Protein Language Models (PLMs) have achieved significant breakthroughs in computational protein science through pre-training on large-scale sequence databases and leveraging scalable network architectures. Concurrently, Reinforcement Learning (RL) has demonstrated substantial progress across multiple protein design tasks by enabling expanded exploration capabilities and precise multi-objective optimization. While RL has shown transformative potential in natural language processing by enabling models to discover emergent capabilities beyond their training distributions, its capacity to unlock latent functional patterns within protein sequence space remains underexplored. In this study, we investigate whether RL-enhanced PLMs can transcend their pre-training limitations and identify implicit sequence-structure-function relationships not explicitly encoded in foundational datasets. Through systematic evaluation across four critical protein design domains--antimicrobial peptide (AMP) design, kinase optimization, antibody engineering, and inverse folding--we employ diverse RL algorithms and model architectures to address this fundamental question. Our comprehensive analysis demonstrates that RL reliably improves sampling efficiency across domains and, more importantly, that its effectiveness is governed by a three-factor interaction: task difficulty, reward model accuracy, and policy capacity. Gains scale when rewards are accurate and informative, policies have sufficient capacity to realize the signal, and tasks present headroom beyond supervised learning; conversely, noisy rewards or capacity bottlenecks cap improvements despite exploration. This principled view offers practical guidance for RL in protein design: prioritize reward refinement before scaling policy size, match RL algorithms and regularization strength to task difficulty, and allocate capacity where marginal gains are largest. Implementation is available at github. These advances have successfully propelled the development of sequence-function relationship studies and protein design applications (Qiu et al., 2024; Zhang et al., 2025; Ruffolo et al., 2025). Task difficulty equates to mountain height, policy model capacity to the starting altitude, and reward accuracy to direction correctness.

Diffusion language models (dLLMs) offer a promising, non-autoregressive paradigm for text generation, yet training them for complex reasoning remains a key challenge. Current reinforcement learning approaches often rely on sparse, outcome-based rewards, which can reinforce flawed reasoning paths that lead to coincidentally correct answers. We argue that this stems from a fundamental mismatch with the natural structure of reasoning. We first propose a theoretical framework that formalizes complex problem solving as a hierarchical selection process, where an intractable global constraint is decomposed into a series of simpler, localized logical steps. This framework provides a principled foundation for algorithm design, including theoretical insights into the identifiability of this latent reasoning structure. Motivated by this theory, we identify unstructured refinement -- a failure mode where a model's iterative steps do not contribute meaningfully to the solution -- as a core deficiency in existing methods. We then introduce Step-Aware Policy Optimization (SAPO), a novel RL algorithm that aligns the dLLM's denoising process with the latent reasoning hierarchy. By using a process-based reward function that encourages incremental progress, SAPO guides the model to learn structured, coherent reasoning paths. Our empirical results show that this principled approach significantly improves performance on challenging reasoning benchmarks and enhances the interpretability of the generation process.

Although current large Vision-Language Models (VLMs) have advanced in multimodal understanding and reasoning, their fundamental perceptual and reasoning abilities remain limited. Specifically, even on simple jigsaw tasks, existing VLMs perform near randomly, revealing deficiencies in core perception and reasoning capabilities. While high-quality vision-language data can enhance these capabilities, its scarcity and limited scalability impose significant constraints. To address this, we propose AGILE, an Agentic jiGsaw Interaction Learning for Enhancing visual perception and reasoning in VLMs. AGILE formulates jigsaw solving as an interactive process, enabling the model to progressively engage with the environment. At each step, the model generates executable code to perform an action based on the current state, while the environment provides fine-grained visual feedback to guide task completion. Through this iterative cycle of observation and interaction, the model incrementally improves its perceptual and reasoning capabilities via exploration and feedback. Experimental results show that AGILE not only substantially boosts performance on jigsaw tasks of varying complexity (e.g., increasing accuracy from 9.5% to 82.8% under the 2 $\times$ 2 setting) but also demonstrates strong generalization across 9 general vision tasks, achieving an average improvement of 3.1%. These results indicate notable enhancements in both perceptual and reasoning abilities. This work opens a new avenue for advancing reasoning and generalization in multimodal models and provides an efficient, scalable solution to the scarcity of multimodal reinforcement learning data. The code and datasets is available at https://github.com/yuzeng0-0/AGILE .

Accurate prediction of human behavior is essential for robust and safe human-AI collaboration. However, existing approaches for modeling people are often data-hungry and brittle because they either make unrealistic assumptions about rationality or are too computationally demanding to adapt rapidly. Our key insight is that many everyday social interactions may follow predictable patterns; efficient "scripts" that minimize cognitive load for actors and observers, e.g., "wait for the green light, then go." We propose modeling these routines as behavioral programs instantiated in computer code rather than policies conditioned on beliefs and desires. We introduce ROTE, a novel algorithm that leverages both large language models (LLMs) for synthesizing a hypothesis space of behavioral programs, and probabilistic inference for reasoning about uncertainty over that space. We test ROTE in a suite of gridworld tasks and a large-scale embodied household simulator. ROTE predicts human and AI behaviors from sparse observations, outperforming competitive baselines -- including behavior cloning and LLM-based methods -- by as much as 50% in terms of in-sample accuracy and out-of-sample generalization. By treating action understanding as a program synthesis problem, ROTE opens a path for AI systems to efficiently and effectively predict human behavior in the real-world.

