Multilabel data should be analysed for label dependence before applying multilabel models. Independence between multilabel data labels cannot be measured directly from the label values due to their dependence on the set of covariates $\vec{x}$, but can be measured by examining the conditional label covariance using a multivariate Probit model. Unfortunately, the multivariate Probit model provides an estimate of its copula covariance, and so might not be reliable in estimating constant covariance and dependent covariance. In this article, we compare three models (Multivariate Probit, Multivariate Bernoulli and Staged Logit) for estimating the constant and dependent multilabel conditional label covariance. We provide an experiment that allows us to observe each model's measurement of conditional covariance. We found that all models measure constant and dependent covariance equally well, depending on the strength of the covariance, but the models all falsely detect that dependent covariance is present for data where constant covariance is present. Of the three models, the Multivariate Probit model had the lowest error rate.

Approximate machine unlearning aims to remove the effect of specific data from trained models to ensure individuals' privacy. Existing methods focus on the removed records and assume the retained ones are unaffected. However, recent studies on the \emph{privacy onion effect} indicate this assumption might be incorrect. Especially when the model is differentially private, no study has explored whether the retained ones still meet the differential privacy (DP) criterion under existing machine unlearning methods. This paper takes a holistic approach to auditing both unlearned and retained samples' privacy risks after applying approximate unlearning algorithms. We propose the privacy criteria for unlearned and retained samples, respectively, based on the perspectives of DP and membership inference attacks (MIAs). To make the auditing process more practical, we also develop an efficient MIA, A-LiRA, utilizing data augmentation to reduce the cost of shadow model training. Our experimental findings indicate that existing approximate machine unlearning algorithms may inadvertently compromise the privacy of retained samples for differentially private models, and we need differentially private unlearning algorithms. For reproducibility, we have pubished our code: https://anonymous.4open.science/r/Auditing-machine-unlearning-CB10/README.md

Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, yet patient responses remain highly variable, and the biological mechanisms underlying resistance are poorly understood. While machine learning models hold promise for predicting responses to ICIs, most existing methods lack interpretability and do not effectively leverage the biological structure inherent to multi-omics data. Here, we introduce the Biologically Disentangled Variational Autoencoder (BDVAE), a deep generative model that integrates transcriptomic and genomic data through modality- and pathway-specific encoders. Unlike existing rigid, pathway-informed models, BDVAE employs a modular encoder architecture combined with variational inference to learn biologically meaningful latent features associated with immune, genomic, and metabolic processes. Applied to a pan-cancer cohort of 366 patients across four cancer types treated with ICIs, BDVAE accurately predicts treatment response (AUC-ROC = 0.94 on unseen test data) and uncovers critical resistance mechanisms, including immune suppression, metabolic shifts, and neuronal signaling. Importantly, BDVAE reveals that resistance spans a continuous biological spectrum rather than strictly binary states, reflecting gradations of tumor dysfunction. Several latent features correlate with survival outcomes and known clinical subtypes, demonstrating BDVAE's capability to generate interpretable, clinically relevant insights. These findings underscore the value of biologically structured machine learning in elucidating complex resistance patterns and guiding precision immunotherapy strategies.

Mixture-of-Experts (MoE) models have become increasingly powerful in multimodal learning by enabling modular specialization across modalities. However, their effectiveness remains unclear when additional modalities introduce more noise than complementary information. Existing approaches, such as the Partial Information Decomposition, struggle to scale beyond two modalities and lack the resolution needed for instance-level control. We propose Beyond Two-modality Weighting (BTW), a bi-level, non-parametric weighting framework that combines instance-level Kullback-Leibler (KL) divergence and modality-level mutual information (MI) to dynamically adjust modality importance during training. Our method does not require additional parameters and can be applied to an arbitrary number of modalities. Specifically, BTW computes per-example KL weights by measuring the divergence between each unimodal and the current multimodal prediction, and modality-wide MI weights by estimating global alignment between unimodal and multimodal outputs. Extensive experiments on sentiment regression and clinical classification demonstrate that our method significantly improves regression performance and multiclass classification accuracy.

The secondary use of healthcare data is vital for research and clinical innovation, but it raises concerns about patient privacy. This study investigates how to balance privacy preservation and data utility in healthcare data sharing, considering the perspectives of both data providers and data users. Using a dataset of adult patients hospitalized between 2013 and 2015, we predict whether sepsis was present at admission or developed during the hospital stay. We identify sub-populations, such as older adults, frequently hospitalized patients, and racial minorities, that are especially vulnerable to privacy attacks due to their unique combinations of demographic and healthcare utilization attributes. These groups are also critical for machine learning (ML) model performance. We evaluate three anonymization methods-$k$-anonymity, the technique by Zheng et al., and the MO-OBAM model-based on their ability to reduce re-identification risk while maintaining ML utility. Results show that $k$-anonymity offers limited protection. The methods of Zheng et al. and MO-OBAM provide stronger privacy safeguards, with MO-OBAM yielding the best utility outcomes: only a 2% change in precision and recall compared to the original dataset. This work provides actionable insights for healthcare organizations on how to share data responsibly. It highlights the need for anonymization methods that protect vulnerable populations without sacrificing the performance of data-driven models.

