in the target domain. This approach involves learning feature distribution from side users and understanding the patterns in cross-domain transformation through overlapping users. Subsequently, the trained diffusion module is used to generate feature vectors for cold-start users in the target domain, enabling the completion of cross-domain recommendation tasks. Finally, our experimental evaluation of the Amazon dataset confirms that MuSiC achieves state-of-the-art performance, significantly outperforming all selected baselines. Our code is available: https://anonymous.4open.science/r/MuSiC-310A/.

Federated learning with differential privacy suffers from two major costs: each client must transmit $d$-dimensional gradients every round, and the magnitude of DP noise grows with $d$. Yet empirical studies show that gradient updates exhibit strong temporal correlations and lie in a $k$-dimensional subspace with $k \ll d$. Motivated by this, we introduce DOME, a decentralized DP optimization framework in which each client maintains a compact sketch to project gradients into $\mathbb{R}^k$ before privatization and Secure Aggregation. This reduces per-round communication from order $d$ to order $k$ and moves towards a gradient approximation mean-squared error of $σ^2 k$. To allow the sketch to span new directions and prevent it from collapsing onto historical gradients, we augment it with random probes orthogonal to historical directions. We prove that our overall protocol satisfies $(ε,δ)$-Differential Privacy.