In this paper, we propose an approach to support the diagnosis of urinary tract diseases, with a focus on bladder cancer, using SHAP (SHapley Additive exPlanations)-based feature selection to enhance the transparency and effectiveness of predictive models. Six binary classification scenarios were developed to distinguish bladder cancer from other urological and oncological conditions. The algorithms XGBoost, LightGBM, and CatBoost were employed, with hyperparameter optimization performed using Optuna and class balancing with the SMOTE technique. The selection of predictive variables was guided by importance values through SHAP-based feature selection while maintaining or even improving performance metrics such as balanced accuracy, precision, and specificity. The use of explainability techniques (SHAP) for feature selection proved to be an effective approach. The proposed methodology may contribute to the development of more transparent, reliable, and efficient clinical decision support systems, optimizing screening and early diagnosis of urinary tract diseases.

Medical artificial intelligence systems have achieved remarkable diagnostic capabilities, yet they consistently exhibit performance disparities across demographic groups, causing real-world harm to underrepresented populations. While recent multimodal reasoning foundation models have advanced clinical diagnosis through integrated analysis of diverse medical data, reasoning trainings via reinforcement learning inherit and often amplify biases present in training datasets dominated by majority populations. We introduce Fairness-aware Group Relative Policy Optimization (FairGRPO), a hierarchical reinforcement learning approach that promotes equitable learning across heterogeneous clinical populations. FairGRPO employs adaptive importance weighting of advantages based on representation, task difficulty, and data source. To address the common issue of missing demographic labels in the clinical domain, we further employ unsupervised clustering, which automatically discovers latent demographic groups when labels are unavailable. Through comprehensive experiments across 7 clinical diagnostic datasets spanning 5 clinical modalities across X-ray, CT scan, dermoscropy, mammography and ultrasound, we demonstrate that FairGRPO reduces predictive parity by 27.2% against all vanilla and bias mitigated RL baselines, while improving F1 score by 12.49%. Furthermore, training dynamics analysis reveals that FairGRPO progressively improves fairness throughout optimization, while baseline RL methods exhibit deteriorating fairness as training progresses. Based on FairGRPO, we release FairMedGemma-4B, a fairness-aware clinical VLLM that achieves state-of-the-art performance while demonstrating significantly reduced disparities across demographic groups.

Counterfactual explanations (CFXs) provide human-understandable justifications for model predictions, enabling actionable recourse and enhancing interpretability. To be reliable, CFXs must avoid regions of high predictive uncertainty, where explanations may be misleading or inapplicable. However, existing methods often neglect uncertainty or lack principled mechanisms for incorporating it with formal guarantees. We propose CONFEX, a novel method for generating uncertainty-aware counterfactual explanations using Conformal Prediction (CP) and Mixed-Integer Linear Programming (MILP). CONFEX explanations are designed to provide local coverage guarantees, addressing the issue that CFX generation violates exchangeability. To do so, we develop a novel localised CP procedure that enjoys an efficient MILP encoding by leveraging an offline tree-based partitioning of the input space. This way, CONFEX generates CFXs with rigorous guarantees on both predictive uncertainty and optimality. We evaluate CONFEX against state-of-the-art methods across diverse benchmarks and metrics, demonstrating that our uncertainty-aware approach yields robust and plausible explanations.

Abstract--Federated Learning (FL) enables collaborative training of Machine Learning (ML) models across multiple clients while preserving their privacy. Rather than sharing raw data, federated clients transmit locally computed updates to train the global model. Although this paradigm should provide stronger privacy guarantees than centralized ML, client updates remain vulnerable to privacy leakage. Adversaries can exploit them to infer sensitive properties about the training data or even to reconstruct the original inputs via Gradient Inversion Attacks (GIAs). Under the honest-but-curious threat model, GIAs attempt to reconstruct training data by reversing intermediate updates using optimization-based techniques. We observe that these approaches usually reconstruct noisy approximations of the original inputs, whose quality can be enhanced with specialized denoising models. This paper presents Gradient Update Inversion with DEnoising (GUIDE), a novel methodology that leverages diffusion models as denoising tools to improve image reconstruction attacks in FL. GUIDE can be integrated into any GIAs that exploits surrogate datasets, a widely adopted assumption in GIAs literature. We comprehensively evaluate our approach in two attack scenarios that use different FL algorithms, models, and datasets. Our results demonstrate that GUIDE integrates seamlessly with two state-of-the-art GIAs, substantially improving reconstruction quality across multiple metrics. Specifically, GUIDE achieves up to 46% higher perceptual similarity, as measured by the DreamSim metric.

Multi-class wine classification presents fundamental trade-offs between model accuracy, feature dimensionality, and interpretability - critical factors for production deployment in analytical chemistry. This paper presents a comprehensive empirical study of One-vs-Rest logistic regression on the UCI Wine dataset (178 samples, 3 cultivars, 13 chemical features), comparing from-scratch gradient descent implementation against scikit-learn's optimized solvers and quantifying L1 regularization effects on feature sparsity. Manual gradient descent achieves 92.59 percent mean test accuracy with smooth convergence, validating theoretical foundations, though scikit-learn provides 24x training speedup and 98.15 percent accuracy. Class-specific analysis reveals distinct chemical signatures with heterogeneous patterns where color intensity varies dramatically (0.31 to 16.50) across cultivars. L1 regularization produces 54-69 percent feature reduction with only 4.63 percent accuracy decrease, demonstrating favorable interpretability-performance trade-offs. We propose an optimal 5-feature subset achieving 62 percent complexity reduction with estimated 92-94 percent accuracy, enabling cost-effective deployment with 80 dollars savings per sample and 56 percent time reduction. Statistical validation confirms robust generalization with sub-2ms prediction latency suitable for real-time quality control. Our findings provide actionable guidelines for practitioners balancing comprehensive chemical analysis against targeted feature measurement in resource-constrained environments.

