In this paper, we study the problem of estimator selection and hyper-parameter tuning in off-policy evaluation. Although cross-validation is the most popular method for model selection in supervised learning, off-policy evaluation relies mostly on theory-based approaches, which provide only limited guidance to practitioners. We show how to use cross-validation for off-policy evaluation. This challenges a popular belief that cross-validation in off-policy evaluation is not feasible. We evaluate our method empirically and show that it addresses a variety of use cases.

Artificial Intelligence (AI) repeatedly match or outperform radiologists in lab experiments. However, real-world implementations of radiological AI-based systems are found to provide little to no clinical value. This paper explores how to design AI for clinical usefulness in different contexts. We conducted 19 design sessions and design interventions with 13 radiologists from 7 clinical sites in Denmark and Kenya, based on three iterations of a functional AI-based prototype. Ten sociotechnical dependencies were identified as crucial for the design of AI in radiology. We conceptualised four technical dimensions that must be configured to the intended clinical context of use: AI functionality, AI medical focus, AI decision threshold, and AI Explainability. We present four design recommendations on how to address dependencies pertaining to the medical knowledge, clinic type, user expertise level, patient context, and user situation that condition the configuration of these technical dimensions.

Knowledge Graphs (KGs) are a major asset for companies thanks to their great flexibility in data representation and their numerous applications, e.g., vocabulary sharing, Q/A or recommendation systems. To build a KG it is a common practice to rely on automatic methods for extracting knowledge from various heterogeneous sources. But in a noisy and uncertain world, knowledge may not be reliable and conflicts between data sources may occur. Integrating unreliable data would directly impact the use of the KG, therefore such conflicts must be resolved. This could be done manually by selecting the best data to integrate. This first approach is highly accurate, but costly and time-consuming. That is why recent efforts focus on automatic approaches, which represents a challenging task since it requires handling the uncertainty of extracted knowledge throughout its integration into the KG. We survey state-of-the-art approaches in this direction and present constructions of both open and enterprise KGs and how their quality is maintained. We then describe different knowledge extraction methods, introducing additional uncertainty. We also discuss downstream tasks after knowledge acquisition, including KG completion using embedding models, knowledge alignment, and knowledge fusion in order to address the problem of knowledge uncertainty in KG construction. We conclude with a discussion on the remaining challenges and perspectives when constructing a KG taking into account uncertainty.

Detecting out-of-distribution (OOD) samples is important for deploying machine learning models in safety-critical applications such as autonomous driving and robot-assisted surgery. Existing research has mainly focused on unimodal scenarios on image data. However, real-world applications are inherently multimodal, which makes it essential to leverage information from multiple modalities to enhance the efficacy of OOD detection. To establish a foundation for more realistic Multimodal OOD Detection, we introduce the first-of-its-kind benchmark, MultiOOD, characterized by diverse dataset sizes and varying modality combinations. We first evaluate existing unimodal OOD detection algorithms on MultiOOD, observing that the mere inclusion of additional modalities yields substantial improvements. This underscores the importance of utilizing multiple modalities for OOD detection. Based on the observation of Modality Prediction Discrepancy between in-distribution (ID) and OOD data, and its strong correlation with OOD performance, we propose the Agree-to-Disagree (A2D) algorithm to encourage such discrepancy during training. Moreover, we introduce a novel outlier synthesis method, NP-Mix, which explores broader feature spaces by leveraging the information from nearest neighbor classes and complements A2D to strengthen OOD detection performance. Extensive experiments on MultiOOD demonstrate that training with A2D and NP-Mix improves existing OOD detection algorithms by a large margin. Our source code and MultiOOD benchmark are available at https://github.com/donghao51/MultiOOD.

Federated Learning (FL) is a distributed machine learning framework in which a set of local communities collaboratively learn a shared global model while retaining all training data locally within each community. Two notions of fairness have recently emerged as important issues for federated learning: group fairness and community fairness. Group fairness requires that a model's decisions do not favor any particular group based on a set of legally protected attributes such as race or gender. Community fairness requires that global models exhibit similar levels of performance (accuracy) across all collaborating communities. Both fairness concepts can coexist within an FL framework, but the existing literature has focused on either one concept or the other. This paper proposes and analyzes a post-processing fair federated learning (FFL) framework called post-FFL. Post-FFL uses a linear program to simultaneously enforce group and community fairness while maximizing the utility of the global model. Because Post-FFL is a post-processing approach, it can be used with existing FL training pipelines whose convergence properties are well understood. This paper uses post-FFL on real-world datasets to mimic how hospital networks, for example, use federated learning to deliver community health care. Theoretical results bound the accuracy lost when post-FFL enforces both notion of fairness. Experimental results illustrate that post-FFL simultaneously improves both group and community fairness in FL. Moreover, post-FFL outperforms the existing in-processing fair federated learning in terms of improving both notions of fairness, communication efficiency and computation cost.

