The exponential expansion of IoT and 5G-Advanced applications has enlarged the attack surface for DDoS, malware, and zero-day intrusions. We propose an intrusion detection system that fuses a convolutional neural network (CNN), a bidirectional LSTM (BiLSTM), and an autoencoder (AE) bottleneck within a privacy-preserving federated learning (FL) framework. The CNN-BiLSTM branch captures local and gated cross-feature interactions, while the AE emphasizes reconstruction-based anomaly sensitivity. Training occurs across edge devices without sharing raw data. On UNSW-NB15 (binary), the fused model attains AUC 99.59 percent and F1 97.36 percent; confusion-matrix analysis shows balanced error rates with high precision and recall. Average inference time is approximately 0.0476 ms per sample on our test hardware, which is well within the less than 10 ms URLLC budget, supporting edge deployment. We also discuss explainability, drift tolerance, and FL considerations for compliant, scalable 5G-Advanced IoT security.

In brain-computer interface (BCI) systems, steady-state visual evoked potentials (SSVEP) and P300 responses have achieved widespread implementation owing to their superior information transfer rates (ITR) and minimal training requirements. These neurophysiological signals have exhibited robust efficacy and versatility in external device control, demonstrating enhanced precision and scalability. However, conventional implementations predominantly utilise liquid crystal display (LCD)-based visual stimulation paradigms, which present limitations in practical deployment scenarios. This investigation presents the development and evaluation of a novel light-emitting diode (LED)-based dual stimulation apparatus designed to enhance SSVEP classification accuracy through the integration of both SSVEP and P300 paradigms. The system employs four distinct frequencies, 7 Hz, 8 Hz, 9 Hz, and 10 Hz, corresponding to forward, backward, right, and left directional controls, respectively. Oscilloscopic verification confirmed the precision of these stimulation frequencies. Real-time feature extraction was accomplished through the concurrent analysis of maximum Fast Fourier Transform (FFT) amplitude and P300 peak detection to ascertain user intent. Directional control was determined by the frequency exhibiting maximal amplitude characteristics. The visual stimulation hardware demonstrated minimal frequency deviation, with error differentials ranging from 0.15%to 0.20%across all frequencies. The implemented signal processing algorithm successfully discriminated all four stimulus frequencies whilst correlating them with their respective P300 event markers. Classification accuracy was evaluated based on correct task intention recognition. The proposed hybrid system achieved a mean classification accuracy of 86.25%, coupled with an average ITR of 42.08 bits per minute (bpm).

Large Language Model (LLMs) can be used to write or modify documents, presenting a challenge for understanding the intent behind their use. For example, benign uses may involve using LLM on a human-written document to improve its grammar or to translate it into another language. However, a document entirely produced by a LLM may be more likely to be used to spread misinformation than simple translation (\eg, from use by malicious actors or simply by hallucinating). Prior works in Machine Generated Text (MGT) detection mostly focus on simply identifying whether a document was human or machine written, ignoring these fine-grained uses. In this paper, we introduce a HiErarchical, length-RObust machine-influenced text detector (HERO), which learns to separate text samples of varying lengths from four primary types: human-written, machine-generated, machine-polished, and machine-translated. HERO accomplishes this by combining predictions from length-specialist models that have been trained with Subcategory Guidance. Specifically, for categories that are easily confused (\eg, different source languages), our Subcategory Guidance module encourages separation of the fine-grained categories, boosting performance. Extensive experiments across five LLMs and six domains demonstrate the benefits of our HERO, outperforming the state-of-the-art by 2.5-3 mAP on average.

Understanding the real-world effects of recreational drug use remains a critical challenge in public health and biomedical research, especially as traditional surveillance systems often underrepresent user experiences. In this study, we leverage social media (specifically Twitter) as a rich and unfiltered source of user-reported effects associated with three emerging psychoactive substances: ecstasy, GHB, and 2C-B. By combining a curated list of slang terms with biomedical concept extraction via MetaMap, we identified and weakly annotated over 92,000 tweets mentioning these substances. Each tweet was labeled with a polarity reflecting whether it reported a positive or negative effect, following an expert-guided heuristic process. We then performed descriptive and comparative analyses of the reported phenotypic outcomes across substances and trained multiple machine learning classifiers to predict polarity from tweet content, accounting for strong class imbalance using techniques such as cost-sensitive learning and synthetic oversampling. The top performance on the test set was obtained from eXtreme Gradient Boosting with cost-sensitive learning (F1 = 0.885, AUPRC = 0.934). Our findings reveal that Twitter enables the detection of substance-specific phenotypic effects, and that polarity classification models can support real-time pharmacovigilance and drug effect characterization with high accuracy.

Accurate prediction of drug-drug interactions (DDI) is crucial for medication safety and effective drug development. However, existing methods often struggle to capture structural information across different scales, from local functional groups to global molecular topology, and typically lack mechanisms to quantify prediction confidence. To address these limitations, we propose MPNP-DDI, a novel Multi-scale Graph Neural Process framework. The core of MPNP-DDI is a unique message-passing scheme that, by being iteratively applied, learns a hierarchy of graph representations at multiple scales. Crucially, a cross-drug co-attention mechanism then dynamically fuses these multi-scale representations to generate context-aware embeddings for interacting drug pairs, while an integrated neural process module provides principled uncertainty estimation. Extensive experiments demonstrate that MPNP-DDI significantly outperforms state-of-the-art baselines on benchmark datasets. By providing accurate, generalizable, and uncertainty-aware predictions built upon multi-scale structural features, MPNP-DDI represents a powerful computational tool for pharmacovigilance, polypharmacy risk assessment, and precision medicine.