Aging is a highly complex and heterogeneous process that progresses at different rates across individuals, making biological age (BA) a more accurate indicator of physiological decline than chronological age. While previous studies have built aging clocks using single-omics data, they often fail to capture the full molecular complexity of human aging. In this work, we leveraged the Human Phenotype Project, a large-scale cohort of 10,000 adults aged 40-70 years, with extensive longitudinal profiling that includes clinical, behavioral, environmental, and multi-omics datasets spanning transcriptomics, lipidomics, metabolomics, and the microbiome. By employing advanced machine learning frameworks capable of modeling nonlinear biological dynamics, we developed and rigorously validated a multi-omics aging clock that robustly predicts diverse health outcomes and future disease risk. Unsupervised clustering of the integrated molecular profiles from multi-omics uncovered distinct biological subtypes of aging, revealing striking heterogeneity in aging trajectories and pinpointing pathway-specific alterations associated with different aging patterns. These findings demonstrate the power of multi-omics integration to decode the molecular landscape of aging and lay the groundwork for personalized healthspan monitoring and precision strategies to prevent age-related diseases.

In recent years, large language models (LLMs) have made remarkable progress, with model optimization primarily relying on gradient-based optimizers such as Adam. However, these gradient-based methods impose stringent hardware requirements, demanding high-concurrency, high-memory GPUs. Moreover, they require all neural network operations to be differentiable, thereby excluding many promising non-differentiable architectures from practical use. To address these limitations, we propose EA4LLM, an evolutionary algorithm for optimizing LLMs, and, for the first time, empirically verify full-parameter optimization from the pretraining stage across model sizes ranging from 0.5B to 32B. We conduct extensive experiments and provide key insights into how evolutionary algorithms can effectively optimize neural networks. Our work challenges the prevailing assumption that gradient-based optimization is the only viable approach for training neural networks. It also holds significant potential to reduce the computational cost of training large language models, thereby enabling groups with limited computational resources to participate in deep learning research.

Developers consistently use version constraints to specify acceptable versions of the dependencies for their project. \emph{Pinning} dependencies can reduce the likelihood of breaking changes, but comes with a cost of manually managing the replacement of outdated and vulnerable dependencies. On the other hand, \emph{floating} can be used to automatically get bug fixes and security fixes, but comes with the risk of breaking changes. Security practitioners advocate \emph{pinning} dependencies to prevent against software supply chain attacks, e.g., malicious package updates. However, since \emph{pinning} is the tightest version constraint, \emph{pinning} is the most likely to result in outdated dependencies. Nevertheless, how the likelihood of becoming outdated or vulnerable dependencies changes across version constraint types is unknown. The goal of this study is to aid developers in making an informed dependency version constraint choice by empirically evaluating the likelihood of dependencies becoming outdated or vulnerable across version constraint types at scale. In this study, we first identify the trends in dependency version constraint usage and the patterns of version constraint type changes made by developers in the npm, PyPI, and Cargo ecosystems. We then modeled the dependency state transitions using survival analysis and estimated how the likelihood of becoming outdated or vulnerable changes when using \emph{pinning} as opposed to the rest of the version constraint types. We observe that among outdated and vulnerable dependencies, the most commonly used version constraint type is \emph{floating-minor}, with \emph{pinning} being the next most common. We also find that \emph{floating-major} is the least likely to result in outdated and \emph{floating-minor} is the least likely to result in vulnerable dependencies.

Softmax Attention has a quadratic time complexity, which becomes prohibitive to run at long contexts, even with highly optimized GPU kernels. For example, FlashAttention (an exact, GPU-optimized implementation of Softmax Attention) cannot complete a single forward-backward pass of a multi-head attention layer once the context exceeds ~4 million tokens on an NVIDIA GH200 (96 GB). We introduce RACE Attention, a kernel-inspired alternative to Softmax Attention that is linear in sequence length and embedding dimension. RACE Attention replaces the exponential kernel with a sharpened angular (cosine) similarity, and approximates attention outputs via randomized projections and soft Locality-Sensitive Hashing (LSH). Across language modeling, masked language modeling, and text classification, RACE Attention matches the accuracy of strong baselines while reducing runtime and memory. In a controlled scale test, it processes up to 12 million tokens during a single forward-backward pass on an NVIDIA GH200 GPU and 75 million tokens on an Intel Xeon Gold 5220R CPU, well beyond the practical limits of the current state-of-the-art attention implementations. RACE Attention thus offers a practical, theoretically grounded mechanism for outrageously long context windows on today's hardware. We hope that it gets adopted in practice.

Sensor-based sorting systems enable the physical separation of a material stream into two fractions. The sorting decision is based on the image data evaluation of the sensors used and is carried out using actuators. Various process parameters must be set depending on the properties of the material stream, the dimensioning of the system, and the required sorting accuracy. However, continuous verification and re-adjustment are necessary due to changing requirements and material stream compositions. In this paper, we introduce an approach for optimizing, recurrently monitoring and adjusting the process parameters of a sensor-based sorting system. Based on Bayesian Optimization, Gaussian process regression models are used as surrogate models to achieve specific requirements for system behavior with the uncertainties contained therein. This method minimizes the number of necessary experiments while simultaneously considering two possible optimization targets based on the requirements for both material output streams. In addition, uncertainties are considered during determining sorting accuracies in the model calculation. We evaluated the method with three example process parameters.