PROBAST: a tool to assess risk of bias and applicability of prediction model studies: explanation and elaboration.

In multiple-choice exams, students select one answer from among typically four choices and can explain why they made that particular choice. Students are good at understanding natural language questions and based on their domain knowledge can easily infer the question's answer by 'connecting the dots' across various pertinent facts. Considering automated reasoning for elementary science question answering, we address the novel task of generating explanations for answers from human-authored facts. For this, we examine the practically scalable framework of feature-rich support vector machines leveraging domain-targeted, hand-crafted features. Explanations are created from a human-annotated set of nearly 5,000 candidate facts in the WorldTree corpus. Our aim is to obtain better matches for valid facts of an explanation for the correct answer of a question over the available fact candidates. To this end, our features offer a comprehensive linguistic and semantic unification paradigm. The machine learning problem is the preference ordering of facts, for which we test pointwise regression versus pairwise learning-to-rank. Our contributions are: (1) a case study in which two preference ordering approaches are systematically compared; (2) it is a practically competent approach that can outperform some variants of BERT-based reranking models; and (3) the human-engineered features make it an interpretable machine learning model for the task.

Clinical characterization and interpretation of respiratory sound symptoms have remained a challenge due to the similarities in the audio properties that manifest during auscultation in medical diagnosis. The misinterpretation and conflation of these sounds coupled with the comorbidity cases of the associated ailments - particularly, exercised-induced respiratory conditions; result in the under-diagnosis and undertreatment of the conditions. Though several studies have proposed computerized systems for objective classification and evaluation of these sounds, most of the algorithms run on desktop and backend systems. In this study, we leverage the improved computational and storage capabilities of modern smartphones to distinguish the respiratory sound symptoms using machine learning algorithms namely: Random Forest (RF), Support Vector Machine (SVM), and k-Nearest Neighbour (k-NN). The appreciable performance of these classifiers on a mobile phone shows smartphone as an alternate tool for recognition and discrimination of respiratory symptoms in real-time scenarios. Further, the objective clinical data provided by the machine learning process could aid physicians in the screening and treatment of a patient during ambulatory care where specialized medical devices may not be readily available.

SVM is a powerful supervised algorithm that works best on smaller datasets but on complex ones. Support Vector Machine, abbreviated as SVM can be used for both regression and classification tasks, but generally, they work best in classification problems. They were very famous around the time they were created, during the 1990s, and keep on being the go-to method for a high-performing algorithm with a little tuning. By now, I hope you've now mastered Decision Trees, Random Forest, Naïve Bayes, K-nearest neighbor, and Ensemble Modelling techniques. If not, I would suggest you take out a few minutes and read about them as well. In this article, I will explain to you What is SVM, how SVM works, and the math intuition behind this crucial ML algorithm. It is a supervised machine learning problem where we try to find a hyperplane that best separates the two classes. Note: Don't get confused between SVM and logistic regression.

Concrete is the most commonly used material in civil engineering. That is why lots of research and experiments are done on concrete. In this experiment, it is tried to understand how the compressive strength will be according to the materials in the concrete. Concrete has many properties like shear strength, tensile strength. Compressive strength is one of the most important properties.

Surface roughness is primary measure of pavement performance that has been associated with ride quality and vehicle operating costs. Of all the surface roughness indicators, the International Roughness Index (IRI) is the most widely used. However, it is costly to measure IRI, and for this reason, certain road classes are excluded from IRI measurements at a network level. Higher levels of distresses are generally associated with higher roughness. However, for a given roughness level, pavement data typically exhibits a great deal of variability in the distress types, density, and severity. It is hypothesized that it is feasible to estimate the IRI of a pavement section given its distress types and their respective densities and severities. To investigate this hypothesis, this paper uses data from in-service pavements and machine learning methods to ascertain the extent to which IRI can be predicted given a set of pavement attributes. The results suggest that machine learning can be used reliably to estimate IRI based on the measured distress types and their respective densities and severities. The analysis also showed that IRI estimated this way depends on the pavement type and functional class. The paper also includes an exploratory section that addresses the reverse situation, that is, estimating the probability of pavement distress type distribution and occurrence severity/extent based on a given roughness level.

