Designing RNA molecules has garnered recent interest in medicine, synthetic biology, biotechnology and bioinformatics since many functional RNA molecules were shown to be involved in regulatory processes for transcription, epigenetics and translation. Since an RNA's function depends on its structural properties, the RNA Design problem is to find an RNA sequence that folds into a specified secondary structure. Here, we propose a new algorithm for the RNA Design problem, dubbed LEARNA. LEARNA uses deep reinforcement learning to train a policy network to sequentially design an entire RNA sequence given a specified secondary target structure. By meta-learning across 8000 different RNA target structures for one hour on 20 cores, our extension Meta-LEARNA constructs an RNA Design policy that can be applied out of the box to solve novel RNA target structures. Methodologically, for what we believe to be the first time, we jointly optimize over a rich space of neural architectures for the policy network, the hyperparameters of the training procedure and the formulation of the decision process. Comprehensive empirical results on two widely-used RNA secondary structure design benchmarks, as well as a third one that we introduce, show that our approach achieves new state-of-the-art performance on all benchmarks while also being orders of magnitudes faster in reaching the previous state-of-the-art performance. In an ablation study, we analyze the importance of our method's different components.

We propose a practical non-episodic PSRL algorithm that unlike recent state-of-the-art PSRL algorithms uses a deterministic, model-independent episode switching schedule. Our algorithm termed deterministic schedule PSRL (DS-PSRL) is efficient in terms of time, sample, and space complexity. We prove a Bayesian regret bound under mild assumptions. Our result is more generally applicable to multiple parameters and continuous state action problems. We compare our algorithm with state-of-the-art PSRL algorithms on standard discrete and continuous problems from the literature. Finally, we show how the assumptions of our algorithm satisfy a sensible parameterization for a large class of problems in sequential recommendations.

We consider the off-policy estimation problem of estimating the expected reward of a target policy using samples collected by a different behavior policy. Importance sampling (IS) has been a key technique to derive (nearly) unbiased estimators, but is known to suffer from an excessively high variance in long-horizon problems. In the extreme case of in infinite-horizon problems, the variance of an IS-based estimator may even be unbounded. In this paper, we propose a new off-policy estimation method that applies IS directly on the stationary state-visitation distributions to avoid the exploding variance issue faced by existing estimators.Our key contribution is a novel approach to estimating the density ratio of two stationary distributions, with trajectories sampled from only the behavior distribution. We develop a mini-max loss function for the estimation problem, and derive a closed-form solution for the case of RKHS. We support our method with both theoretical and empirical analyses.

One of the ultimate promises of computer vision is to help robotic agents perform active tasks, like delivering packages or doing household chores. However, the conventional approach to solving "vision" is to define a set of offline recognition problems (e.g. object detection) and solve those first. This approach faces a challenge from the recent rise of Deep Reinforcement Learning frameworks that learn active tasks from scratch using images as input. This poses a set of fundamental questions: what is the role of computer vision if everything can be learned from scratch? Could intermediate vision tasks actually be useful for performing arbitrary downstream active tasks? We show that proper use of mid-level perception confers significant advantages over training from scratch. We implement a perception module as a set of mid-level visual representations and demonstrate that learning active tasks with mid-level features is significantly more sample-efficient than scratch and able to generalize in situations where the from-scratch approach fails. However, we show that realizing these gains requires careful selection of the particular mid-level features for each downstream task. Finally, we put forth a simple and efficient perception module based on the results of our study, which can be adopted as a rather generic perception module for active frameworks.

We consider a team of reinforcement learning agents that concurrently operate in a common environment, and we develop an approach to efficient coordinated exploration that is suitable for problems of practical scale. Our approach builds on the seed sampling concept introduced in Dimakopoulou and Van Roy (2018) and on a randomized value function learning algorithm from Osband et al. (2016). We demonstrate that, for simple tabular contexts, the approach is competitive with those previously proposed in Dimakopoulou and Van Roy (2018) and with a higher-dimensional problem and a neural network value function representation, the approach learns quickly with far fewer agents than alternative exploration schemes.