The dominant paradigm for training large reasoning models starts with pre-training using next-token prediction loss on vast amounts of data. Reinforcement learning, while powerful in scaling reasoning, is introduced only as the very last phase of post-training, preceded by supervised fine-tuning. While dominant, is this an optimal way of training? In this paper, we present RLP, an information-driven reinforcement pretraining objective, that brings the core spirit of reinforcement learning -- exploration -- to the last phase of pretraining. The key idea is to treat chain-of-thought as an exploratory action, with rewards computed based on the information gain it provides for predicting future tokens. This training objective essentially encourages the model to think for itself before predicting what comes next, thus teaching an independent thinking behavior earlier in the pretraining. More concretely, the reward signal measures the increase in log-likelihood of the next token when conditioning on both context and a sampled reasoning chain, compared to conditioning on context alone. This approach yields a verifier-free dense reward signal, allowing for efficient training for the full document stream during pretraining. Specifically, RLP reframes reinforcement learning for reasoning as a pretraining objective on ordinary text, bridging the gap between next-token prediction and the emergence of useful chain-of-thought reasoning. Pretraining with RLP on Qwen3-1.7B-Base lifts the overall average across an eight-benchmark math-and-science suite by 19%. With identical post-training, the gains compound, with the largest improvements on reasoning-heavy tasks such as AIME25 and MMLU-Pro. Applying RLP to the hybrid Nemotron-Nano-12B-v2 increases the overall average from 42.81% to 61.32% and raises the average on scientific reasoning by 23%, demonstrating scalability across architectures and model sizes.

Federated learning is vulnerable to poisoning and backdoor attacks under partial observability. We formulate defence as a partially observable sequential decision problem and introduce a trust-aware Deep Q-Network that integrates multi-signal evidence into client trust updates while optimizing a long-horizon robustness--accuracy objective. On CIFAR-10, we (i) establish a baseline showing steadily improving accuracy, (ii) show through a Dirichlet sweep that increased client overlap consistently improves accuracy and reduces ASR with stable detection, and (iii) demonstrate in a signal-budget study that accuracy remains steady while ASR increases and ROC-AUC declines as observability is reduced, which highlights that sequential belief updates mitigate weaker signals. Finally, a comparison with random, linear-Q, and policy gradient controllers confirms that DQN achieves the best robustness--accuracy trade-off.

Autonomous navigation for mechanical thrombectomy (MT) remains a critical challenge due to the complexity of vascular anatomy and the need for precise, real-time decision-making. Reinforcement learning (RL)-based approaches have demonstrated potential in automating endovascular navigation, but current methods often struggle with generalization across multiple patient vasculatures and long-horizon tasks. We propose a world model for autonomous endovascular navigation using TD-MPC2, a model-based RL algorithm. We trained a single RL agent across multiple endovascular navigation tasks in ten real patient vasculatures, comparing performance against the state-of-the-art Soft Actor-Critic (SAC) method. Results indicate that TD-MPC2 significantly outperforms SAC in multi-task learning, achieving a 65% mean success rate compared to SAC's 37%, with notable improvements in path ratio. TD-MPC2 exhibited increased procedure times, suggesting a trade-off between success rate and execution speed. These findings highlight the potential of world models for improving autonomous endovascular navigation and lay the foundation for future research in generalizable AI-driven robotic interventions.

Learning control policies for multi-robot systems (MRS) remains a major challenge due to long-term coordination and the difficulty of obtaining realistic training data. In this work, we address both limitations within an imitation learning framework. First, we shift the typical role of Curriculum Learning in MRS, from scalability with the number of robots, to focus on improving long-term coordination. We propose a curriculum strategy that gradually increases the length of expert trajectories during training, stabilizing learning and enhancing the accuracy of long-term behaviors. Second, we introduce a method to approximate the egocentric perception of each robot using only third-person global state demonstrations. Our approach transforms idealized trajectories into locally available observations by filtering neighbors, converting reference frames, and simulating onboard sensor variability. Both contributions are integrated into a physics-informed technique to produce scalable, distributed policies from observations. We conduct experiments across two tasks with varying team sizes and noise levels. Results show that our curriculum improves long-term accuracy, while our perceptual estimation method yields policies that are robust to realistic uncertainty. Together, these strategies enable the learning of robust, distributed controllers from global demonstrations, even in the absence of expert actions or onboard measurements.

Multi-Agent Reinforcement Learning (MARL) provides a powerful framework for learning coordination in multi-agent systems. However, applying MARL to robotics still remains challenging due to high-dimensional continuous joint action spaces, complex reward design, and non-stationary transitions inherent to decentralized settings. On the other hand, humans learn complex coordination through staged curricula, where long-horizon behaviors are progressively built upon simpler skills. Motivated by this, we propose CRAFT: Coaching Reinforcement learning Autonomously using Foundation models for multi-robot coordination Tasks, a framework that leverages the reasoning capabilities of foundation models to act as a "coach" for multi-robot coordination. CRAFT automatically decomposes long-horizon coordination tasks into sequences of subtasks using the planning capability of Large Language Models (LLMs). In what follows, CRAFT trains each subtask using reward functions generated by LLM, and refines them through a Vision Language Model (VLM)-guided reward-refinement loop. We evaluate CRAFT on multi-quadruped navigation and bimanual manipulation tasks, demonstrating its capability to learn complex coordination behaviors. In addition, we validate the multi-quadruped navigation policy in real hardware experiments.

First provide a summary of the paper, and then address the following criteria: Quality, clarity, originality and significance. In their paper "Information-based learning by agents in unbounded state spaces" the authors extend a previous model of information-based exploration as described in reference [11] to unbounded state spaces by introducing a Chinese restaurant process to model transition probabilities. Previous studies have used the Chinese restaurant process for reinforcement learning--for example, reference [2] cited by the authors. It would therefore be good if the authors could clarify the differences to previous studies that have used Chinese restaurant processes in reinforcement learning to clarify originality. L 130: verb is missing in the second part of the sentence To compute the information gain the authors need to compute relative entropies between the true state transition distribution and the estimated state transition distribution.