Radiation response in cancer is shaped by complex, patient specific biology, yet current treatment strategies often rely on uniform dose prescriptions without accounting for tumor heterogeneity. In this study, we introduce a meta learning framework for one-shot prediction of radiosensitivity measured by SF2 using cell line level gene expression data. Unlike the widely used Radiosensitivity Index RSI a rank-based linear model trained on a fixed 10-gene signature, our proposed meta-learned model allows the importance of each gene to vary by sample through fine tuning. This flexibility addresses key limitations of static models like RSI, which assume uniform gene contributions across tumor types and discard expression magnitude and gene gene interactions. Our results show that meta learning offers robust generalization to unseen samples and performs well in tumor subgroups with high radiosensitivity variability, such as adenocarcinoma and large cell carcinoma. By learning transferable structure across tasks while preserving sample specific adaptability, our approach enables rapid adaptation to individual samples, improving predictive accuracy across diverse tumor subtypes while uncovering context dependent patterns of gene influence that may inform personalized therapy.

Federated Learning (FL) is an emerging learning framework that enables edge devices to collaboratively train ML models without sharing their local data. FL faces, however, a significant challenge due to the high amount of information that must be exchanged between the devices and the aggregator in the training phase, which can exceed the limited capacity of wireless systems. In this paper, two communication-efficient FL methods are considered where communication overhead is reduced by communicating scalar values instead of long vectors and by allowing high number of users to send information simultaneously. The first approach employs a zero-order optimization technique with two-point gradient estimator, while the second involves a first-order gradient computation strategy. The novelty lies in leveraging channel information in the learning algorithms, eliminating hence the need for additional resources to acquire channel state information (CSI) and to remove its impact, as well as in considering asynchronous devices. We provide a rigorous analytical framework for the two methods, deriving convergence guarantees and establishing appropriate performance bounds.

Clustering algorithms often assume all features contribute equally to the data structure, an assumption that usually fails in high-dimensional or noisy settings. Feature weighting methods can address this, but most require additional parameter tuning. We propose SHARK (Shapley Reweighted $k$-means), a feature-weighted clustering algorithm motivated by the use of Shapley values from cooperative game theory to quantify feature relevance, which requires no additional parameters beyond those in $k$-means. We prove that the $k$-means objective can be decomposed into a sum of per-feature Shapley values, providing an axiomatic foundation for unsupervised feature relevance and reducing Shapley computation from exponential to polynomial time. SHARK iteratively re-weights features by the inverse of their Shapley contribution, emphasising informative dimensions and down-weighting irrelevant ones. Experiments on synthetic and real-world data sets show that SHARK consistently matches or outperforms existing methods, achieving superior robustness and accuracy, particularly in scenarios where noise may be present. Software: https://github.com/rickfawley/shark.

Time series forecasting poses significant challenges in non-stationary environments where underlying patterns evolve over time. In this work, we propose a novel framework that enhances deep neural network (DNN) performance by leveraging specialized model adaptation and selection. Initially, a base DNN is trained offline on historical time series data. A reserved validation subset is then segmented to extract and cluster the most dominant patterns within the series, thereby identifying distinct regimes. For each identified cluster, the base DNN is fine-tuned to produce a specialized version that captures unique pattern characteristics. At inference, the most recent input is matched against the cluster centroids, and the corresponding fine-tuned version is deployed based on the closest similarity measure. Additionally, our approach integrates a concept drift detection mechanism to identify and adapt to emerging patterns caused by non-stationary behavior. The proposed framework is generalizable across various DNN architectures and has demonstrated significant performance gains on both traditional DNNs and recent advanced architectures implemented in the GluonTS library.

Invasive ductal carcinoma (IDC) is the most prevalent form of breast cancer, and early, accurate diagnosis is critical to improving patient survival rates by guiding treatment decisions. Combining medical expertise with artificial intelligence (AI) holds significant promise for enhancing the precision and efficiency of IDC detection. In this work, we propose a human-in-the-loop (HITL) deep learning system designed to detect IDC in histopathology images. The system begins with an initial diagnosis provided by a high-performance EfficientNetV2S model, offering feedback from AI to the human expert. Medical professionals then review the AI-generated results, correct any misclassified images, and integrate the revised labels into the training dataset, forming a feedback loop from the human back to the AI. This iterative process refines the model's performance over time. The EfficientNetV2S model itself achieves state-of-the-art performance compared to existing methods in the literature, with an overall accuracy of 93.65\%. Incorporating the human-in-the-loop system further improves the model's accuracy using four experimental groups with misclassified images. These results demonstrate the potential of this collaborative approach to enhance AI performance in diagnostic systems. This work contributes to advancing automated, efficient, and highly accurate methods for IDC detection through human-AI collaboration, offering a promising direction for future AI-assisted medical diagnostics.