We present a novel approach which extends the existing Fully Convolutional One-Stage Object Detector (FCOS) for mitotic figure detection. Our composite model adds a Feedback Attention Ladder CNN (FAL-CNN) model for classification of normal versus abnormal mitotic figures, feeding into a fusion network that is trained to generate adjustments to bounding boxes predicted by FCOS. Our network aims to reduce the false positive rate of the FCOS object detector, to improve the accuracy of object detection and enhance the generalisability of the network. Our model achieved an F1 score of 0.655 for mitosis detection on the preliminary evaluation dataset.

Background: There are many challenges and opportunities in the clinical deployment of AI tools in radiology. The current study describes a radiology software platform called NeoMedSys that can enable efficient deployment and refinements of AI models. We evaluated the feasibility and effectiveness of running NeoMedSys for three months in real-world clinical settings and focused on improvement performance of an in-house developed AI model (VIOLA-AI) designed for intracranial hemorrhage (ICH) detection. Methods: NeoMedSys integrates tools for deploying, testing, and optimizing AI models with a web-based medical image viewer, annotation system, and hospital-wide radiology information systems. A prospective pragmatic investigation was deployed using clinical cases of patients presenting to the largest Emergency Department in Norway (site-1) with suspected traumatic brain injury (TBI) or patients with suspected stroke (site-2). We assessed ICH classification performance as VIOLA-AI encountered new data and underwent pre-planned model retraining. Performance metrics included sensitivity, specificity, accuracy, and the area under the receiver operating characteristic curve (AUC). Results: NeoMedSys facilitated iterative improvements in the AI model, significantly enhancing its diagnostic accuracy. Automated bleed detection and segmentation were reviewed in near real-time to facilitate re-training VIOLA-AI. The iterative refinement process yielded a marked improvement in classification sensitivity, rising to 90.3% (from 79.2%), and specificity that reached 89.3% (from 80.7%). The bleed detection ROC analysis for the entire sample demonstrated a high area-under-the-curve (AUC) of 0.949 (from 0.873). Model refinement stages were associated with notable gains, highlighting the value of real-time radiologist feedback.

This paper proposes the Next-Depth Lookahead Tree (NDLT), a single-tree model designed to improve performance by evaluating node splits not only at the node being optimized but also by evaluating the quality of the next depth level. Conventional decision trees (DTs) rely on greedy node-by-node partitioning, which often fails to ensure global optimality of the tree and is prone to local optima when early splits are suboptimal. To overcome this limitation, NDLT employs a next-depth lookahead strategy that jointly considers the immediate impurity reduction at the parent node and the expected impurity reduction at its child nodes. Empirical evaluation on diverse and complex datasets, including high-dimensional and imbalanced cases, demonstrates that NDLT achieves performance comparable to or better than classical DTs and ensemble models such as Random Forests, XGBoost, and Light-GBM. These results show that NDLT preserves the interpretability of a single tree while delivering robust predictive accuracy, making it an effective approach for real-world applications where both transparency and performance are required. These authors contributed equally to this work. Introduction Decision Tree (DT) represents one of the earliest and most established algorithms in the field of machine learning, valued for its simplicity, inter-pretability, and broad applicability [1].

Empirical Risk Minimization (ERM) is a foundational framework for supervised learning but primarily optimizes average-case performance, often neglecting fairness and robustness considerations. Tilted Empirical Risk Minimization (TERM) extends ERM by introducing an exponential tilt hyperparameter $t$ to balance average-case accuracy with worst-case fairness and robustness. However, in online or streaming settings where data arrive one sample at a time, the classical TERM objective degenerates to standard ERM, losing tilt sensitivity. We address this limitation by proposing an online TERM formulation that removes the logarithm from the classical objective, preserving tilt effects without additional computational or memory overhead. This formulation enables a continuous trade-off controlled by $t$, smoothly interpolating between ERM ($t \to 0$), fairness emphasis ($t > 0$), and robustness to outliers ($t < 0$). We empirically validate online TERM on two representative streaming tasks: robust linear regression with adversarial outliers and minority-class detection in binary classification. Our results demonstrate that negative tilting effectively suppresses outlier influence, while positive tilting improves recall with minimal impact on precision, all at per-sample computational cost equivalent to ERM. Online TERM thus recovers the full robustness-fairness spectrum of classical TERM in an efficient single-sample learning regime.

Large Language Models (LLMs) have fundamentally transformed the field of natural language processing; however, their vulnerability to biases presents a notable obstacle that threatens both fairness and trust. This review offers an extensive analysis of the bias landscape in LLMs, tracing its roots and expressions across various NLP tasks. Biases are classified into implicit and explicit types, with particular attention given to their emergence from data sources, architectural designs, and contextual deployments. This study advances beyond theoretical analysis by implementing a simulation framework designed to evaluate bias mitigation strategies in practice. The framework integrates multiple approaches including data curation, debiasing during model training, and post-hoc output calibration and assesses their impact in controlled experimental settings. In summary, this work not only synthesizes existing knowledge on bias in LLMs but also contributes original empirical validation through simulation of mitigation strategies.