Pathologists comprehensive evaluation of donor liver biopsies provides crucial information for accepting or discarding potential grafts. However, rapidly and accurately obtaining these assessments intraoperatively poses a significant challenge for pathologists. Features in donor liver biopsies, such as portal tract fibrosis, total steatosis, macrovesicular steatosis, and hepatocellular ballooning are correlated with transplant outcomes, yet quantifying these indicators suffers from substantial inter- and intra-observer variability. To address this, we introduce DLiPath, the first benchmark for comprehensive donor liver assessment based on a histopathology image dataset. We collected and publicly released 636 whole slide images from 304 donor liver patients at the Department of Pathology, the Third Xiangya Hospital, with expert annotations for key pathological features (including cholestasis, portal tract fibrosis, portal inflammation, total steatosis, macrovesicular steatosis, and hepatocellular ballooning). We selected nine state-of-the-art multiple-instance learning (MIL) models based on the DLiPath dataset as baselines for extensive comparative analysis. The experimental results demonstrate that several MIL models achieve high accuracy across donor liver assessment indicators on DLiPath, charting a clear course for future automated and intelligent donor liver assessment research. Data and code are available at https://github.com/panliangrui/ACM_MM_2025.

As financial institutions increasingly rely on machine learning models to automate lending decisions, concerns about algorithmic fairness have risen. This paper explores the tradeoff between enforcing fairness constraints (such as demographic parity or equal opportunity) and maximizing lender profitability. Through simulations on synthetic data that reflects real-world lending patterns, we quantify how different fairness interventions impact profit margins and default rates. Our results demonstrate that equal opportunity constraints typically impose lower profit costs than demographic parity, but surprisingly, removing protected attributes from the model (fairness through unawareness) outperforms explicit fairness interventions in both fairness and profitability metrics. We further identify the specific economic conditions under which fair lending becomes profitable and analyze the feature-specific drivers of unfairness. These findings offer practical guidance for designing lending algorithms that balance ethical considerations with business objectives.

Human learning and conceptual representation is grounded in sensorimotor experience, in contrast to state-of-the-art foundation models. In this paper, we investigate how well such large-scale models, trained on vast quantities of data, represent the semantic feature norms of concrete object concepts, e.g. a ROSE is red, smells sweet, and is a flower. More specifically, we use probing tasks to test which properties of objects these models are aware of. We evaluate image encoders trained on image data alone, as well as multimodally-trained image encoders and language-only models, on predicting an extended denser version of the classic McRae norms and the newer Binder dataset of attribute ratings. We find that multimodal image encoders slightly outperform language-only approaches, and that image-only encoders perform comparably to the language models, even on non-visual attributes that are classified as "encyclopedic" or "function". These results offer new insights into what can be learned from pure unimodal learning, and the complementarity of the modalities.

Legal decisions are increasingly evaluated for fairness, consistency, and bias using machine learning (ML) techniques. In high-stakes domains like refugee adjudication, such methods are often applied to detect disparities in outcomes. Yet it remains unclear whether statistical methods can meaningfully assess fairness in legal contexts shaped by discretion, normative complexity, and limited ground truth. In this paper, we empirically evaluate three common ML approaches (feature-based analysis, semantic clustering, and predictive modeling) on a large, real-world dataset of 59,000+ Canadian refugee decisions (AsyLex). Our experiments show that these methods produce divergent and sometimes contradictory signals, that predictive modeling often depends on contextual and procedural features rather than legal features, and that semantic clustering fails to capture substantive legal reasoning. We show limitations of statistical fairness evaluation, challenge the assumption that statistical regularity equates to fairness, and argue that current computational approaches fall short of evaluating fairness in legally discretionary domains. We argue that evaluating fairness in law requires methods grounded not only in data, but in legal reasoning and institutional context.

As hypothesis generation becomes increasingly automated, a new bottleneck has emerged: hypothesis assessment. Modern systems can surface thousands of statistical relationships-correlations, trends, causal links-but offer little guidance on which ones are novel, non-trivial, or worthy of expert attention. In this work, we study the complementary problem to hypothesis generation: automatic hypothesis assessment. Specifically, we ask: given a large set of statistical relationships, can we automatically assess which ones are novel and worth further exploration? We focus on correlations as they are a common entry point in exploratory data analysis that often serve as the basis for forming deeper scientific or causal hypotheses. To support automatic assessment, we propose to leverage the vast knowledge encoded in LLMs' weights to derive a prior distribution over the correlation value of a variable pair. If an LLM's prior expects the correlation value observed, then such correlation is not surprising, and vice versa. We propose the Logit-based Calibrated Prior, an LLM-elicited correlation prior that transforms the model's raw output logits into a calibrated, continuous predictive distribution over correlation values. We evaluate the prior on a benchmark of 2,096 real-world variable pairs and it achieves a sign accuracy of 78.8%, a mean absolute error of 0.26, and 95% credible interval coverage of 89.2% in predicting Pearson correlation coefficient. It also outperforms a fine-tuned RoBERTa classifier in binary correlation prediction and achieves higher precision@K in hypothesis ranking. We further show that the prior generalizes to correlations not seen during LLM pretraining, reflecting context-sensitive reasoning rather than memorization.