Federated unlearning (FU) algorithms allow clients in federated settings to exercise their ''right to be forgotten'' by removing the influence of their data from a collaboratively trained model. Existing FU methods maintain data privacy by performing unlearning locally on the client-side and sending targeted updates to the server without exposing forgotten data; yet they often rely on server-side cooperation, revealing the client's intent and identity without enforcement guarantees - compromising autonomy and unlearning privacy. In this work, we propose EFU (Enforced Federated Unlearning), a cryptographically enforced FU framework that enables clients to initiate unlearning while concealing its occurrence from the server. Specifically, EFU leverages functional encryption to bind encrypted updates to specific aggregation functions, ensuring the server can neither perform unauthorized computations nor detect or skip unlearning requests. To further mask behavioral and parameter shifts in the aggregated model, we incorporate auxiliary unlearning losses based on adversarial examples and parameter importance regularization. Extensive experiments show that EFU achieves near-random accuracy on forgotten data while maintaining performance comparable to full retraining across datasets and neural architectures - all while concealing unlearning intent from the server. Furthermore, we demonstrate that EFU is agnostic to the underlying unlearning algorithm, enabling secure, function-hiding, and verifiable unlearning for any client-side FU mechanism that issues targeted updates.

Active Infrared thermography (AIRT) is a widely adopted non-destructive testing (NDT) technique for detecting subsurface anomalies in industrial components. Due to the high dimensionality of AIRT data, current approaches employ non-linear autoencoders (AEs) for dimensionality reduction. However, the latent space learned by AIRT AEs lacks structure, limiting their effectiveness in downstream defect characterization tasks. To address this limitation, this paper proposes a principal component analysis guided (PCA-guided) autoencoding framework for structured dimensionality reduction to capture intricate, non-linear features in thermographic signals while enforcing a structured latent space. A novel loss function, PCA distillation loss, is introduced to guide AIRT AEs to align the latent representation with structured PCA components while capturing the intricate, non-linear patterns in thermographic signals. To evaluate the utility of the learned, structured latent space, we propose a neural network-based evaluation metric that assesses its suitability for defect characterization. Experimental results show that the proposed PCA-guided AE outperforms state-of-the-art dimensionality reduction methods on PVC, CFRP, and PLA samples in terms of contrast, signal-to-noise ratio (SNR), and neural network-based metrics.

The increasing demand for computational resources of training neural networks leads to a concerning growth in energy consumption. While parallelization has enabled upscaling model and dataset sizes and accelerated training, its impact on energy consumption is often overlooked. To close this research gap, we conducted scaling experiments for data-parallel training of two models, ResNet50 and FourCastNet, and evaluated the impact of parallelization parameters, i.e., GPU count, global batch size, and local batch size, on predictive performance, training time, and energy consumption. We show that energy consumption scales approximately linearly with the consumed resources, i.e., GPU hours; however, the respective scaling factor differs substantially between distinct model trainings and hardware, and is systematically influenced by the number of samples and gradient updates per GPU hour. Our results shed light on the complex interplay of scaling up neural network training and can inform future developments towards more sustainable AI research.

For transradial amputees, robotic prosthetic hands promise to regain the capability to perform daily living activities. To advance next-generation prosthetic hand control design, it is crucial to address current shortcomings in robustness to out of lab artifacts, and generalizability to new environments. Due to the fixed number of object to interact with in existing datasets, contrasted with the virtually infinite variety of objects encountered in the real world, current grasp models perform poorly on unseen objects, negatively affecting users' independence and quality of life. To address this: (i) we define semantic projection, the ability of a model to generalize to unseen object types and show that conventional models like YOLO, despite 80% training accuracy, drop to 15% on unseen objects. (ii) we propose Grasp-LLaVA, a Grasp Vision Language Model enabling human-like reasoning to infer the suitable grasp type estimate based on the object's physical characteristics resulting in a significant 50.2% accuracy over unseen object types compared to 36.7% accuracy of an SOTA grasp estimation model. Lastly, to bridge the performance-latency gap, we propose Hybrid Grasp Network (HGN), an edge-cloud deployment infrastructure enabling fast grasp estimation on edge and accurate cloud inference as a fail-safe, effectively expanding the latency vs. accuracy Pareto. HGN with confidence calibration (DC) enables dynamic switching between edge and cloud models, improving semantic projection accuracy by 5.6% (to 42.3%) with 3.5x speedup over the unseen object types. Over a real-world sample mix, it reaches 86% average accuracy (12.2% gain over edge-only), and 2.2x faster inference than Grasp-LLaVA alone.

The future of poultry production depends on a paradigm shift replacing subjective, labor-intensive welfare checks with data-driven, intelligent monitoring ecosystems. Traditional welfare assessments-limited by human observation and single-sensor data-cannot fully capture the complex, multidimensional nature of laying hen welfare in modern farms. Multimodal Artificial Intelligence (AI) offers a breakthrough, integrating visual, acoustic, environmental, and physiological data streams to reveal deeper insights into avian welfare dynamics. This investigation highlights multimodal As transformative potential, showing that intermediate (feature-level) fusion strategies achieve the best balance between robustness and performance under real-world poultry conditions, and offer greater scalability than early or late fusion approaches. Key adoption barriers include sensor fragility in harsh farm environments, high deployment costs, inconsistent behavioral definitions, and limited cross-farm generalizability. To address these, we introduce two novel evaluation tools - the Domain Transfer Score (DTS) to measure model adaptability across diverse farm settings, and the Data Reliability Index (DRI) to assess sensor data quality under operational constraints. We also propose a modular, context-aware deployment framework designed for laying hen environments, enabling scalable and practical integration of multimodal sensing. This work lays the foundation for a transition from reactive, unimodal monitoring to proactive, precision-driven welfare systems that unite productivity with ethical, science based animal care.