The accurate exposure is the key of capturing high-quality photos in computational photography, especially for mobile phones that are limited by sizes of camera modules. Inspired by luminosity masks usually applied by professional photographers, in this paper, we develop a novel algorithm for learning local exposures with deep reinforcement adversarial learning. To be specific, we segment an image into sub-images that can reflect variations of dynamic range exposures according to raw low-level features. Based on these sub-images, a local exposure for each sub-image is automatically learned by virtue of policy network sequentially while the reward of learning is globally designed for striking a balance of overall exposures. The aesthetic evaluation function is approximated by discriminator in generative adversarial networks. The reinforcement learning and the adversarial learning are trained collaboratively by asynchronous deterministic policy gradient and generative loss approximation. To further simply the algorithmic architecture, we also prove the feasibility of leveraging the discriminator as the value function. Further more, we employ each local exposure to retouch the raw input image respectively, thus delivering multiple retouched images under different exposures which are fused with exposure blending. The extensive experiments verify that our algorithms are superior to state-of-the-art methods in terms of quantitative accuracy and visual illustration.

We identify a fundamental source of error in Q-learning and other forms of dynamic programming with function approximation. Delusional bias arises when the approximation architecture limits the class of expressible greedy policies. Since standard Q-updates make globally uncoordinated action choices with respect to the expressible policy class, inconsistent or even conflicting Q-value estimates can result, leading to pathological behaviour such as over/under-estimation, instability and even divergence. To solve this problem, we introduce a new notion of policy consistency and define a local backup process that ensures global consistency through the use of information sets---sets that record constraints on policies consistent with backed-up Q-values. We prove that both the model-based and model-free algorithms using this backup remove delusional bias, yielding the first known algorithms that guarantee optimal results under general conditions. These algorithms furthermore only require polynomially many information sets (from a potentially exponential support). Finally, we suggest other practical heuristics for value-iteration and Q-learning that attempt to reduce delusional bias.

Model-free reinforcement learning (RL) algorithms directly parameterize and update value functions or policies, bypassing the modeling of the environment. They are typically simpler, more flexible to use, and thus more prevalent in modern deep RL than model-based approaches. However, empirical work has suggested that they require large numbers of samples to learn. The theoretical question of whether not model-free algorithms are in fact \emph{sample efficient} is one of the most fundamental questions in RL. The problem is unsolved even in the basic scenario with finitely many states and actions. We prove that, in an episodic MDP setting, Q-learning with UCB exploration achieves regret $\tlO(\sqrt{H^3 SAT})$ where $S$ and $A$ are the numbers of states and actions, $H$ is the number of steps per episode, and $T$ is the total number of steps. Our regret matches the optimal regret up to a single $\sqrt{H}$ factor. Thus we establish the sample efficiency of a classical model-free approach. Moreover, to the best of our knowledge, this is the first model-free analysis to establish $\sqrt{T}$ regret \emph{without} requiring access to a ``simulator.''

Despite the success of single-agent reinforcement learning, multi-agent reinforcement learning (MARL) remains challenging due to complex interactions between agents. Motivated by decentralized applications such as sensor networks, swarm robotics, and power grids, we study policy evaluation in MARL, where agents with jointly observed state-action pairs and private local rewards collaborate to learn the value of a given policy. In this paper, we propose a double averaging scheme, where each agent iteratively performs averaging over both space and time to incorporate neighboring gradient information and local reward information, respectively. We prove that the proposed algorithm converges to the optimal solution at a global geometric rate. In particular, such an algorithm is built upon a primal-dual reformulation of the mean squared projected Bellman error minimization problem, which gives rise to a decentralized convex-concave saddle-point problem. To the best of our knowledge, the proposed double averaging primal-dual optimization algorithm is the first to achieve fast finite-time convergence on decentralized convex-concave saddle-point problems.

It is commonly believed that an agent making decisions on behalf of two or more principals who have different utility functions should adopt a Pareto optimal policy, i.e. a policy that cannot be improved upon for one principal without making sacrifices for another. Harsanyi's theorem shows that when the principals have a common prior on the outcome distributions of all policies, a Pareto optimal policy for the agent is one that maximizes a fixed, weighted linear combination of the principals' utilities. In this paper, we derive a more precise generalization for the sequential decision setting in the case of principals with different priors on the dynamics of the environment. We refer to this generalization as the Negotiable Reinforcement Learning (NRL) framework. In this more general case, the relative weight given to each principal's utility should evolve over time according to how well the agent's observations conform with that principal's prior. To gain insight into the dynamics of this new framework, we implement a simple NRL agent and empirically examine its behavior in a simple environment.