Skin cancer is among the most prevalent and life-threatening diseases worldwide, with early detection being critical to patient outcomes. This work presents a hybrid machine and deep learning-based approach for classifying malignant and benign skin lesions using the SLICE-3D dataset from ISIC 2024, which comprises 401,059 cropped lesion images extracted from 3D Total Body Photography (TBP), emulating non-dermoscopic, smartphone-like conditions. Our method combines vision transformers (EVA02) and our designed convolutional ViT hybrid (EdgeNeXtSAC) to extract robust features, employing a segmentation-assisted classification pipeline to enhance lesion localization. Predictions from these models are fused with a gradient-boosted decision tree (GBDT) ensemble enriched by engineered features and patient-specific relational metrics. To address class imbalance and improve generalization, we augment malignant cases with Stable Diffusion-generated synthetic lesions and apply a diagnosis-informed relabeling strategy to harmonize external datasets into a 3-class format. Using partial AUC (pAUC) above 80 percent true positive rate (TPR) as the evaluation metric, our approach achieves a pAUC of 0.1755 -- the highest among all configurations. These results underscore the potential of hybrid, interpretable AI systems for skin cancer triage in telemedicine and resource-constrained settings.

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns.

Violent threats remain a significant problem across social media platforms. Useful, high-quality data facilitates research into the understanding and detection of malicious content, including violence. In this paper, we introduce a cross-platform dataset of 30,000 posts hand-coded for violent threats and sub-types of violence, including political and sexual violence. To evaluate the signal present in this dataset, we perform a machine learning analysis with an existing dataset of violent comments from YouTube. We find that, despite originating from different platforms and using different coding criteria, we achieve high classification accuracy both by training on one dataset and testing on the other, and in a merged dataset condition. These results have implications for content-classification strategies and for understanding violent content across social media.

Postoperative stroke remains a critical complication in elderly surgical intensive care unit (SICU) patients, contributing to prolonged hospitalization, elevated healthcare costs, and increased mortality. Accurate early risk stratification is essential to enable timely intervention and improve clinical outcomes. We constructed a combined cohort of 19,085 elderly SICU admissions from the MIMIC-III and MIMIC-IV databases and developed an interpretable machine learning (ML) framework to predict in-hospital stroke using clinical data from the first 24 hours of Intensive Care Unit (ICU) stay. The preprocessing pipeline included removal of high-missingness features, iterative Singular Value Decomposition (SVD) imputation, z-score normalization, one-hot encoding, and class imbalance correction via the Adaptive Synthetic Sampling (ADASYN) algorithm. A two-stage feature selection process-combining Recursive Feature Elimination with Cross-Validation (RFECV) and SHapley Additive exPlanations (SHAP)-reduced the initial 80 variables to 20 clinically informative predictors. Among eight ML models evaluated, CatBoost achieved the best performance with an AUROC of 0.8868 (95% CI: 0.8802--0.8937). SHAP analysis and ablation studies identified prior cerebrovascular disease, serum creatinine, and systolic blood pressure as the most influential risk factors. Our results highlight the potential of interpretable ML approaches to support early detection of postoperative stroke and inform decision-making in perioperative critical care.

Multimodal large language models (MLLMs) demonstrate remarkable capabilities in handling complex multimodal tasks and are increasingly adopted in video understanding applications. However, their rapid advancement raises serious data privacy concerns, particularly given the potential inclusion of sensitive video content, such as personal recordings and surveillance footage, in their training datasets. Determining improperly used videos during training remains a critical and unresolved challenge. Despite considerable progress on membership inference attacks (MIAs) for text and image data in MLLMs, existing methods fail to generalize effectively to the video domain. These methods suffer from poor scalability as more frames are sampled and generally achieve negligible true positive rates at low false positive rates (TPR@Low FPR), mainly due to their failure to capture the inherent temporal variations of video frames and to account for model behavior differences as the number of frames varies. To address these challenges, we introduce Vid-SME, the first membership inference method tailored for video data used in video understanding LLMs (VULLMs). Vid-SME leverages the confidence of model output and integrates adaptive parameterization to compute Sharma-Mittal entropy (SME) for video inputs. By leveraging the SME difference between natural and temporally-reversed video frames, Vid-SME derives robust membership scores to determine whether a given video is part of the model's training set. Experiments on various self-trained and open-sourced VULLMs demonstrate the strong effectiveness of Vid-SME.