The detection of cardiovascular diseases (CVD) using machine learning techniques represents a significant advancement in medical diagnostics, aiming to enhance early detection, accuracy, and efficiency. This study explores a comparative analysis of various machine learning algorithms, including Logistic Regression, Decision Tree, Random Forest, Gradient Boosting, Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and XGBoost. By utilising a structured workflow encompassing data collection, preprocessing, model selection and hyperparameter tuning, training, evaluation, and choice of the optimal model, this research addresses the critical need for improved diagnostic tools. The findings highlight the efficacy of ensemble methods and advanced algorithms in providing reliable predictions, thereby offering a comprehensive framework for CVD detection that can be readily implemented and adapted in clinical settings.

Fast feedforward networks (FFFs) are a class of neural networks that exploit the observation that different regions of the input space activate distinct subsets of neurons in wide networks. FFFs partition the input space into separate sections using a differentiable binary tree of neurons and during inference descend the binary tree in order to improve computational efficiency. Inspired by Mixture of Experts (MoE) research, we propose the incorporation of load balancing and Master Leaf techniques into the FFF architecture to improve performance and simplify the training process. We reproduce experiments found in literature and present results on FFF models enhanced using these techniques. The proposed architecture and training recipe achieves up to 16.3% and 3% absolute classification accuracy increase in training and test accuracy, respectively, compared to the original FFF architecture. Additionally, we observe a smaller variance in the results compared to those reported in prior research. These findings demonstrate the potential of integrating MoE-inspired techniques into FFFs for developing more accurate and efficient models.

WHO has declared that more than 2.2 billion people worldwide are suffering from visual disorders, such as media haze, glaucoma, and drusen. At least 1 billion of these cases could have been either prevented or successfully treated, yet they remain unaddressed due to poverty, a lack of specialists, inaccurate ocular fundus diagnoses by ophthalmologists, or the presence of a rare disease. To address this, the research has developed the Hybrid Trio-Network Model Algorithm for accurately diagnosing 12 distinct common and rare eye diseases. This algorithm utilized the RFMiD dataset of 3,200 fundus images and the Binary Relevance Method to detect diseases separately, ensuring expandability and avoiding incorrect correlations. Each detector, incorporating finely tuned hyperparameters to optimize performance, consisted of three feature components: A classical transfer learning CNN model, a two-stage CNN model, and a Siamese Network. The diagnosis was made using features extracted through this Trio-Model with Ensembled Machine Learning algorithms. The proposed model achieved an average accuracy of 97% and an AUC score of 0.96. Compared to past benchmark studies, an increase of over 10% in the F1-score was observed for most diseases. Furthermore, using the Siamese Network, the model successfully made predictions in diseases like optic disc pallor, which past studies failed to predict due to low confidence. This diagnostic tool presents a stable, adaptive, cost-effective, efficient, accessible, and fast solution for globalizing early detection of both common and rare diseases.

Machine Learning and AI have the potential to transform data-driven scientific discovery, enabling accurate predictions for several scientific phenomena. As many scientific questions are inherently causal, this paper looks at the causal inference task of treatment effect estimation, where we assume binary effects that are recorded as high-dimensional images in a Randomized Controlled Trial (RCT). Despite being the simplest possible setting and a perfect fit for deep learning, we theoretically find that many common choices in the literature may lead to biased estimates. To test the practical impact of these considerations, we recorded the first real-world benchmark for causal inference downstream tasks on high-dimensional observations as an RCT studying how garden ants (Lasius neglectus) respond to microparticles applied onto their colony members by hygienic grooming. Comparing 6 480 models fine-tuned from state-of-the-art visual backbones, we find that the sampling and modeling choices significantly affect the accuracy of the causal estimate, and that classification accuracy is not a proxy thereof. We further validated the analysis, repeating it on a synthetically generated visual data set controlling the causal model. Our results suggest that future benchmarks should carefully consider real downstream scientific questions, especially causal ones. Further, we highlight guidelines for representation learning methods to help answer causal questions in the sciences. All code and data will be released.

Selecting language models in business contexts requires a careful analysis of the final financial benefits of the investment. However, the emphasis of academia and industry analysis of LLM is solely on performance. This work introduces a framework to evaluate LLMs, focusing on the earnings and return on investment aspects that should be taken into account in business decision making. We use a decision-theoretic approach to compare the financial impact of different LLMs, considering variables such as the cost per token, the probability of success in the specific task, and the gain and losses associated with LLMs use. The study reveals how the superior accuracy of more expensive models can, under certain conditions, justify a greater investment through more significant earnings but not necessarily a larger RoI. This article provides a framework for companies looking to optimize their technology choices, ensuring that investment in cutting-edge technology aligns with strategic financial objectives. In addition, we discuss how changes in operational variables influence the economics of using LLMs, offering practical insights for enterprise settings, finding that the predicted gain and loss and the different probabilities of success and failure are the variables that most impact the sensitivity of the models.