The pervasiveness of large language models (LLMs) in enterprise settings has also brought forth a significant amount of risks associated with their usage. Guardrails technologies aim to mitigate this risk by filtering LLMs' input/output text through various detectors. However, developing and maintaining robust detectors faces many challenges, one of which is the difficulty in acquiring production-quality labeled data on real LLM outputs prior to deployment. In this work, we propose backprompting, a simple yet intuitive solution to generate production-like labeled data for health advice guardrails development. Furthermore, we pair our backprompting method with a sparse human-in-the-loop clustering technique to label the generated data. Our aim is to construct a parallel corpus roughly representative of the original dataset yet resembling real LLM output. We then infuse existing datasets with our synthetic examples to produce robust training data for our detector. We test our technique in one of the most difficult and nuanced guardrails: the identification of health advice in LLM output, and demonstrate improvement versus other solutions. Our detector is able to outperform GPT-4o by up to 3.73%, despite having 400x less parameters.

Digital healthcare systems have enabled the collection of mass healthcare data in electronic healthcare records (EHRs), allowing artificial intelligence solutions for various healthcare prediction tasks. However, existing studies often focus on isolated components of EHR data, limiting their predictive performance and interpretability. To address this gap, we propose ProtoEHR, an interpretable hierarchical prototype learning framework that fully exploits the rich, multi-level structure of EHR data to enhance healthcare predictions. More specifically, ProtoEHR models relationships within and across three hierarchical levels of EHRs: medical codes, hospital visits, and patients. We first leverage large language models to extract semantic relationships among medical codes and construct a medical knowledge graph as the knowledge source. Building on this, we design a hierarchical representation learning framework that captures contextualized representations across three levels, while incorporating prototype information within each level to capture intrinsic similarities and improve generalization. To perform a comprehensive assessment, we evaluate ProtoEHR in two public datasets on five clinically significant tasks, including prediction of mortality, prediction of readmission, prediction of length of stay, drug recommendation, and prediction of phenotype. The results demonstrate the ability of ProtoEHR to make accurate, robust, and interpretable predictions compared to baselines in the literature. Furthermore, ProtoEHR offers interpretable insights on code, visit, and patient levels to aid in healthcare prediction.

The detection of brain tumor in MRI is an important aspect of ensuring timely diagnostics and treatment; however, manual analysis is commonly long and error-prone. Current approaches are not universal because they have limited generalization to heterogeneous tumors, are computationally inefficient, are not interpretable, and lack transparency, thus limiting trustworthiness. To overcome these issues, we introduce MobileDenseAttn, a fusion model of dual streams of MobileNetV2 and DenseNet201 that can help gradually improve the feature representation scale, computing efficiency, and visual explanations via GradCAM. Our model uses feature level fusion and is trained on an augmented dataset of 6,020 MRI scans representing glioma, meningioma, pituitary tumors, and normal samples. Measured under strict 5-fold cross-validation protocols, MobileDenseAttn provides a training accuracy of 99.75%, a testing accuracy of 98.35%, and a stable F1 score of 0.9835 (95% CI: 0.9743 to 0.9920). The extensive validation shows the stability of the model, and the comparative analysis proves that it is a great advancement over the baseline models (VGG19, DenseNet201, MobileNetV2) with a +3.67% accuracy increase and a 39.3% decrease in training time compared to VGG19. The GradCAM heatmaps clearly show tumor-affected areas, offering clinically significant localization and improving interpretability. These findings position MobileDenseAttn as an efficient, high performance, interpretable model with a high probability of becoming a clinically practical tool in identifying brain tumors in the real world.

Modern computer vision models have proven to be highly useful for medical imaging classification and segmentation tasks, but the scarcity of medical imaging data often limits the efficacy of models trained from scratch. Transfer learning has emerged as a pivotal solution to this, enabling the fine-tuning of high-performance models on small data. Mei et al. (2022) found that pre-training CNNs on a large dataset of radiologist-labeled images (RadImageNet) enhanced model performance on downstream tasks compared to ImageNet pretraining. The present work extends Mei et al. (2022) by conducting a comprehensive investigation to determine optimal CNN architectures for breast lesion malignancy detection and ACL tear detection, as well as performing statistical analysis to compare the effect of RadImageNet and ImageNet pre-training on downstream model performance. Our findings suggest that 1-dimensional convolutional classifiers with skip connections, ResNet50 pre-trained backbones, and partial backbone unfreezing yields optimal downstream medical classification performance. Our best models achieve AUCs of 0.9969 for ACL tear detection and 0.9641 for breast nodule malignancy detection, competitive with the results reported by Mei et al. (2022) and surpassing other previous works. We do not find evidence confirming RadImageNet pre-training to provide superior downstream performance for ACL tear and breast lesion classification tasks.

Currently available grammatical error correction (GEC) datasets are compiled using well-formed written text, limiting the applicability of these datasets to other domains such as informal writing and dialog. In this paper, we present a novel parallel GEC dataset drawn from open-domain chatbot conversations; this dataset is, to our knowledge, the first GEC dataset targeted to a conversational setting. To demonstrate the utility of the dataset, we use our annotated data to fine-tune a state-of-the-art GEC model, resulting in a 16 point increase in model precision. This is of particular importance in a GEC model, as model precision is considered more important than recall in GEC tasks since false positives could lead to serious confusion in language learners. We also present a detailed annotation scheme which ranks errors by perceived impact on comprehensibility, making our dataset both reproducible and extensible. Experimental results show the effectiveness of our data in improving GEC model performance in conversational scenario.