In contrast to single-objective optimization (SOO), multi-objective optimization (MOO) requires an optimizer to find the Pareto frontier, a subset of feasible solutions that are not dominated by other feasible solutions. In this paper, we propose LaMOO, a novel multi-objective optimizer that learns a model from observed samples to partition the search space and then focus on promising regions that are likely to contain a subset of the Pareto frontier. The partitioning is based on the dominance number, which measures "how close" a data point is to the Pareto frontier among existing samples. To account for possible partition errors due to limited samples and model mismatch, we leverage Monte Carlo Tree Search (MCTS) to exploit promising regions while exploring suboptimal regions that may turn out to contain good solutions later. Theoretically, we prove the efficacy of learning space partitioning via LaMOO under certain assumptions. Empirically, on the HyperVolume (HV) benchmark, a popular MOO metric, LaMOO substantially outperforms strong baselines on multiple real-world MOO tasks, by up to 225% in sample efficiency for neural architecture search on Nasbench201, and up to 10% for molecular design. Multi-objective optimization (MOO) has been extensively used in many practical scenarios involving trade-offs between multiple objectives. For example, in automobile design (Chang, 2015), we must maximize the performance of the engine while simultaneously minimizing emissions and fuel consumption.

Innovative technologies such as artificial intelligence (AI) machine learning and optogenetics are accelerating discoveries in life sciences, especially in the field of neuroscience. A new breakthrough study published in Current Biology by pioneering brain researchers at Vanderbilt University used optogenetics and AI machine learning to reveal that dopamine is not just a "pleasure molecule" -- a revolutionary finding that may impact how addiction and psychiatric diseases are treated in the future. "Dopamine deficits are seen in patients suffering from substance use disorder," said Erin Calipari, an assistant professor of pharmacology at Vanderbilt University, and faculty member of both the Vanderbilt Brain Institute and the Vanderbilt Center for Addiction Research. "These individuals have reduced dopamine as well as deficits in decision-making that would be explained by our data and new model. These deficits in decision-making are highly correlated with the severity of addiction as well as predicting treatment outcomes. These data are really key to understanding the relationship between dopamine this disease and figuring out how to treat it."

There are people who are eager to move to Analytics careers but do not have the requisite skill sets. As we move into our 12th year in the Analytics Industry, OrangeTree Global has designed specific courses for freshers and working professionals who are looking at moving to Data Science, Machine Learning and Big Data Careers. Since 2009, OrangeTree Global has embarked on an ambitious vision of providing affordable and effective Analytics Training and Education across the country. OrangeTree Global has over a decade's experience in upskilling professionals and helping them move to analytics jobs and careers within and outside India. If you are reading this, we hope to be a part of your journey too.The program builds a solid foundation by covering the most popular and widely used machine learning technologies and its applications, including Naive Bayes theory and application, K Nearest Neighbors (KNN) theory and application, Random forest theory and application, Gradient Boosting Theory and Application and also Support Vector Machine Theory and Application–laying the building blocks for truly expanded analytical abilities.

It is well-known that machine learning protocols typically under-utilize information on the probability distributions of feature vectors and related data, and instead directly compute regression or classification functions of feature vectors. In this paper we introduce a set of novel features for identifying underlying stochastic behavior of input data using the Karhunen-Lo\'{e}ve (KL) expansion, where classification is treated as detection of anomalies from a (nominal) signal class. These features are constructed from the recent Functional Data Analysis (FDA) theory for anomaly detection. The related signal decomposition is an exact hierarchical tensor product expansion with known optimality properties for approximating stochastic processes (random fields) with finite dimensional function spaces. In principle these primary low dimensional spaces can capture most of the stochastic behavior of `underlying signals' in a given nominal class, and can reject signals in alternative classes as stochastic anomalies. Using a hierarchical finite dimensional KL expansion of the nominal class, a series of orthogonal nested subspaces is constructed for detecting anomalous signal components. Projection coefficients of input data in these subspaces are then used to train an ML classifier. However, due to the split of the signal into nominal and anomalous projection components, clearer separation surfaces of the classes arise. In fact we show that with a sufficiently accurate estimation of the covariance structure of the nominal class, a sharp classification can be obtained. We carefully formulate this concept and demonstrate it on a number of high-dimensional datasets in cancer diagnostics. This method leads to a significant increase in precision and accuracy over the current top benchmarks for the Global Cancer Map (GCM) gene expression network dataset.